Browsing by Author "1b923a20-fd19-4ea1-b5e8-2b3504b08cb9"

Now showing items 1-7 of 7

    • Biophysical and evolutionary aspects of domain swapping in the forkhead domain of human FoxP protein 
      Medina González, Exequiel; Reyes, Javiera; Villalobos, Pablo; Komives, Elizabeth A.; Babul Cattán, Jorge; Ramírez Sarmiento, César A. (Cell Press, 2017-02-03)
    • Cold adapted ADP-dependent sugar kinase: biophysical and evolutionary study of its flexibility 
      Guixé Leguía, Victoria Cristina; Zamorano Sarria, Ricardo; Ramírez Sarmiento, César A.; Castro Fernández, Víctor; Cayul Villalobos, Pablo; Komives, Elizabeth (Wiley, 2017)
    • Intrinsically Disordered Regions of the DNABinding Domain of Human FoxP1 Facilitate Domain Swapping 
      Medina, Exequiel; Torres Villalobos, Pablo; Hamilton, George L.; Komives, Elizabeth A.; Sanabria, Hugo; Ramírez Sarmiento, César A.; Babul, Jorge (Elsevier, 2020)
      Forkhead box P (FoxP) proteins are unique transcription factors that spatiotemporally regulate gene expression by tethering two chromosome loci together via functional domain-swapped dimers formed through their ...
    • Model of the Ankyrin and SOCS Box Protein, ASB9, E3 Ligase Reveals a Mechanism for Dynamic Ubiquitin Transfer 
      Schiffer, Jamie M.; Malmstrom, Robert D.; Parnell, Jonathan; Ramírez Sarmiento, César; Reyes, Javiera; Amaro, Rommie E.; Komives, Elizabeth A. (2016)
      Cullin-RING E3 ligases (CRLs) are elongated and bowed protein complexes that transfer ubiquitin over 60 angstrom to proteins targeted for proteasome degradation. One such CRL contains the ankyrin repeat and SOCS box protein ...
    • PKD2/polycystin-2 induces autophagy by forming a complex with BECN1 
      Peña Oyarzún, Daniel; Rodríguez Peña, Marcelo; Burgos Bravo, Francesca; Vergara, Ángelo; Kretschmar Montecinos, Catalina; Sotomayor Flores, Cristián; Ramírez Sarmiento, César A.; De Smedt, Humbert; Reyes Rojas, Montserrat; Pérez, William; Torres Gómez, Vicente; Morselli, Eugenia; Altamirano, Francisco; Wilson, Christian; Hill, Joseph A.; Lavandero González, Sergio; Criollo Céspedes, Alfredo (Taylor & Francis, 2020)
      Macroautophagy/autophagy is an intracellular process involved in the breakdown of macromolecules and organelles. Recent studies have shown that PKD2/PC2/TRPP2 (polycystin 2, transient receptor potential cation channel), a ...
    • Tuning of conformational dynamics through evolution-based design modulates the catalytic adaptability of ... 
      Zamora, Ricardo A.; Ramírez Sarmiento, César; Castro Fernández, Víctor; Villalobos, Pablo; Maturana, Pablo; Herrera Morandé, Alejandra; Komives, Elizabeth A.; Guixe, Victoria (American Chemical Society, 2020)
      Conformational flexibility plays a critical role in enzyme function and is a key aspect in transitions from an open to a closed state induced by substrate binding and product release. Psychrophilic enzymes display a high ...
    • Unusual dimerization of a BcCsp mutant leads to reduced conformational dynamics 
      Carvajal, Alonso I.; Vallejos, Gabriel; Komives, Elizabeth A.; Castro Fernández, Víctor; Leonardo, Diego A.; Garratt, Richard C.; Ramírez Sarmiento, César A.; Babul Cattán, Jorge (Wiley, 2017)
      Cold shock proteins (Csp) constitute a family of ubiquitous small proteins that act as RNA-chaperones to avoid cold-induced termination of translation. All members contain two subdomains composed of 2 and 3 beta-strands, ...