Browsing by Author "4e8c028b-ca3e-4881-bba0-17182c63f779"

Now showing items 1-3 of 3

    • Complex mitochondrial dysfunction induced by TPP+-gentisic acid and mitochondrial translation inhibition ... 
      Fuentes Retamal, Sebastián; Sandoval Acuña, Cristian; Peredo Silva, Liliana; Guzmán Rivera, Daniela; Pavani, Mario; Torrealba, Natalia; Truksa, Jaroslav; Castro Castillo, Vicente; Catalán Díaz, Mabel; Kemmerling Weis, Ulrike; Urra Faúndez, Félix; Ferreira, Jorge (MDPI, 2020)
      The mitochondrion has emerged as a promising therapeutic target for novel cancer treatments because of its essential role in tumorigenesis and resistance to chemotherapy. Previously, we described a natural compound, ...
    • Derivatives of alkyl gallate triphenylphosphonium exhibit antitumor activity in a syngeneic murine model ... 
      Peredo Silva, Liliana; Fuentes Retamal, Sebastián; Sandoval Acuña, Cristian; Pavani Costa, Mario; Maya Arango, Juan; Castro Castillo, Vicente; Madrid Rojas, Matías; Rebolledo, Solange; Kemmerling Weis, Ulrike; Parra, Eduardo; Ferreira Parker, Jorge (Elsevier, 2017)
      We previously demonstrated that alkyl gallates coupled to triphenylphosphine have a selective and efficient antiproliferative effect by inducing mitochondria] uncoupling in vitro due to the increased mitochondrial trans ...
    • Destabilization of mitochondrial functions as a target against breast cancer progression: Role of ... 
      Sandoval Acuña, Cristian; Fuentes Retamal, Sebastián; Guzmán Rivera, Daniela; Peredo Silva, Liliana; Madrid Rojas, Matías; Rebolledo, Solange; Castro Castillo, Vicente; Pavani, Mario; Catalán, Mabel; Maya Arango, Juan; Jara, Jose A.; Parra, Eduardo; Calaf, Gloria M.; Speisky Cosoy, Hernán; Ferreira Parker, Jorge (2016)
      Mitochondrion is an accepted molecular target in cancer treatment since it exhibits a higher transmembrane potential in cancer cells, making it susceptible to be targeted by lipophilic-delocalized cations of triphenylphosphonium ...