Now showing items 1-20 of 27

    • Anti-trypanosomatid benzofuroxans and deoxygenated analogues: Synthesis using polymer-supported triphenylphosphine, biological evaluation and mechanism of action studies 

      Castro, Diego; Boiani, Lucía; Benítez, Diego; Hernández, Paola; Merlino, Alicia; Gil, Carmen; Olea Azar, Claudio; González, Mercedes; Cerecetto, Hugo; Porcal, Williams (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2009-12)
      Hybrid vinylthio-, vinylsulfinyl-, vinylsulfonyl- and vinylketo-benzofuroxans developed as anti-trypanosomatid agents, against Trypanosoma cruzi and Leishmania spp., have showed low micromolar IC50 values. The synthetic ...
    • Comparative spectroscopic and electrochemical study of nitroindazoles: 3-Alcoxy, 3-hydroxy and 3-oxo derivatives 

      Rodríguez Borges, Jorge; Olea Azar, Claudio; Barriga, Germán; Folch, Christian; Gerpe, Alejandra; Cerecetto, Hugo; González, Mercedes (PERGAMON-ELSEVIER SCIENCE LTD, 2008-08)
      Cyclic voltammetry and electron spin resonance techniques were used in the investigation of novel 3-alkoxy- and 3-hydroxy-1-[omega-(dialkylamino)alkyl]-5-nitroindazole derivatives. A self-protonation process involving the ...
    • Effect of ruthenium complexation on trypanocidal activity of 5-nitrofuryl containing thiosemicarbazones 

      Pagano, Mariana; Demoro, Bruno; Toloza, Jeannette; Boiani, Lucía; González, Mercedes; Cerecetto, Hugo; Olea Azar, Claudio; Norambuena, Ester; Gambino, Dinorah; Otero, Lucía (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2009-12)
      In the search of new therapeutic tools for the treatment of American Trypanosomiasis, the largest parasitic disease burden in the American continent, three series of novel ruthenium complexes of the formula [RuCl2(HL)(2)], ...
    • ESR and electrochemical study of 5-nitroindazole derivatives with antiprotozoal activity 

      Olea Azar, Claudio; Cerecetto, Hugo; Gerpe, Alejandra; González, Mercedes; Arán, Vicente J.; Rigol Olsen, Carolina; Opazo, Lucía (PERGAMON-ELSEVIER SCIENCE LTD, 2006-01)
      The electrochemistry of 3-alkoxy- and 3-hydroxy-1-[(omega-(dialkylamino)alkyl]-5-nitroindazole derivatives were characterized using cyclic voltammetry in DMSO. The nitro reduction process was studied and this was affected ...
    • Heteroarylnitrones as Drugs for Neurodegenerative Diseases: Synthesis, Neuroprotective Properties, and Free Radical Scavenger Properties 

      Porcal, Williams; Hernández, Paola; González, Mercedes; Ferreira, Ana; Olea Azar, Claudio; Cerecetto, Hugo; Castro, Ana (American Chemical Society, 2008-09)
      New 1,2,4-thiadiazolylnitrones and furoxanylnitrones were developed and evaluated as neuroprotective agents on a human neuroblastoma (SH-SY5Y) cells model. They inhibited at low micromolar concentrations the oxidative ...
    • In vitro and in vivo antitrypanosomatid activity of 5-nitroindazoles 

      Boiani, Lucia; Gerpe, Alejandra; Arán, Vicente J.; Torres de Ortiz, Susana; Serna, Elva; Vera de Bilbao, Ninfa; Sanabria, Luis; Yaluff, Gloria; Nakayama, Héctor; Rojas de Arias, Antonieta; Maya Arango, Juan; Morello, J. Antonio; Cerecetto, Hugo; González, Mercedes (2009)
      Previously, we have identified a series of 5-nitroindazoles with good antiprotozoal activities, against Trypanosoma cruzi epimastigotes and Trichomonas vaginalis. Most of them have shown very low unspecific toxicity on ...
    • Indazole N-oxide derivatives as antiprotozoal agents: Synthesis, biological evaluation and mechanism of action studies 

