Now showing items 1-8 of 8

    • An integrated mechanism of cardiomyocyte nuclear Ca2+ signaling 

      Ibarra, Cristián; Vicencio Bustamante, José Miguel; Varas Godoy, Manuel; Jaimovich Pérez, Enrique; Rothermel, Beverly A.; Uhlén, Per; Hill, Joseph A.; Lavandero González, Sergio (Academic Press, 2014)
      © 2014 Elsevier Ltd. In cardiomyocytes, Ca2+ plays a central role in governing both contraction and signaling events that regulate gene expression. Current evidence indicates that discrimination between these two critical ...
    • GSK-3β/NFAT Signaling is involved in testosterone-induced cardiac myocyte hypertrophy 

      Durán, Javier; Oyarce Díaz, César; Pavez Giani, Mario; Valladares, Denisse; Basualto Alarcón, Carla; Lagos, Daniel; Barrientos Briones, Genaro; Troncoso Magñin, Mayarling; Ibarra, Cristián; Estrada Hormazábal, Manuel; Basualto Alarcón, Carla (Public Library Science, 2016-12-15)
      Testosterone induces cardiac hypertrophy through a mechanism that involves a concerted crosstalk between cytosolic and nuclear signaling pathways. Nuclear factor of activated Tcells (NFAT) is associated with the promotion ...
    • IGF-1: Un factor de crecimiento con acciones cardiovasculares pleiotrópicas. 

      Contreras Ferrat, Ariel Eduardo; Aránguiz Urroz, Pablo Daniel; Díaz Elizondo, Jessica; Chiong Lay, Mario; Muñoz, Juan Pablo; Parra Ortíz, María Valentina; Ibarra, Cristián; Rojas Rivera, Diego; Troncoso Cotal, Rodrigo; Eisner, Verónica; Salas, Daniela; Rodríguez Villarroel, Andrea Elizabeth; Carrasco Alarcón, Loreto del Pilar; Díaz Araya, Guillermo; Lavandero González, Sergio (Sociedad Chilena de Cardiología y Cirugía Cardiovascular, 2006)
      El factor de crecimiento análogo a insulina tipo 1 (IGF-1) es un péptido relacionado estructural y funcionalmente con insulina que posee efectos mitogénicos y citoprotectores. Sus efectos biológicos dependen de la activación ...
    • An Inositol 1,4,5-Triphosphate (IP3)-IP3 Receptor Pathway Is Required for Insulin-Stimulated Glucose Transporter 4 Translocation and Glucose Uptake in Cardiomyocytes 

      Contreras Ferrat, Ariel Eduardo; Toro, Barbra; Bravo, R.; Parra Ortíz, María Valentina; Vásquez, C.; Ibarra, Cristián; Mears, David; Chiong Lay, Mario; Jaimovich Pérez, Enrique; Klip, Amira; Lavandero González, Sergio (ENDOCRINE SOC, 2010-10)
      Intracellular calcium levels ([Ca2+](i)) and glucose uptake are central to cardiomyocyte physiology, yet connections between them have not been studied. We investigated whether insulin regulates [Ca2+](i) in cultured ...
    • Insulin-like growth factor-1 induces an inositol 1,4,5-trisphosphate-dependent increase in nuclear and cytosolic calcium in cultured rat cardiac myocytes 

      Ibarra, Cristián; Estrada Hormazábal, Manuel; Carrasco Mujica, Loreto; Chiong Lay, Mario; Liberona Leppe, José; Cárdenas, César; Díaz Araya, Guillermo; Jaimovich Pérez, Enrique; Lavandero González, Sergio (Amer Biochemistry Molecular Biology, 2004-02-27)
      In the heart, insulin-like growth factor-1 (IGF-1) is a pro-hypertrophic and anti-apoptotic peptide. In cultured rat cardiomyocytes, IGF-1 induced a fast and transient increase in Ca-i(2+) levels apparent both in the nucleus ...
    • New insights into IGF-1 signaling in the heart 

      Troncoso Cotal, Rodrigo Hernán; Ibarra, Cristián; Vicencio, José Miguel; Jaimovich Pérez, Enrique; Lavandero González, Sergio (Elsevier, 2014)
      Insulin-like growth factor 1 (IGF-1) signaling regulates contractility, metabolism, hypertrophy, autophagy, senescence, and apoptosis in the heart. IGF-1 deficiency is associated with an increased risk of cardiovascul ...
    • A novel dihydropyridine with 3-aryl meta-hydroxyl substitution blocks L-type calcium channels in rat cardiomyocytes 

      Galvis Pareja, David; Zapata Torres, Gerald; Hidalgo Tapia, Jorge; Ayala, Pedro; Pedrozo Cibils, Zully; Ibarra, Cristián; Díaz Araya, Guillermo; Hall, Andrew R.; Vicencio, José Miguel; Núñez Vergara, Luis; Lavandero González, Sergio (Elsevier, 2014)
      Rationale: Dihydropyridines are widely used for the treatment of several cardiac diseases due to their blocking activity on L-type Ca2+ channels and their renowned antioxidant properties. Methods: We synthesized six novel ...
    • Testosterone induces an intracellular calcium increase by a nongenomic mechanism in cultured rat cardiac myocytes 

      Vicencio, José Miguel; Ibarra, Cristián; Estrada Hormazábal, Manuel; Chiong Lay, Mario; Soto, Dagoberto; Parra, Valentina; Díaz Araya, Guillermo; Jaimovich Pérez, Enrique; Lavandero González, Sergio (ENDOCRINE SOC, 2006-03)
      Androgens are associated with important effects on the heart, such as hypertrophy or apoptosis. These responses involve the intracellular androgen receptor. However, the mechanisms of how androgens activate several membrane ...