Browsing by Author "6a9f283b-22c6-4a64-9154-d63bc5b2ec6e"

Now showing items 1-7 of 7

    • Chronic bryostatin‑1 rescues autistic and cognitive phenotypes in the fragile X mice 
      Cogram, Patricia; Alkon, Daniel L.; Crockford, David; Deacon, Robert M.J.; Hurley, Michael J.; Altimiras, Francisco; Sun, Miao‑Kun; Tranfaglia, Michael (Nature, 2020)
      Fragile X syndrome (FXS), an X-chromosome linked intellectual disability, is the leading monogenetic cause of autism spectrum disorder (ASD), a neurodevelopmental condition that currently has no specific drug treatment. ...
    • Dementia in Latin America: assessing the present and envisioning the future 
      Parra, Marrio A.; Baez, Sandra; Allegri, Ricardo; Nitrini, Ricardo; Lopera, Francisco; Slachevsky Chonchol, Andrea; Custodio, Nilton; Lira, David; Piguet, Olivier; Kumfor, Fiona; Huepe, David; Cogram, Patricia; Bak, Thomas; Manes, Facundo; Ibañez, Agustín (Lippincott Williams & Wilkins, 2018)
      The demographic structure of Latin American countries (LAC) is fast approaching that of developing countries, and the predicted prevalence of dementia in the former already exceeds the latter. Dementia has been declared a ...
    • Editorial: human and animal models for translational research on neurodegeneration: challenges and opportunities ... 
      Ibáñez, Agustín; Sedeño, Lucas; García, Adolfo M.; Deacon, Robert M. J.; Cogram, Patricia (Frontiers media SA, 2018)
    • Multiple behavior phenotypes of the fragile - X syndrome mouse model respond to chronic inhibition of ... 
      Gurney, Mark E.; Cogram, Patricia; Deacon, Robert M.; Rex, Christopher; Tranfaglia, Michael (Nature Publishing Group, 2017)
      Fragile-X syndrome (FXS) patients display intellectual disability and autism spectrum disorder due to silencing of the X-linked, fragile-X mental retardation-1 (FMR1) gene. Dysregulation of cAMP metabolism is a consistent ...
    • Nrf2: a novel therapeutic target in fragile X syndrome is modulated by NNZ2566 
      Deacon, R. M. J.; Hurley, M. J.; Rebolledo, C. M.; Snape, M.; Altimiras, F. J.; Farias, L.; Pino, M.; Biekofsky, R.; Glass, L.; Cogram, Patricia (Wiley, 2017)
      Fragile X-associated disorders are a family of genetic conditions resulting from the partial or complete loss of fragile X mental retardation protein (FMRP). Among these disorders, fragile X syndrome (FXS) is the most ...
    • Repurposing available drugs for neurodevelopmental disorders: The fragile X experience 
      Tranfaglia, Michael R.; Thibodeaux, Clare; Mason, Daniel J.; Brown, David; Roberts, Ian; Smith, Richard; Guilliams, Tim; Cogram, Patricia (Elsevier Ltd, 2019)
      Many available drugs have been repurposed as treatments for neurodevelopmental disorders. In the specific case of fragile X syndrome, many clinical trials of available drugs have been conducted with the goal of disease ...
    • The long-lived Octodon degus as a rodent drug discovery model for Alzheimer's and other age-related diseases 
      Hurley, Michael J.; Deacon, Robert M.J.; Beyer, Katrin; Ioannou, Elena; Ibáñez, Agustin; Teeling, Jessica L.; Cogram, Patricia (Elsevier Inc., 2018)
      © 2018 Elsevier Inc. Alzheimer's disease (AD) is a multifactorial progressive neurodegenerative disease. Despite decades of research, no disease modifying therapy is available and a change of research objectives and/or ...