Browsing by Author "309fa44c-c61c-4a0b-a661-1cf06fbc6777"

Now showing items 1-6 of 6

    • Angiotensin-(1–9) prevents cardiomyocyte hypertrophy by controlling mitochondrial dynamics via miR-129-3p/PKIA ... 
      Sotomayor Flores, Cristian; Rivera Mejías, Pablo; Vásquez Trincado, César; López Crisosto, Camila; Morales, Pablo E.; Pennanen, Christian; Polakovicova, Iva; Aliaga Tobar, Víctor; García Nannig, Lorena; Roa, Juan Carlos; Rothermel, Beverly A.; Maracaja Coutinho, Vinicius; Ho-Xuan, Hung; Meister, Gunter; Chiong, Mario; Ocaranza, María Paz; Corvalán, Alejandro H.; Parra Ortiz, Valentina; Lavandero González, Sergio (2020)
      Angiotensin-(1-9) is a peptide from the noncanonical renin-angiotensin system with anti-hypertrophic effects in cardiomyocytes via an unknown mechanism. In the present study we aimed to elucidate it, basing us initially ...
    • Calcium transport and signaling in mitochondria 
      Bravo Sagua, Roberto; Parra Ortíz, María Valentina; López Crisosto, Camila; Díaz, Paula; Quest, Andrew F. G.; Lavandero González, Sergio (Wiley, 2017-04)
      Calcium (Ca2+) is a key player in the regulation of many cell functions. Just like Ca2+, mitochondria are ubiquitous, versatile, and dynamic players in determining both cell survival and death decisions. Given their ...
    • Caveolin-1 impairs PKA-DRP1-mediated remodelling of ER–mitochondria communication during the early phase ... 
      Bravo Sagua, Roberto; Parra, Valentina; Ortiz-Sandoval, Carolina; Navarro Márquez, Mario F.; Rodríguez, Andrea E.; Díaz Valdivia, Natalia; Sanhueza, Carlos; López Crisosto, Camila; Tahbaz, Nasser; Rothermel, Beverly A.; Hill, Joseph A.; Cifuentes, Mariana; Simmen, Thoma (Nature Publishing Group, 2018)
      © 2018, ADMC Associazione Differenziamento e Morte Cellulare. Close contacts between endoplasmic reticulum and mitochondria enable reciprocal Ca2+ exchange, a key mechanism in the regulation of mitochondrial bioenergetics. ...
    • Inhibition of the proteasome preserves Mitofusin-2 and mitochondrial integrity, protecting cardiomyocytes ... 
      Olmedo Alegría, Ivonne; Pino Tapia, Gonzalo; Riquelme Meléndez, Jaime; Aranguiz, Pablo; Díaz, Magda C.; López Crisosto, Camila; Lavandero González, Sergio; Donoso Laurent, Paulina; Pedrozo Cibils, Zully; Sánchez Vergara, Gina (Elsevier, 2020)
      Cardiomyocyte loss is the main cause of myocardial dysfunction following an ischemia-reperfusion (IR) injury. Mitochondrial dysfunction and altered mitochondrial network dynamics play central roles in cardiomyocyte death. ...
    • mTORC1 inhibitor rapamycin and ER stressor tunicamycin induce differential patterns of ER-mitochondria coupling 
      Bravo Sagua, Roberto; López Crisosto, Camila; Parra Ortíz, María Valentina; Rodríguez Peña, Marcelo; Rothermel, Beverly A.; Quest, Andrew F. G.; Lavandero González, Sergio (Nature, 2016)
      Efficient mitochondrial Ca2+ uptake takes place at contact points between the ER and mitochondria, and represents a key regulator of many cell functions. In a previous study with HeLa cells, we showed that ER-to-mitochondria ...
    • Regulación del acoplamiento mitocondriaretículo endoplásmico y el metabolismo mitocondrial durante el estrés ... 
      López Crisosto, Camila (Universidad de Chile, 2017)
      La acumulación de proteínas mal plegadas dentro de las mitocondrias genera una respuesta transcripcional adaptativa, denominada UPR mitocondrial. A través de esta respuesta, las mitocondrias señalizan hacia el núcleo para ...