Browsing by Author "6980edc5-3ada-4d6e-bd69-8175a6f09ea7"

Now showing items 1-20 of 21

    • Applicability of ENCHANTED trial results to current acute ischemic stroke patients eligible for intravenous ... 
      Robinson, Thompson G.; Bray, Benjamin D.; Paley, Lizz; Sprigg, Nikola; Wang, Xia; Arima, Hisatomi; Bath, Philip M.; Broderick, Joseph P.; Durham, Alice C.; Kim, Jong S.; Lavados Germain, Pablo Manuel; Lee, Tsong Hai; Martins, Sheila; Nguyen, Thang H.; Pandian, Jeyaraj D.; Parsons, (SAGE Publications Inc., 2019)
      Background: Randomized controlled trials provide high-level evidence, but the necessity to include selected patients may limit the generalisability of their results. Methods: Comparisons were made of baseline and outcome ...
    • Blood pressure variability and outcome in acute ischemic and hemorrhagic stroke: a post hoc analysis of the ... 
      Minhas, Jatinder S.; Wang, Xia; Lavados Germain, Pablo Manuel; Moullaali, Tom J.; Arima, Hisatomi; Billot, Laurent; Hackett, Maree L.; Olavarria, Veronica V.; Middleton, Sandy; Pontes-Neto, Octavio; De Silva, H. Asita; Lee, Tsong Hai; Pandian, Jeyaraj D.; Mead, Gillian E.; Watkins (Nature Publishing Group, 2019)
      The Head Positioning in Acute Stroke Trial (HeadPoST) is a pragmatic, international, cluster crossover randomized trial of 11,093 patients with acute stroke assigned to a lying-flat (0°) or sitting-up (head elevated ≥30°) ...
    • Characteristics, management and response to alteplase in China versus non-China participants of the ENCHANTED trial 
      Song, Lily; Wang, Xia; Robinson, Thompson; Lindley, Richard I.; Arima, Hisatomi; Lavados Germain, Pablo Manuel; Chen, Xiaoying; Chalmers, John; Anderson, Craig S.; Anderson, Craig S. (BMJ Publishing Group, 2017)
      © 2017 BMJ Publishing Group. All rights reserved. Background The characteristics of patients with acute ischaemic stroke (AIS) and their management vary across regions, which may influence outcomes. We examined for ...
    • Early Blood Pressure Lowering Does Not Reduce Growth of Intraventricular Hemorrhage following Acute ... 
      Chan, Edward; Anderson, Craig S.; Wang, Xia; Arima, Hisatomi; Saxena, Anubhav; Moullaali, Tom J.; Delcourt, Candice; Wu, Guojun; Wang, Jinchao; Chen, Guofang; Lavados Germain, Pablo Manuel; Stapf, Christian; Robinson, Thompson; Chalmers, John (S. Karger AG, 2016)
      © 2016 The Author(s). Background: Intraventricular hemorrhage (IVH) extension is common following acute intracerebral hemorrhage (ICH) and is associated with poor prognosis. Aim: To determine whether intensive blood pressure ...
    • Early blood pressure lowering in patients with intracerebral haemorrhage and prior use of antithrombotic ... 
      Lili, Song; Sandset, Else Charlotte; Arima, Hisatomi; Heeley, Emma; Delcourt, Candice; Chen, Guofeng; Yang, Jie; Wu, Guojun; Wang, Xia; Lavados Germain, Pablo Manuel; Huang, Yining; Stapf, Christian; Wang, Jiguang; Robinson, Thompson; Chalmers, John; Lindley, Richard I.; Anderson, Craig S. (BMJ Publishing Group, 2016-12)
      Objective Antithrombotic agents increase risks of intracerebral haemorrhage (ICH) and associated adverse outcomes. We determined differential effects of early blood pressure (BP) lowering in patients with/without ...
    • Ethnicity and other determinants of quality of functional outcome in acute ischemic stroke: The ENCHANTED trial. 
      Chen, Xiaoying; Wang, Xia; Delcourt, Candice; Li, Jingwei; Arima, Hisatomi; Hackett, Maree L.; Robinson, L.; Lavados, Pablo M.; Lindley, Richard I.; Chalmers, John; Anderson, Craig S. (Lippincott Williams & Wilkins, 2020)
      Background and Purpose-Patient-centered outcomes are important. We aimed to determine predictors of health-related quality of life (HRQoL) and develop utility-weighted modified Rankin Scale (mRS) scores in thrombolyzed ...
    • Frequency, determinants, and effects of early seizures after thrombolysis for acute ischemic stroke The ... 
