• 1,2,4-Triazine N-oxide derivatives: Studies as potential hypoxic cytotoxins. Part III 

      Cerecetto, Hugo; González, M.; Risso, Mariela; Saenza, P.; Olea Azar, Claudio; Bruno, A. M.; Azqueta, Amaia; De Cerain, A. L.; Monge, A. (WILEY-V C H VERLAG GMBH, 2004-05)
      New 5-(2-arylethenyl)-1,2,4-triazine N-oxide and N,N'-dioxide derivatives were synthesized in order to obtain compounds as selective hypoxic cell cytotoxins. The desired products were obtained when the 5-methyl heterocycle ...
    • A Computationally Efficient and Reliable Bond Order Measure 

      Mera, Raúl; Mendizábal Emaldía, Fernando; Olea Azar, Claudio; Miranda Rojas, Sebastián; Fuentealba Rosas, Patricio (AMER CHEMICAL SOC, 2011-05-05)
      Bond order indexes are useful measures that connect quantum mechanical results with chemical understanding. One of these measures, the natural bond order index, based on the natural resonance theory procedure and part of ...
    • Anti-trypanosomatid benzofuroxans and deoxygenated analogues: Synthesis using polymer-supported triphenylphosphine, biological evaluation and mechanism of action studies 

      Castro, Diego; Boiani, Lucía; Benítez, Diego; Hernández, Paola; Merlino, Alicia; Gil, Carmen; Olea Azar, Claudio; González, Mercedes; Cerecetto, Hugo; Porcal, Williams (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2009-12)
      Hybrid vinylthio-, vinylsulfinyl-, vinylsulfonyl- and vinylketo-benzofuroxans developed as anti-trypanosomatid agents, against Trypanosoma cruzi and Leishmania spp., have showed low micromolar IC50 values. The synthetic ...
    • Antioxidant activity of the mangiferin inclusion complex with beta-cyclodextrin 

      Rocha Ferreira, Fabricia da; Barros Valentim, Iara; Catarí Ramones, Edgar Luís; Salles Trevisan, Maria Teresa; Pérez Cruz, Fernanda; Olea Azar, Claudio; Caxico de Abreu, Fabiane; Fonseca Goulart, Marília Oliveira (Elsevier, 2012-09-28)
      The aim of this study was to characterize the complex between mangiferin (MGN) with beta-cyclodextrin (beta-CD) obtained through the co-evaporation method using Differential Scanning Calorimetry (DSC) and Fourier Transform ...
    • Antioxidant properties and free radical-scavenging reactivity of a family of hydroxynaphthalenones and dihydroxyanthracenones 

      Olea Azar, Claudio; Cavieres, C.; Norambuena, Ester; Delgado Castro, Tomás; Soto Labbé, Jorge; Rodríguez Borges, Jorge; Araya Maturana, Ramiro (PERGAMON-ELSEVIER SCIENCE LTD, 2007-11-15)
      This study was undertaken to investigate the free radical -scavenging and antioxidant activities of various structurally related hydroquinones including hydroxynaplithalenones and dihydroxyanthracenones. Electron spin ...
    • Apoptosis induced by hyperosmotic stress 

      Eisner, Verónica; Quiroga Lagos, Clara; Criollo Céspedes, Alfredo; Olea Azar, Claudio; Díaz Araya, G.; Chiong Lay, Mario; Lavandero González, Sergio (PERGAMON-ELSEVIER SCIENCE LTD, 2004)
      Meeting Abstract
    • Applications of electron spin, resonance and spin trapping in tropical parasitic diseases 

      Olea Azar, Claudio; Rigol Olsen, Carolina; Mendizábal Emaldía, Fernando; Briones, Rodolfo (BENTHAM SCIENCE PUBL LTD, 2006-02)
      Free radicals may be reaction intermediates in biological systems in more situations than are presently recognized. However, progress in detecting such species by Electron Spin Resonance (ESR) has been relatively slow. ESR ...
    • Ceramide-induced formation of ROS and ATP depletion trigger necrosis in lymphoid cells 