      Gerpe, Alejandra; Aguirre, Gabriela; Boiani, Lucía; Cerecetto, Hugo; González, Mercedes; Olea Azar, Claudio; Rigol Olsen, Carolina; Maya Arango, Juan; Morello Casté, Antonio; Piro, Oscar E.; Arán, Vicente J.; Azqueta, Amaia; López de Ceráin, Adela; Monge, Antonio; Rojas, María Antonieta; Yaluff, Gloria (PERGAMON-ELSEVIER SCIENCE LTD, 2006-05-15)
      A series of indazole N-oxide derivatives have been synthesized and their antichagasic and leishmanocidal properties studied. 3-Cyano-2-(4-iodophenyl)-2H-indazole N-1-oxide exhibited interesting antichagasic activity on the ...
    • Initial studies on mechanism of action and cell death of active N-oxide-containing heterocycles in Trypanosoma cruzi epimastigotes in vitro 

      Benítez, Diego; Casanova, Gabriela; Cabrera, Gonzalo; Galanti Garrone, Norbel; Cerecetto, Hugo; González, Mercedes (Cambridge University Press, 2014)
      Chagas disease, endemic in 21 countries across Latin America, kills more people in the region each year than any other parasite-borne disease. Therapeutic options have problems ranging from toxicity, poor efficacy, drug ...
    • New heteroaryl nitrones with spin trap properties: Identification of a 4-furoxanyl derivative with excellent properties to be used in biological systems 

      Barriga, Germán; Olea Azar, Claudio; Norambuena, Ester; Castro, Ana; Porcal, Williams; Gerpe, Alejandra; González, Mercedes; Cerecetto, Hugo (ELSEVIER, 2010)
      A new series of heteroaryl nitrones, 1–7, bearing furoxanyl and thiadiazolyl moieties, were evaluated for their free radical-trapping properties. The physicochemical characterization by electron paramagnetic resonance ...
    • New potent 5-nitroindazole derivatives as inhibitors of Trypanosoma cruzi growth: Synthesis, biological evaluation, and mechanism of action studies 

      Rodríguez Borges, Jorge; Arán, Vicente J.; Boiani, Lucía; Olea Azar, Claudio; Lavaggi, María Laura; González, Mercedes; Cerecetto, Hugo; Diego Maya, Juan; Carrasco Pozo, Catalina; Speisky Cosoy, Hernán (PERGAMON-ELSEVIER SCIENCE LTD, 2009-12-15)
      New 5-nitroindazole derivatives were developed and their antichagasic properties studied. Eight compounds (14-18, 20, 26 and 28) displayed remarkable in vitro activities against Trypanosoma cruzi (T. cruzi). Its unspecific ...
    • New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle 

      Porcal, Williams; Hernández, Paola; Boiani, Lucía; Boiani, Mariana; Ferreira, Ana; Chidichimo, Agustina; Cazzulo, Juan J.; Olea Azar, Claudio; González, Mercedes; Cerecetto, Hugo (Elsevier Ltd, 2008-07)
      Hybrid compounds containing hydrazones and benzofuroxan pharmacophores were designed as potential Trypanosoma cruzi-enzyme inhibitors. The majority of the designed compounds was successfully synthesized and biologically ...
    • Nitrofurylsemicarbazone rhenium and ruthenium complexes as anti-trypanosomal agents 

      Otero, Lucía; Aguirre, Gabriela; Boiani, Lucía; Denicola, Ana; Rigol Olsen, Carolina; Olea Azar, Claudio; Maya Arango, Juan; Morello Casté, Antonio; González, Mercedes; Gambino, Dinorah; Cerecetto, Hugo (ELSEVIER, 2006-11)
      Rhenium and ruthenium complexes of the type [(ReOCl2)-O-V(PPh3)L] and [(RuC2)-C-II(DMSO)(2)L], where L are 5-nitroftitylsemicarbazone derivatives, were prepared in an effort to obtain new anti-trypanosomal agents combining ...
    • Nitrones: a potential new alternative as therapeutic agents 

