Browsing by Author "0da9002a-f2b8-41db-b9bd-65e677ea71e2"

Now showing items 1-8 of 8

    • Antiproliferative and uncoupling effects of delocalized, lipophilic, cationic gallic acid derivatives on ... 
      Jara, José A.; Castro Castillo, Vicente; Saavedra-Olavarría, Jorge; Peredo, Liliana; Pavanni, Mario; Jaña, Fabián; Letelier, María Eugenia; Parra, Eduardo; Becker, María Inés; Morello Casté, Antonio; Kemmerling Weis, Ulrike; Maya Arango, Juan; Ferreira, Jorge (American Chemical Society, 2014)
      Tumor cells principally exhibit increased mitochondrial transmembrane potential (Δψm) and altered metabolic pathways. The therapeutic targeting and delivery of anticancer drugs to the mitochondria might improve treatment ...
    • Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum–to–mitochondria Ca2+ ... 
      Cárdenas, César; Lovy, Alenka; Silva Pavéz, Eduardo; Urra Faúndez, Félix; Mizzoni, Craig; Ahumada Castro, Ulises; Bustos, Galdo; Jaña, Fabián; Cruz, Pablo; Farías, Paula; Mendoza, Elizabeth; Huerta, Hernán; Murgas, Paola; Hunter, Martín; Ríos, Melany; Cerda Arancibia, Oscar; Georgakoudi, Irene; Zakarian, Armen; Molgó, Jordi; Foskett, James Kevin (AAAS. American Association for the Advancement of Science, 2020)
      Spontaneous Ca2+ signaling from the InsP(3)R intracellular Ca2+ release channel to mitochondria is essential for optimal oxidative phosphorylation (OXPHOS) and ATP production. In cells with defective OXPHOS, reductive ...
    • Idiopathic inflammatory myopathy human derived cells retain their ability to increase mitochondrial function 
      Basualto Alarcón, Carla; Urra, Félix; Bozán, María Francisca; Jaña, Fabián; Trangulao, Alejandra; Bevilacqua, Jorge A.; Cárdenas, J. César (Public Library Science, 2020)
      Idiopathic Inflammatory Myopathies (IIMs) have been studied within the framework of autoimmune diseases where skeletal muscle appears to have a passive role in the illness. However, persiting weakness even after resolving ...
    • Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the AktmTOR-NFkB-Opa-1 signaling pathway 
      Parra, Valentina; Verdejo, Hugo E.; Iglewski, Myriam; Del Campo, Andrea; Troncoso, Rodrigo; Jones, Deborah; Zhu, Yi; Kuzmicic Previtali, Jovan Paolo; Pennanen, Christian; López Crisosto, Camila; Jaña, Fabián; Ferreira, Jorge; Noguera, Eduard; Chiong Lay, Mario; Bernlohr, David A.; Klip, Amira (2014)
      Insulin regulates heart metabolism through the regulation of insulin-stimulated glucose uptake. Studies have indicated that insulin can also regulate mitochondrial function. Relevant to this idea, mitochondrial function ...
    • KCTD5, a novel TRPM4-regulatory protein required for cell migration as a new predictor for breast cancer prognosis 
      Rivas, José; Díaz, Nicolás; Silva, Ian; Morales, Dana; Lavanderos, Boris; Álvarez, Alhejandra; Saldías Maulén, María Paz; Pulgar Pulgar, Eduardo; Cruz Núñez, Pablo; Maureira, Diego; Flores Utreras, Guillermo; Colombo Flores, Alicia; Blanco, Constanza; Contreras Muñoz, Héctor; Jaña, Fabián; Gallegos Méndez, Iván; Concha Nordemann, Miguel; Vergara Jaque, Ariela; Poblete, Horacio; González, Wendy; Varela Lekanda, Diego; Trimmer, James; Cáceres Lluch, Mónica Andrea; Cerda Arancibia, Óscar (Wiley, 2020)
      Transient receptor potential melastatin 4 (TRPM4) is a Ca2+-activated nonselective cationic channel that regulates cell migration and contractility. Increased TRPM4 expression has been related to pathologies, in which ...
    • Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to ... 
      Carreras-Sureda, Amado; Jaña, Fabián; Urra, Hery; Durand, Sylvere; Mortenson, David E.; Sagredo, Alfredo; Bustos, Galdo; Hazari, Younis; Ramos-Fernández, Eva; Sassano, Maria L.; Pihán, Philippe; van Vliet, Alexander R.; González-Quiroz, Matías; Torres, Angie K.; Tapia- (Nature Publishing Group, 2019)
      Mitochondria-associated membranes (MAMs) are central microdomains that fine-tune bioenergetics by the local transfer of calcium from the endoplasmic reticulum to the mitochondrial matrix. Here, we report an unexpected ...
    • Prolonged Activation of the Htr2b Serotonin Receptor Impairs Glucose Stimulated Insulin Secretion and ... 
      Cataldo, Luis Rodrigo; Mizgier, María Luisa; Bravo Sagua, Roberto; Jaña, Fabián; Cárdenas, César; Llanos Vidal, Paola; Busso, Dolores; Olmos, Pablo; Galgani Fuentes, José; Santos, José Luis; Cortés, Víctor A. (Public Library of Science, 2017)
      © 2017 Cataldo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the ...
    • Publisher Correction: Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum ... 
      Carreras-Sureda, Amado; Jaña, Fabián; Urra, Hery; Durand, Sylvere; Mortenson, David E.; Sagredo, Alfredo; Bustos, Galdo; Hazari, Younis; Ramos-Fernández, Eva; Sassano, Maria L.; Pihán, Philippe; van Vliet, Alexander R.; González-Quiroz, Matías; Torres, Angie K.; Tapia- (Nature Publishing Group, 2019)
      An amendment to this paper has been published and can be accessed via a link at the top of the paper.