      Villena, Joan; Henríquez Luna, Mauricio; Torres Gómez, Vicente; Moraga, Francisco; Díaz Elizondo, Jessica Alejandra; Arredondo, Cristian; Chiong Lay, Mario; Olea Azar, Claudio; Stutzin Schottlander, Andrés; Lavandero González, Sergio; Quest, Andrew F. G. (ELSEVIER SCIENCE INC, 2008-03-15)
      In lymphocytes, Fas activation leads to both apoptosis and necrosis, whereby the latter form of cell death is linked to delayed production of endogenous ceramide and is mimicked by exogenous administration of long- and ...
    • Characterization, phase-solubility, and molecular modeling of inclusion complex of 5-nitroindazole derivative with cyclodextrins 

      Jullian Matthaei, Carolina; Morales Montecinos, Javier; Zapata Torres, Gerald Amilcar; Aguilera, Benjamín; Rodríguez Borges, Jorge; Arán, Vicente J.; Olea Azar, Claudio (PERGAMON-ELSEVIER SCIENCE LTD, 2008-05-01)
      The slightly water-soluble 5-nitroindazole derivative (5-NI) and its inclusion with either beta-cyclodextrin (beta CD) or Heptakis (2,6-di-O-methyl)-beta- cyclodextrin (DM beta CD) were investigated. The stoichiometric ...
    • Comparative evaluation of the acceptor properties of quinone derivatized polypyridinic ligands 

      Norambuena V., Ester; Olea Azar, Claudio; Delgadillo, Alvaro; Barrera, Mauricio; Loeb, Bárbara (ELSEVIER SCIENCE BV, 2009-05-18)
      The reduction properties of four acceptor polipyridyl ligands modified with quinones were studied by different experimental methods, as cyclic voltammetry and ESR spectroscopy, and by theoretical calculations. ESR spectra ...
    • Comparative SCF MO studies for some histamine analogues as agonists of the H2 receptor of histamine 

      Olea Azar, Claudio; Parra Mouchet, Julia (Sociedad Chilena de Química, 1999)
      This paper presents SCF AM1 and CNDO/2 RF calculations of the potential energy surface of histamine monocation (HA) and the agonists 2-(4-thiazolyl)ethylamine (TIA) and 2-(4-oxazolyl)ethylamine (OXA). the similarity of ...
    • Comparative spectroscopic and electrochemical study of nitroindazoles: 3-Alcoxy, 3-hydroxy and 3-oxo derivatives 

      Olea Azar, Claudio; Barriga, Germán; Folch, Christian; Gerpe, Alejandra; Cerecetto, Hugo; González, Mercedes; Rodríguez Borges, Jorge (PERGAMON-ELSEVIER SCIENCE LTD, 2008-08)
      Cyclic voltammetry and electron spin resonance techniques were used in the investigation of novel 3-alkoxy- and 3-hydroxy-1-[omega-(dialkylamino)alkyl]-5-nitroindazole derivatives. A self-protonation process involving the ...
    • Complexation of morin with three kinds of cyclodextrin - A thermodynamic and reactivity study 

      Jullian Matthaei, Carolina; Orosteguis, Teresita; Pérez Cruz, Fernanda; Sánchez, Paulina; Mendizábal Emaldía, Fernando; Olea Azar, Claudio (PERGAMON-ELSEVIER SCIENCE LTD, 2008-11-01)
      Properties of inclusion complexes between morin (M) and beta-cyclodextrin (beta CD), 2-hydroxypropyl-beta-cyclodextrin (HP beta CD) and Heptakis (2,6-O-di methyl) beta-cycloclextrin (DM beta CD) such as aqueous solubility ...
    • Complexation of quercetin with three kinds of cyclodextrins: An antioxidant study 

