Now showing items 1-14 of 14

    • Bone resorptive activity in symptomatic and asymptomatic apical lesions of endodontic origin 

      Salinas Muñoz, M.; Garrido Flores, Carlos; Baeza Paredes, Mauricio; Huaman Chipana, P.; García Sesnich, Jocelyn; Bologna, R.; Vernal Astudillo, Rolando; Hernández, M. (Springer, 2017)
      The aim of this study is to assess the levels and diagnostic accuracy of a set of bone resorption biomarkers, including TRAP-5, RANKL, and OPG in symptomatic and asymptomatic apical lesions and controls. Apical tissues ...
    • Clinical Effects of Lactobacillus rhamnosus in Non-Surgical Treatment of Chronic Periodontitis: A Randomized Placebo-Controlled Trial With 1-Year Follow-Up 

      Morales Chvtes, Alicia; Carvajal Pavez, Paola; Silva Steffens, Nora; Hernández Ríos, Emma; Godoy Villanueva, Claudia; Rodríguez Martínez, Gonzalo; Cabello Ibacache, Rodrigo; García Sesnich, Jocelyn; Hoare, Anilei; Díaz, Patricia I.; Gamonal Aravena, Jorge Antonio (American Academy of Periodontology, 2016-08)
      BACKGROUND: Probiotics are living microorganisms that provide beneficial effects for the host when administered in proper quantities. The aim of this double-masked placebo-controlled parallel-arm randomized clinical trial ...
    • Diagnostic accuracy for apical and chronic periodontitis biomarkers in gingival crevicular fluid: an exploratory study 

      Baeza Paredes, Mauricio; Garrido Flores, Carlos; Hernández Ríos, Patricia; Dezerega Piwonka, Andrea; García Sesnich, Jocelyn; Strauss Avendaño, Franz; Aitken Saavedra, Juan; Lesaffre, Emmanuel; Vanbelle, Sophie; Gamonal Aravena, Jorge Antonio; Brignardello Petersen, Romina; Tervahartiala, Taina; Sorsa, Timo; Hernández Ríos, Marcela (Wiley, 2016)
      AimThe aim of this study was to assess the levels and diagnostic accuracy of a set of potential biomarkers of periodontal tissue metabolism in gingival crevicular fluid (GCF) from patients with chronic periodontitis (CP) ...
    • High levels of CXC Ligand 12/stromal cell-derived factor 1 in apical lesions of endodontic origin associated with mast cell infiltration 

      Cavalla, Franco; Reyes, Montserrat; Vernal Astudillo, Rolando; Álvarez, Carla; Paredes, Rodolfo; García Sesnich, Jocelyn; Infante, Magdalena; Fariña, Valeska; Barrón, Ignacio; Hernández, Marcela (2013)
      Introduction CXC ligand 12/stromal-derived factor-1 (CXCL12/SDF-1) is a pleiotropic chemokine that regulates the influx of a wide range of leukocytes. The aim of this study was to characterize CXCL12/SDF-1 in apical lesions ...
    • High Levels of CXC Ligand 12/Stromal Cell–derived Factor 1 in Apical Lesions of Endodontic Origin Associated with Mast Cell Infiltration 

      Cavalla, Franco; Reyes Rojas, Montserrat de los Ángeles; Vernal Astudillo, Rolando; Álvarez, Carla; Paredes, Rodolfo; García Sesnich, Jocelyn; Infante, Magdalena; Fariña, Valeska; Barrón, Ignacio; Hernández Ríos, Marcela (American Association of Endodontists, 2013)
      Introduction: CXC ligand 12/stromal-derived factor-1 (CXCL12/SDF-1) is a pleiotropic chemokine that regulates the influx of a wide range of leukocytes. The aim of this study was to characterize CXCL12/SDF-1 in apical lesions ...
    • Host response mechanisms in periodontal diseases 

      Silva, Nora; Abusleme Ramos, Loreto Andrea; Bravo, Denisse; Dutzan Muñoz, Nicolás; García Sesnich, Jocelyn; Vernal Astudillo, Rolando; Hernández, Marcela; Gamonal Aravena, Jorge Antonio (Univ Sao Paulo Fac Odontologia Bauru, 2015)
      Periodontal diseases usually refer to common inflammatory disorders known as gingivitis and periodontitis, which are caused by a pathogenic microbiota in the subgingival biofilm, including Porphyromonas gingivalis, ...
    • Host-pathogen interactions in progressive chronic periodontitis 

      Hernández Ríos, Emma; Dutzan Muñoz, Nicolás; García Sesnich, Jocelyn; Abusleme Ramos, Loreto Andrea; Dezerega Piwonka, Andrea; Silva Steffens, Nora; González Bergas, Fermín; Vernal Astudillo, Rolando; Sorsa, T.; Gamonal Aravena, Jorge Antonio (Sage, 2011-10)
      Periodontitis is an infection characterized by the occurrence of supporting tissue destruction with an episodic nature. Disease progression is often determined by the loss of attachment level or alveolar bone, and sequential ...
    • Interleukin-21 expression and its association with proinflammatory cytokines in untreated chronic periodontitis patients 

