Now showing items 1-3 of 3

    • Mella Raipán, Jaime; Romero Parra, Javier; Recabarren Gajardo, Gonzalo (American Chemical Society, 2020)
      Opioids are arguably one of the most important pharmacologic classes, mainly due to their rich history, their useful and potent analgesic effects, and also, just as importantly, their “Dark Side”, constituted by their ...
    • Cerda Cavieres, Christopher David; Quiroz, Gabriel; Iturriaga-Vásquez, Patricio; Rodríguez Lavado, Julio; Alarcón Espósito, Jazmín; Saitz Barría, Claudio; Pessoa Mahana, Carlos D.; Chung, Hery; Araya Maturana, Ramiro; Mella Raipán, Jaime A.; Cabezas, David; Ojeda Gómez, Claudia; Reyes Parada, Miguel; Pessoa Mahana, Hernán (MDPI, 2020)
      A series of 27 compounds of general structure 2,3-dihydro-benzo[1,4]oxazin-4-yl)-2-{4-[3-(1H-3indolyl)-propyl]-1-piperazinyl}-ethanamides, Series I: 7(a-o) and (2-{4-[3-(1H-3-indolyl)-propyl]-1-piperazinyl}-acetylamine)- ...
    • Rodríguez Lavado, Julio; Gallardo Garrido, Carlos; Mallea Catalán, Michael; Bustos, Víctor; Osorio, Rodrigo; Hödar Salazar, Martín; Chung, Hery; Araya Maturana, Ramiro; Lorca, Marcos; Pessoa Mahana, C. David; Mella Raipán, Jaime; Saitz Barría, Claudio; Jaque Olmedo, Pablo; Reyes Parada, Miguel; Iturriaga-Vásquez, Patricio; Pessoa Mahana, Hernán (Elsevier, 2020)
      During the last decade, the one drug-one target strategy has resulted to be inefficient in facing diseases with complex ethiology like Alzheimer's disease and many others. In this context, the multitarget paradigm has ...