Now showing items 1-4 of 4

    • Effects of ATP, Mg2+, and redox agents on the Ca2+ dependence of RyR channels from rat brain cortex 

      Bull Simpfendorfer, Ricardo; Finkelstein, José Pablo; Humeres, Alexis; Behrens Pellegrino, María Isabel; Hidalgo Tapia, María Cecilia (AMER PHYSIOLOGICAL SOC, 2007-07)
      Despite their relevance for neuronal Ca2+-induced Ca2+ release (CICR), activation by Ca2+ of ryanodine receptor (RyR) channels of brain endoplasmic reticulum at the [ ATP], [Mg2+], and redox conditions present in neurons ...
    • High fat diet induced obesity produces spontaneous ventricular arrhythmias and increases the activity of ryanodine receptors in mice 

      Sánchez Vergara, Gina; Araneda, Felipe; Peña, Juan Pedro; Finkelstein, José Pablo; Riquelme, Jaime A.; Montecinos, Luis; Barrientos Briones, Genaro; Llanos Vidal, Paola; Pedrozo Cibils, Zully; Said, Matilde; Bull Simpfendorfer, Ricardo; Donoso Laurent, Paulina (MDPI, 2018)
      Ventricular arrhythmias are a common cause of sudden cardiac death, and their occurrence is higher in obese subjects. Abnormal gating of ryanodine receptors (RyR2), the calcium release channels of the sarcoplasmic reticulum, ...
    • Ischemia Enhances Activation by Ca2+ and Redox Modification of Ryanodine Receptor Channels from Rat Brain Cortex 

      Bull Simpfendorfer, Ricardo; Finkelstein, José Pablo; Gálvez, Jorge; Sánchez, Gina; Donoso Laurent, Paulina; Behrens Pellegrino, María Isabel; Hidalgo Tapia, María Cecilia (2008)
      Cerebral ischemia stimulates Ca2+influx and thus increases neuronal intracellular free [Ca2+. Using a rat model of cerebral ischemia without recirculation, we tested whether ischemia enhances the activation by Ca2+ of ...
    • Redox-sensitive stimulation of type-1 ryanodine receptors by the scorpion toxin maurocalcine 

      Ronjat, Michel; Finkelstein, José Pablo; Llanos Vidal, Paola; Montecinos, Luis; Bichraoui, Hicham; Waard, Michel De; Hidalgo Tapia, María Cecilia; Bull Simpfendorfer, Ricardo (Elsevier, 2013)
      The scorpion toxin maurocalcine acts as a high affinity agonist of the type-1 ryanodine receptor expressed in skeletal muscle. Here, we investigated the effects of the reducing agent dithiothreitol or the oxidizing reagent ...