      Dutzan, Nicolás; Vernal Astudillo, Rolando; Vaque, Jose; García Sesnich, Jocelyn; Hernandez, Marcela; Abusleme, Loreto; Dezerega, Andrea; Gutkind, J.; Gamonal Aravena, Jorge (2012)
      Background: Interleukin-21 (IL-21) controls the differentiation of T-helper Th17 cells and induces the production of IL-17 in this T-cell subtype. The aim of this study is to determine the relative expression of IL-21 ...
    • Levels of interleukin-21 in patients with untreated chronic periodontitis 

      Dutzan Muñoz, Nicolás; Rivas, Catalina; García Sesnich, Jocelyn; Henríquez, Leslie; Rivera Escobar, Oriana; Dezerega Piwonka, Andrea; Hernández Ríos, Emma; Silva Steffens, Nora; Aguillón Gutiérrez, Juan Carlos; Puente Piccardo, Javier; Vernal Astudillo, Rolando; Gamonal Aravena, Jorge Antonio (American Academy of Periodontology, 2011-10)
      BACKGROUND: A growing body of evidence suggested that interleukin (IL)-21 enhances the effector phase during T-cell responses. The aim of our study is to determine the levels of IL-21 in periodontal sites from patients ...
    • Matrix metalloproteinases regulate extracellular levels of SDF-1/CXCL12, IL-6 and VEGF in hydrogen peroxide-stimulated human periodontal ligament fibroblasts 

      Cavalla Ruiz, Ian; Osorio Alfaro, Constanza; Paredes, Rodolfo; Valenzuela Pedevila, María Antonieta; García Sesnich, Jocelyn; Sorsa, Timo; Tervahartiala, Taina; Hernández Ríos, Emma (Elsevier, 2015)
      Periodontitis is a highly prevalent infectious disease characterized by the progressive inflammatory destruction of tooth-supporting structures, leading to tooth loss. The underling molecular mechanisms of the disease ...
    • Microbiological and clinical effects of probiotics and antibiotics on nonsurgical treatment of chronic periodontitis: a randomized placebocontrolled trial with 9-month follow-up 

      Morales, Alicia; Gandolfo Peña, Alessandro Manuel; Bravo, Joel; Carvajal, Paola; Silva, Nora; Godoy, Claudia; García Sesnich, Jocelyn; Hoare, Anilei; Diaz, Patricia; Gamonal Aravena, Jorge Antonio (Universidad Sao Paulo Facultad Odontología Bauru, 2018)
      Objective: The aim of this double-blind, placebo-controlled and parallel-arm randomized clinical trial was to evaluate the effects of Lactobacillus rhamnosus SP1-containing probiotic sachet and azithromycin tablets as an ...
    • Presencia de Linfocitos T Reguladores en Periodontitis Crónica 

      Carré, L.; Franco Martínez, María Eugenia; Henríquez, L.; García Sesnich, Jocelyn; Dutzan Muñoz, Nicolás; Aguillón Gutiérrez, Juan Carlos; Gamonal Aravena, Jorge Antonio (Sociedad de Periodoncia de Chile., 2010-12)
      La enfermedad periodontal requiere de un hospedero susceptible para su desarrollo y progresión. Dentro de las características del hospedero se encuentra la respuesta T reguladora, que otorga tolerancia frente a antígenos ...
    • Pro-oxidant status and matrix metalloproteinases in apical lesions and gingival crevicular fluid as potential biomarkers for asymptomatic apical periodontitis and endodontic treatment response 

      Dezerega, Andrea; Madrid, Sonia; Mundi, Veránica; Valenzuela, María A.; Garrido, Mauricio; Paredes, Rodolfo; García Sesnich, Jocelyn; Ortega, Ana V.; Gamonal Aravena, Jorge Antonio; Hernández, Marcela (2012)
      Background: Oxidative stress and matrix metalloproteinases -9 and -2 are involved in periodontal breakdown, whereas gingival crevicular fluid has been reported to reflect apical status. The aim of this study was to ...
    • Rhythmic expression of functional MT1 melatonin receptors in the rat adrenal gland 

      Richter, Hans G.; Torres Farfán, Claudia; García Sesnich, Jocelyn; Abarzúa Catalán, Lorena; Henríquez Luna, Mauricio; Alvarez Felmer, Mauro; Gaete, Fernando; Rehren, Germán E.; Serón Ferré, María (ENDOCRINE SOC, 2008-03)
      We previously demonstrated that melatonin is involved in the regulation of adrenal glucocorticoid production in diurnal primates through activation of MT1 membrane-bound melatonin receptors. However, whether melatonin ...