Browsing by Author "00594720-a627-45d3-903c-8f84fdf4e5c3"

Now showing items 1-3 of 3

    • On the role of DT- diaphorase inhibition in aminochrome- induced neurotoxicity in vivo 
      Herrera Soto, Andrea; Díaz Véliz, Gabriela; Mora Gutiérrez, Sergio; Muñoz, Patricia; Henny, Pablo; Steinbusch, Harry W. M.; Segura Aguilar, Juan (Springer, 2017)
      Dopamine oxidation in the pathway leading to neuromelanin formation generates the ortho-quinone aminochrome, which is potentially neurotoxic but normally rapidly converted by DT-diaphorase to nontoxic leukoaminochrome. ...
    • Reduced repressive epigenetic marks, increased DNA damage and Alzheimer's disease hallmarks in the brain ... 
      Calderón Garcidueñas, Lilian; Herrera Soto, Andrea; Jury, Nur; Maher, Bárbara; González Maciel, Angélica; Reynoso Robles, Rafael; Ruiz Rudolph, Pablo; van Zundert, Brigitte; Varela Nallar, Lorena (Elsevier, 2020)
      Exposure to air pollutants is associated with an increased risk of developing Alzheimer's disease (AD). AD pathological hallmarks and cognitive deficits are documented in children and young adults in polluted cities (e.g. ...
    • Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent ... 
      Jury, Nur; Abarzúa, Sebastián; Díaz, Iván; Guerra, Miguel V.; Ampuero, Estibaliz; Cubillos, Paula; Martínez, Pablo; Herrera Soto, Andrea; Arredondo, Cristian; Rojas, Fabiola; Manterola Zúñiga, Marcia; Rojas, Adriana; Montecino, Martín; Varela Nallar, Lorena; van Zundert, Brigitte (BMC, 2020)
      Background Hexanucleotide repeat expansions of the G(4)C(2) motif in a non-coding region of the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Tissues ...