      Xu, Ying; Hackett, Maree L.; Chalmers, John; Lindley, Richard I.; Wang, Xia; Li, Qiang; Robinson, Thompson; Arima, Hisatomi; Lavados Germain, Pablo Manuel; Anderson, Craig S. (Lippincott Williams & Wilkins, 2017)
      Background: Seizures after ischemic stroke have not been well-studied. We aim to determine the frequency, determinants, and significance of early seizures after thrombolysis for acute ischemic stroke. Methods: Data are ...
    • Head position and cerebral blood flow velocity in acute ischemic stroke: A systematic review and meta-analysis 
      Olavarría, Verónica V.; Arima, Hisatomi; Anderson, Craig S.; Brunser, Alejandro M.; Muñoz-Venturelli, Paula; Heritier, Stephane; Lavados Germain, Pablo Manuel (S. Karger AG, 2014)
      Background: Patients with acute ischemic stroke (AIS) have impaired vasomotor reactivity, especially in the affected cerebral hemisphere, such that they may depend directly on systemic blood pressure to maintain perfusion ...
    • Intensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke ... 
      Anderson, Craig S.; Huang, Yining; Lindley, Richard I.; Chen, Xiaoying; Arima, Hisatomi; Chen, Guofang; Li, Qiang; Billot, Laurent; Delcourt, Candice; Bath, Philip M.; Broderick, Joseph P.; Demchuk, Andrew M.; Donnan, Geoffrey A.; Durham, Alice C.; Lavados Germain, Pablo Manuel (Lancet Publishing Group, 2019)
      Background: Systolic blood pressure of more than 185 mm Hg is a contraindication to thrombolytic treatment with intravenous alteplase in patients with acute ischaemic stroke, but the target systolic blood pressure for ...
    • Intracerebral hemorrhage location and outcome among INTERACT2 participants 
      Delcourt, Candice; Sato, Shoichiro; Zhang, Shihong; Sandset, Else Charlotte; Zheng, Danni; Chen, Xiaoying; Hackett, Maree L.; Arima, Hisatomi; Hata, Jun; Heeley, Emma; Salman, Rustam Al Shahi; Robinson, Thompson; Davies, Leo; Lavados Germain, Pablo Manuel; Lindley, Richard I.; Stap (Lippincott Williams and Wilkins, 2017)
      © 2017 The Author(s).Objective: To clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase Intensive Blood Pressure Reduction in Acute Cerebral ...
    • Low-versus standard-dose alteplase in patients on prior antiplatelet therapy: the Enchanted trial (enhanced ... 
      Robinson, Thompson G.; Wang, Xia; Arima, Hisatomi; Bath, Philip M.; Billot, Laurent; Broderick, Joseph P.; Demchuk, Andrew M.; Donnan, Geoffery A.; Kim, Jong S.; Lavados Germain, Pablo Manuel; Lee, Tsong Hai; Lindley, Richard I.; Martins, Sheila C. O.; Olavarria, Veronica V.; Pandian, Jeyaraj D.; Parsons, Mark W.; Pontes Neto, Octavio M.; Ricci, Stefano; Sato, Shoichiro; Sharma, Vijay K.; Nguyen, Thang H.; Wang, Ji Guang; Woodward, Mark; Chalmers, John; Anderson, Craig S. (Lippincott Williams & Wilkins, 2017)
      Background and Purpose-Many patients receiving thrombolysis for acute ischemic stroke are on prior antiplatelet therapy (APT), which may increase symptomatic intracerebral hemorrhage risk. In a prespecified subgroup analysis, ...
    • Mannitol and outcome in intracerebral hemorrhage: Propensity score and multivariable intensive blood pressure ... 
      Wang, Xia; Arima, Hisatomi; Yang, Jie; Zhang, Shihong; Wu, Guojun; Woodward, Mark; Muñoz Venturelli, Paula; Lavados Germain, Pablo Manuel; Stapf, Christian; Robinson, Thompson; Heeley, Emma; Delcourt, Candice; Lindley, Richard I.; Parsons, Mark; Chalmers, John; Anderson, Craig S. (Lippincott Williams and Wilkins, 2015)
      © 2015 American Heart Association, Inc. Background and Purpose.Mannitol is often used to reduce cerebral edema in acute intracerebral hemorrhage but without strong supporting evidence of benefit. We aimed to determine the ...
    • Positive impact of the participation in the Enchanted trial in reducing door to needle time 
      Yang, Jie; Wang, Xia; Yu, Jian Ping; Hang, Jing; Lavados Germain, Pablo Manuel; Robinson, Thompson; Arima, Hisatomi; Lindley, Richard I.; Anderson, Craig S.; Chalmers, John (Nature Publishing Group, 2017)
      Door-to-needle time (DNT) is a key performance indicator for efficient use of intravenous thrombolysis in acute ischemic stroke (AIS). We aimed to determine whether DNT improved over time in the Enhanced Control of ...
    • Practice patterns for neurosurgical utilization and outcome in acute intracerebral hemorrhage: intensive ... 
