Browsing by Author "18ef171e-1ae3-404f-845c-10eea8c364e8"

Now showing items 1-9 of 9

    • Association analysis in a Latin American population revealed ethnic differences in rheumatoid arthritis-associated ... 
      Castro Santos, P.; Verdugo Salgado, Ricardo; Alonso-Arias, R.; Gutiérrez, M. A.; Suazo Sanhueza, José; Aguillón Gutiérrez, Juan; Olloquequi, J.; Pinochet, C.; Lucía, A.; Quiñones, L. A.; Díaz Peña, R. (Nature, 2020)
      Large genome-wide association studies (GWAS) have increased our knowledge of the genetic risk factors of rheumatoid arthritis (RA). However, little is known about genetic susceptibility in populations with a large admixture ...
    • chromPlot: visualization of genomic data in chromosomal context 
      Oróstica, Karen Y.; Verdugo Salgado, Ricardo (Oxford Univ Press, 2016)
      Visualizing genomic data in chromosomal context can help detecting errors in data processing and may suggest new hypotheses to be tested. Here, we report a new tool for displaying large and diverse genomic data along ...
    • Development of a small panel of SNPs to infer ancestry in chileans that distinguishes Aymara and Mapuche components 
      Verdugo Salgado, Ricardo; Di Genova, Alex; Herrera Cisterna, Luisa; Moraga Vergara, Mauricio; Acuña Patzke, Mónica; Berríos del Solar, María Soledad; Llop Romero, Elena; Valenzuela, Carlos Y.; Bustamante Calderón, María Leonor; Digman, Dayhana; Symon Maturana, Adriana; Asenjo, Soledad; López Contreras, Pamela; Blanco, Alejandro E.; Suazo Sanhueza, José; Barozet, Emmanuelle; Caba, Fresia; Villalón Calderón, Marcelo; Alvarado Orellana, Sergio; Cáceres Lillo, Dante; Salgado, Katherine; Portales, Pilar; Moreno Estrada, Andrés; Gignoux, Christopher; Sandoval, Karla; Bustamante, Carlos; Eng, Celeste; Huntsman, Scott; Burchard, Esteban; Loira, Nicolás; Maass Sepúlveda, Alejandro; Cifuentes Ovalle, Lucía (Sociedad de Biología de Chile, 2020)
      Background Current South American populations trace their origins mainly to three continental ancestries, i.e. European, Amerindian and African. Individual variation in relative proportions of each of these ancestries may ...
    • Dexamethasone and monophosphoryl lipid a induce a distinctive profile on monocyte-derived dendritic cells ... 
      García González, Paulina; Schinnerling, Katina; Sepúlveda Gutierrez, Alejandro; Maggi, Jaxaira; Mehdi, Ahmed M.; Nel, Hendrik J.; Pesce Reyes, Bárbara; Larrondo Lillo, Milton; Aravena, Octavio; Molina Sampayo, María Carmen; Catalán Martina, Diego; Thomas, Ranjeny; Verdugo Salgado, Ricardo; Aguillón Gutiérrez, Juan Carlos (Frontiers Media SA, 2017)
      There is growing interest in the use of tolerogenic dendritic cells (tolDCs) as a potential target for immunotherapy. However, the molecular bases that drive the differentiation of monocyte-derived DCs (moDCs) toward a ...
    • Dexamethasone and MPLA treatment of monocyte-derived dendritic cells from rheumatoid arthritis patients ... 
      García González, P. A.; Schinnerling, Katina; Sepúlveda A., Jocelyne; Ubilla Olguín, Gabriela; Soto, L.; Neira Quiroga, Oscar; Medhi, A. M.; Nel, H. J.; Catalán Martina, Diego; Thomas, R. C.; Verdugo Salgado, Ricardo; Aguillón Gutiérrez, Juan Carlos (2016)
    • HLA-DRB1*07:01 and*08:02 Alleles Confer a Protective Effect Against ACPA-Positive Rheumatoid Arthritis in ... 
      Castro Santos, Patricia; Olloquequi, Jordi; Verdugo Salgado, Ricardo; Gutiérrez, Miguel A.; Pinochet, Carmen; Quiñones Sepúlveda, Luis; Díaz Peña, Roberto (MDPI, 2020)
      The focus of the genetic studies on rheumatoid arthritis has been on Europeans or European-derived populations, with limited information available on other populations, especially in Latin America. The aim of the present ...
    • Native American gene flow into Polynesia predating Easter Island settlement 
      Ioannidis, Alexander G.; Blanco Portillo, Javier; Sandoval, Karla; Hagelberg, Erika; Miquel-Poblete, Juan Francisco; Moreno Mayar, J. Víctor; Rodríguez Rodríguez, Juan Esteban; Auckland, Kathryn; Parks, Tom; Robson, Kathryn; Hill, Adrian V. S.; Ávila Arcos, María C.; Sockell, Alexandra; Homburger, Julian R; Wojcik, Genevieve L.; Barnes, Kathleen C.; Herrera, Luisa M.; Berríos, Soledad; Acuña, Mónica; Llop, Elena; Eng, Celeste; Huntsman, Scott; Burchard, Esteban G.; Gignoux, Christopher R.; Cifuentes, Lucía O.; Verdugo Salgado, Ricardo; Moraga Vergara, Mauricio; Mentzer, Alexander J.; Bustamante, Carlos D.; Moreno Estrada, Andrés (Nature, 2020)
      The possibility of voyaging contact between prehistoric Polynesian and Native American populations has long intrigued researchers. Proponents have pointed to the existence of New World crops, such as the sweet potato and ...
    • Polymorphisms PSCA rs2294008, IL-4 rs2243250 and MUC1 rs4072037 are associated with gastric cancer in a ... 
      González Hormazábal, Patricio; Retamales Ortega, Rocío; Musleh Katan, Maher; Bustamante, Marco; Stambuk, Juan; Pisano, Raúl; Valladares Hernández, Héctor; Lanzarini Sobrevía, Enrique; Chiong Tello, Héctor; Suazo, José; Quiñones Sepúlveda, Luis; Varela Figueroa, Nelson; Castro, Gonzalo; Jara, Lilian; Verdugo Salgado, Ricardo; Berger, Zoltan (Springer, 2020)
      Genetic variants are considered risk factors for gastric cancer. To date, 61 polymorphisms have been identified as associated with this disease. The aim of the present study was to analyze the association of some of those ...
    • Treatment with dexamethasone and monophosphoryl lipid a removes disease-associated transcriptional signatures ... 
      García González, Paulina; Schinnerling, Katina; Sepúlveda Gutiérrez, Alejandro; Maggi, Jaxaira; Hoyos, Lorena; Morales, Rodrigo; Mehdi, Ahmed; Nel, Hendrik; Soto Sáez, Lilian; Pesce Reyes, Bárbara; Molina Sampayo, María Carmen; Cuchacovich Turteltaub, Miguel; Larrondo Lillo, Milton; Neira, Oscar; Catalán Martina, Diego; Hilkens, Catharien M.; Thomas, Ranjeny; Verdugo Salgado, Ricardo; Aguillón Gutiérrez, Juan Carlos (Frontiers Media, 2016-10-25)
      Tolerogenic dendritic cells (TolDCs) are promising tools for therapy of autoimmune diseases, such as rheumatoid arthritis (RA). Here, we characterize monocyte-derived TolDCs from RA patients modulated with dexamethasone ...