Now showing items 1-9 of 9

    • Advances in Fetal and Neonatal Physiology 

      Giussani, Dino A.; Niu, Youguo; Herrera Videla, Emilio; Richter, Hans G.; Camm, Emily J.; Thakor, Avnesh S.; Kane, Andrew D.; Hansell, Jeremy A.; Brain, Kirsty L.; Skeffington, Katie L.; Itani, Nozomi; Wooding, F. B. Peter; Cross, Christine M.; Allison, Beth J. (Springer, 2014)
      The quality of the intrauterine environment interacts with our genetic makeup to shape the risk of developing disease in later life. Fetal chronic hypoxia is a common complication of pregnancy. This chapter reviews how ...
    • Developmental programming of cardiovascular dysfunction by prenatal hypoxia and oxidative stress 

      Giussani, Dino A.; Camm, Emily J.; Niu, Youguo; Richter, Hans G.; Blanco, Carlos E.; Gottschalk, Rachel; Blake, E. Zachary; Horder, Katy A.; Thakor, Avnesh S.; Hansell, Jeremy A.; Kane, Andrew D.; Wooding, F. B.Peter; Cross, Christine M.; Herrera, Emilio A. (2012)
      Fetal hypoxia is a common complication of pregnancy. It has been shown to programme cardiac and endothelial dysfunction in the offspring in adult life. However, the mechanisms via which this occurs remain elusive, precluding ...
    • Impaired Nitric Oxide Mediated Vasodilation in the Peripheral Circulation in the R6/2 Mouse Model of Huntington's Disease 

      Kane, Andrew D.; Niu, Youguo; Herrera, Emilio A.; Morton, A. Jennifer; Giussani, Dino A. (Nature Publishing Group, 2016)
      © 2016, Nature Publishing Group. All rights reserved. Recent evidence shows that the Huntington's disease (HD) extends beyond the nervous system to other sites, including the cardiovascular system. Further, the cardiovascular ...
    • Impaired Nitric Oxide Mediated Vasodilation In The Peripheral Circulation In The R6/2 Mouse Model Of Huntington's Disease 

      Kane, Andrew D.; Niu, Youguo; Herrera Videla, Emilio; Morton, A. Jennifer; Giussani, Dino A. (Nature, 2016)
      Recent evidence shows that the Huntington's disease (HD) extends beyond the nervous system to other sites, including the cardiovascular system. Further, the cardiovascular pathology pre-dates neurological decline, however ...
    • Induction of controlled hypoxic pregnancy in large mammalian species 

      Brain, Kirsty L.; Allison, Beth J.; Niu, Youguo; Cross, Christine M.; Itani, Nozomi; Kane, Andrew D.; Herrera, Emilio A.; Giussani, Dino A. (American Physiological Society, 2015)
      © 2015 The Authors. Progress in the study of pregnancy complicated by chronic hypoxia in large mammals has been held back by the inability to measure long-term significant reductions in fetal oxygenation at values similar ...
    • Maternal chronic hypoxia increases expression of genes regulating lung liquid movement and surfactant maturation in male fetuses in late gestation 

      McGillick, Erin V.; Orgeig, Sandra; Allison, Beth J.; Brain, Kirsty L.; Niu, Youguo; Itani, Nozomi; Skeffington, Katie L.; Kane, Andrew D.; Herrera Videla, Emilio; Giussani, Dino A.; Morrison, Janna L. (Wiley, 2017)
      Chronic fetal hypoxaemia is a common pregnancy complication that may arise from maternal, placental and/or fetal factors. Respiratory outcome of the infant at birth likely depends on the duration, timing and severity of ...
    • Maternal-to-fetal allopurinol transfer and xanthine oxidase suppression in the late gestation pregnant rat 

      Kane, Andrew D.; Camm, Emily J.; Richter, Hans G.; Lusby, Ciara; Tijsseling, Deodata; Kaandorp, Joepe J.; Derks, Jan B.; Ozanne, Susan E.; Giussani, Dino A. (American Physiological Society, 2013)
      © 2013 The Authors. Fetal brain hypoxic injury remains a concern in high-risk delivery. There is significant clinical interest in agents that may diminish neuronal damage during birth asphyxia, such as in allopurinol, an ...
    • Weak cardiovascular defence to hypotensive stress in the chronically hypoxic fetus 

      Allison, Beth J.; Brain, Kirsty L.; Niu, Youguo; Kane, Andrew D.; Herrera Videla, Emilio; Botting, Kimberley J.; Cross, Christine M.; Itani, Nozomi; Skeffington, Katie L.; Giussani, Dino A. (Sage Pubications INC, 2018)
    • Xanthine oxidase and the fetal cardiovascular defence to hypoxia in late gestation ovine pregnancy 

      Kane, Andrew D.; Hansell, Jeremy A.; Herrera, Emilio A.; Allison, Beth J.; Niu, Youguo; Brain, Kirsty L.; Kaandorp, Joepe J.; Derks, Jan B.; Giussani, Dino A. (2014)
      Hypoxia is a common challenge to the fetus, promoting a physiological defence to redistribute blood flow towards the brain and away from peripheral circulations. During acute hypoxia, reactive oxygen species (ROS) interact ...