      Jullian Matthaei, Carolina; Moyano, L.; Yáñez Soto, Claudia; Olea Azar, Claudio (PERGAMON-ELSEVIER SCIENCE LTD, 2007-05)
      The slightly water-soluble flavonoid quercetin (QUE) and its inclusion with either beta-cyclodextrin (beta CD), hydroxypropyl-beta-cyclodextrin (HP-beta CD) or sulfobutyl ether-beta-cyclodextrin (SBE-beta CD) were investigated. ...
    • Complexes self-associate by hydrogen bonding and metallophilic attraction: Theoretical study 

      Mendizábal Emaldía, Fernando; Reyes, Dana; Olea Azar, Claudio (JOHN WILEY, 2006-03-15)
      Hydrogen bonding and metallophilic attractions are studied in the model systems: [(AuNH3Cl)(2)], [(AuNH(CH3)(2)Cl)(2)], [{Au-2(mu-SH)(PH2O)(PH2OH}(2)], [(CuNH3Cl)(2)], and [{Cu(NH3)Cl}(4)] at the Hartree-Fock (HF) and ...
    • Computer assisted design of potentially active anti-trypanosomal compounds 

      Paulino, M.; Iribarne, F.; Hansz, M.; Vega, M.; Seoane, G.; Cerecetto, Hugo; Di Maio, R.; Caracelli, I.; Zukerman-Schpector, J.; Olea Azar, Claudio; Stoppani, A. O. M.; Berriman, M.; Fairlamb, A. H.; Tapia, O. (ELSEVIER SCIENCE BV, 2002-04-26)
      A computer assisted molecular modeling was used to design molecules having a shape complementary to the active site of glutathione reductase (GR) and trypanothione reductase (TR). The designed 5-nitro compound derivatives. ...
    • Contribution of metals, sulfur-dioxide and phenolic compounds to the antioxidant capacity of Carménère wines 

      Zúñiga, María A.; Pérez Roa, Rodolfo E.; Olea Azar, Claudio; Laurie, V. Felipe; Agosin Trumper, Eduardo (Elsevier, 2014)
      In this research, we determined the chemical composition of 37 Vitis vinifera cv. Carme´ne` re wines and established their antioxidant capacity (AC). A set of 26 measurements of chemical species potentially related to ...
    • Copper neurotoxicity is dependent on dopamine-mediated copper uptake and one-electron reduction of aminochrome in a rat substantia nigra neuronal cell line 

      Dagnino Subiabre, Alexies; Marcelain Cubillos, Katherine Jenny; Bennett, L. B.; Caviedes Fernández, Pablo; Caviedes Codelia, Raúl; Olea Azar, Claudio; Segura Aguilar, Juan; Paris Pizarro, Irmgard (BLACKWELL SCIENCE LTD, 2001-04)
      The mechanism of copper (Cu) neurotoxicity was studied in the RCSN-3 neuronal dopaminergic cell line, derived from substantia nigra of an adult rat. The formation of a Cu-dopamine complex was accompanied by oxidation of ...
    • Cu(I)–Glutathione complex: A potential source of superoxide radicals generation 

      Speisky Cosoy, Hernán; Gómez, Maritza; Carrasco Pozo, Catalina; Pastene, Edgar; López Alarcón, Camilo; Olea Azar, Claudio (PERGAMON-ELSEVIER SCIENCE LTD, 2008-07-01)
      Cu2+ ions and GSH molecules interact to swiftly form the complex Cu(I)–glutathione. We investigated the potential capacity of such complex to reduce molecular oxygen. The addition of SOD to a solution containing Cu(I)– ...
    • Cyclodextrins-Kaempferol Inclusion Complexes: Spectroscopic and Reactivity Studies 

      Jullian Matthaei, Carolina; Brossard, Victor; González, Iván; Alfaro, Muriel; Olea Azar, Claudio (SPRINGER/PLENUM PUBLISHERS, 2011-04)
      The slightly water-soluble flavonoid kaempferol (KAE) and its inclusion complexes with beta-cyclodextrin (beta CD), hydroxypropyl-beta-cyclodextrin (HP beta CD) or heptakis-2,6-O-dimethyl-beta-cyclodextrin (DM beta CD) ...