      Guo, Rui; Blacker, David J.; Wang, Xia; Arima, Hisatomi; Lavados Germain, Pablo Manuel; Lindley, Richard I.; Chalmers, John; Anderson, Craig S.; Robinson, Thompson (Oxford university press, 2017)
      BACKGROUND: The prognosis in acute spontaneous intracerebral hemorrhage (ICH) is related to hematoma volume, where >30 mL is commonly used to define large ICH as a threshold for neurosurgical decompression but without clear ...
    • Prognostic Significance of Hyperglycemia in Acute Intracerebral Hemorrhage: The INTERACT2 Study 
      Saxena, Anubhav; Anderson, Craig S.; Wang, Xia; Sato, Shoichiro; Arima, Hisatomi; Chan, Edward; Munoz-Venturelli, Paula; Delcourt, Candice; Robinson, Thompson; Stapf, Christian; Lavados Germain, Pablo Manuel; Wang, Jiguang; Neal, Bruce; Chalmers, John; Heeley, Emma (Lippincott Williams and Wilkins, 2016)
      © 2016 American Heart Association, Inc. We aimed to determine associations of baseline blood glucose and diabetes mellitus with clinical outcomes in participants of the Intensive Blood Pressure Reduction in Acute Cerebral ...
    • Rationale, design, and progress of the ENhanced Control of Hypertension ANd Thrombolysis strokE stuDy ... 
      Huang, Yining; Sharma, Vijay K.; Robinson, Thompson; Lindley, Richard I.; Chen, Xiaoying; Kim, Jong Sung; Lavados Germain, Pablo Manuel; Olavarría, Verónica; Arima, Hisatomi; Fuentes, Sully; Nguyen, Huy Thang; Lee, Tsong Hai; Parsons, Mark W.; Levi, Christopher; Demchuk, Andrew M. (Blackwell Publishing Ltd, 2015)
      © 2015 World Stroke Organization. Rationale: Controversy exists over the optimal dose of intravenous (iv) recombinant tissue plasminogen activator (rt-PA) and degree of blood pressure (BP) control in acute ischaemic stroke ...
    • Regional variation in acute stroke care organisation 
      Muñoz Venturelli, Paula; Robinson, Thompson; Lavados Germain, Pablo Manuel; Olavarría, Verónica V.; Arima, Hisatomi; Billot, Laurent; Hackett, Maree L.; Lim, Joyce Y.; Billot, Laurent; Hackett, Maree L.; Lim, Joyce Y.; Middleton, Sandy; Pontes Neto, Octavio; Peng, Bin; Cui, Liying; Song, Lily; Mead, Gillian; Watkins, Caroline; Lin, Ruey Tay; Lee, Tsong Hai; Pandian, Jeyaraj; de Silva, H. Asita; Anderson, Craig S. (Elsevier, 2016-12)
      Few studies have assessed regional variation in the organisation of stroke services, particularly health care resourcing, presence of protocols and discharge planning. Our aim was to compare stroke care organisation within ...
    • Significance of intraventricular hemorrhage in Acute intracerebral hemorrhage intensive Blood Pressure ... 
      Chan, Edward; Anderson, Craig S.; Wang, Xia; Arima, Hisatomi; Saxena, Anubhav; Moullaali, Tom J.; Heeley, Emma; Delcourt, Candice; Wu, Guojun; Wang, Jinchao; Chen, Guofang; Lavados Germain, Pablo Manuel; Stapf, Christian; Robinson, Thompson; Chalmers, John; Huang, Yining (Lippincott Williams and Wilkins, 2015)
      © 2015 American Heart Association, Inc. Background and Purpose: Intraventricular hemorrhage (IVH) with spontaneous intracerebral hemorrhage indicates a poor prognosis but uncertainty exists over the pattern of association. ...
    • Statistical analysis plan for the head position in stroke trial (HeadPoST): an international cluster cross ... 
      Billot, Laurent; Woodward, Mark; Arima, Hisatomi; Lavados Germain, Pablo Manuel (Sage Publications, 2017)
      Background: There is evidence to indicate that the lying flat head position increases cerebral blood flow and oxygenation in patients with acute ischemic stroke, but how these physiological effects translate into clinical ...
    • Statistical analysis plan of the head position in acute ischemic stroke trial pilot (HEADPOST pilot) 
      Olavarría, Verónica V.; Arima, Hisatomi; Anderson, Craig S.; Brunser, Alejandro; Muñoz Venturelli, Paula; Billot, Laurent; Lavados Germain, Pablo Manuel (SAGE Publications Inc., 2017)
      © 2016, © 2016 World Stroke Organization. Background: The HEADPOST Pilot is a proof-of-concept, open, prospective, multicenter, international, cluster randomized, phase IIb controlled trial, with masked outcome assessment. ...