Browsing by Author "275258da-0f88-42b4-8d0f-140fefe35761"

Now showing items 1-5 of 5

    • CCL2, CCL5, and IGF-1 participate in the immunomodulation of osteogenesis during M1/M2 transition in vitro 
      Córdova Jara, Luis; Loi, Florence; Lin, Tzu-Hua; Gibon, Emmanuel; Pajarinen, Jukka; Nabeshima, Akira; Lu, Laura; Yao, Zhenyu; Goodman, Stuart B. (Wiley, 2017)
      The modulation of macrophage phenotype from pro-inflammatory (M1) to tissue healing (M2) via exogenous addition of interleukin-4 (IL-4) facilitates osteogenesis; however, the molecular mediators underlying this phenomenon ...
    • Mutant CCL2 protein coating mitigates wear particle-induced bone loss in a murine continuous polyethylene ... 
      Nabeshima, Akira; Pajarinen, Jukka; hua Lin, Tzu; Jiang, Xinyi; Gibon, Emmanuel; Córdova, Luis; Loi, Florence; Lu, Laura; Jämsen, Eemeli; Egashira, Kensuke; Yang, Fan; Yao, Zhenyu; Goodman, Stuart (Elsevier Ltd, 2017)
      Wear particle-induced osteolysis limits the long-term survivorship of total joint replacement (TJR). Monocyte/macrophages are the key cells of this adverse reaction. Monocyte Chemoattractant Protein-1 (MCP-1/CCL2) is the ...
    • NF-kappa B decoy oligodeoxynucleotide mitigates wear particle-associated bone loss in the murine continuous ... 
      Lin, Tzu-hua; Pajarinen, Jukka; Sato, Taishi; Loi, Florence; Fan, Changchun; Córdova Jara, Luis; Nabeshima, Akira; Gibon, Emmanuel; Zhang, Ruth; Yao, Zhenyu; Goodman, Stuart (Elsevier, 2016)
      Total joint replacement is a cost-effective surgical procedure for patients with end-stage arthritis. Wear particle-induced chronic inflammation is associated with the development of periprosthetic osteolysis. Modulation ...
    • Orthopaedic wear particle-induced bone loss and exogenous macrophage infiltration is mitigated by local ... 
      Lin, Tzuhua; Pajarinen, Jukka; Nabeshima, Akira; Córdova, Luis; Loi, Florence; Gibon, Emmanuel; Lu, Laura; Nathan, Karthik; Jämsen, Eemeli; Yao, Zhenyu; Goodman, Stuart (John Wiley and Sons Inc., 2017)
      Excessive production of wear particles from total joint replacements (TJRs) induces chronic inflammation, macrophage infiltration, and consequent bone loss (periprosthetic osteolysis). This inflammation and bone remodeling ...
    • Pro-inflammatory M1 macrophages promote Osteogenesis by mesenchymal stem cells via the COX-2-prostaglandin ... 
      Lu, Laura; Loi, Florence; Nathan, Karthik; Lin, Tzu; Pajarinen, Jukka; Gibon, Emmanuel; Nabeshima, Akira; Cordova, Luis; Jämsen, Eemeli; Yao, Zhenyu; Goodman, Stuart (John Wiley and Sons Inc., 2017)
      Bone fractures are among the most common orthopaedic problems that affect individuals of all ages. Immediately after injury, activated macrophages dynamically contribute to and regulate an acute inflammatory response that ...