Browsing by Author "63c5a1f4-2c82-4cb3-8f3e-b4193b4ef880"

Now showing items 1-3 of 3

    • Independent Anti-Angiogenic Capacities of Coagulation Factors X and Xa 
      Lange, Soledad; Gonzalez, Ibeth; Pinto, Mauricio P.; Arce, Maximiliano; Valenzuela, Rodrigo; Aranda, Evelyn; Elliot, Matias; Alvarez, Marjorie; Henriquez, Soledad; Velasquez, Ethel V.; Orge, Felipe; Oliva, Barbara; Gonzalez, Pamela; Villalon, Manuel; Cautivo, Kelly M.; (Wiley-Liss Inc., 2014)
      Knockout models have shown that the coagulation system has a role in vascular development and angiogenesis. Herein, we report for the first time that zymogen FX and its active form (FXa) possess anti-angiogenic properties. ...
    • Molecular modelling predicts that 2-methoxyestradiol disrupts HIF function by binding to the PAS-B domain 
      Poch, Andrea; Villanelo, Felipe; Henriquez, Soledad; Kohen Skop, Paulina; Ferrada Muñoz, Alex Eduardo; Strauss, Jerome F.; Devoto, Luigi (Elsevier Inc., 2019)
      An estradiol metabolite, 2-methoxyestradiol (2ME), has emerged as an important regulator of ovarian physiology. 2ME is recognized as a potent anti-angiogenic agent in clinical trials and laboratory studies. However, little ...
    • Progesterone promotes focal adhesion formation and migration in breast cancer cells through induction of ... 
      Diaz, Jorge; Aranda, Evelyn; Henriquez, Soledad; Quezada, Marisol; Espinoza, Estefanía; Bravo, Maria Loreto; Oliva, Bárbara; Lange, Soledad; Villalon, Manuel; Jones, Marius; Brosens, Jan J.; Kato, Sumie; Cuello, Mauricio A.; Knutson, Todd P.; Lange, Carol A.; Leyton, Li (2012)
      Progesterone and progestins have been demonstrated to enhance breast cancer cell migration, although the mech- anisms are still not fully understood. The protease-activated receptors (PARs) are a family of membrane receptors ...