      Barriga González, Germán Eduardo; Aliaga, Carolina; Olea Azar, Claudio; Zúniga López, María C.; González, Mercedes; Cerecetto, Hugo (Bentham Science Publishers Ltd., 2017)
      Background: Nowadays, nitrones are the most used spin traps to characterize free radicals in biological systems due to the versatility and variety depending on the types of radicals to study and that the half-lives of the ...
    • Novel antitrypanosomal agents based on palladium nitrofurylthiosemicarbazone complexes: DNA and redox metabolism as potential therapeutic targets 

      Otero, Lucía; Vieites, Marisol; Boiani, Lucía; Denicola, Ana; Rigol Olsen, Carolina; Opazo, Lucía; Olea Azar, Claudio; Maya Arango, Juan; Morello Casté, Antonio; Krauth Siegel, R. Luise; Piro, Oscar E.; Castellano, Eduardo; González, Mercedes; Gambino, Dinorah; Cerecetto, Hugo (AMER CHEMICAL SOC, 2006-06-01)
      In the search for new therapeutic tools against American Trypanosomiasis palladium complexes with bioactive nitrofuran-containing thiosemicarbazones as ligands were obtained. Sixteen novel palladium (II) complexes with the ...
    • Novel Benzo[1,2-c]1,2,5-Oxadiazole N-Oxide Derivatives as Antichagasic Agents: Chemical and Biological Studies 

      Olea Azar, Claudio; Rigol Olsen, Carolina; Mendizábal Emaldía, Fernando; Cerecetto, Hugo; Di Maio, R.; González, Mercedes; Porcal, Williams; Morello Casté, Antonio; Repetto Scaramelli, Yolanda; Maya Arango, Juan (BENTHAM SCIENCE PUBL LTD., 2005-06)
      In order to gain inside the mechanism of action of a series of benzo[1,2-c]1,2,5-oxadiazole N-oxide derivatives with in vitro anti-trypanosomal activity, electrochemical and biological studies were performed. Cyclic ...
    • Platinum(II) metal complexes as potential anti-Trypanosoma cruzi agents 

      Vieites, Marisol; Otero, Lucía; Santos, Diego; Toloza, Jeannette; Figueroa, Roberto; Norambuena, Ester; Olea Azar, Claudio; Aguirre, Gabriela; Cerecetto, Hugo; González, Mercedes; Morello Casté, Antonio; Maya Arango, Juan; Garat, Beatriz; Gambino, Dinorah (ELSEVIER SCIENCE INC, 2008-05)
      In the search for new therapeutic tools against Chagas’ disease (American Trypanosomiasis) two series of new platinum(II) complexes with bioactive 5-nitrofuryl containing thiosemicarbazones as ligands were synthesized, ...
    • Platinum-based complexes of bioactive 3-(5-nitrofuryl)acroleine thiosemicarbazones showing anti-Trypanosoma cruzi activity 

      Vieites, Marisol; Otero, Lucía; Santos, Diego; Olea Azar, Claudio; Norambuena, Ester; Aguirre, Gabriela; Cerecetto, Hugo; González, Mercedes; Kemmerling Weis, Ulrike; Morello, Antonio; Maya Arango, Juan; Gambino, Dinorah (2009)
      Eight new platinum(II) complexes with 3-(5-nitrofuryl)acroleine thiosemicarbazones showing anti-trypanosomal activity were synthesized, characterized and in vitro evaluated. Most of the complexes showed IC50 values in the ...
    • Potent 5-nitrofuran derivatives inhibitors of Trypanosoma cruzi growth: Electrochemical, spectroscopic and biological studies 

      Aravena, María C.; Olea Azar, Claudio; Cerecetto, Hugo; González, Mercedes; Maya Arango, Juan; Rodríguez Becerra, Jorge (2011)
      Cyclic voltammetry and electron spin resonance techniques were used in the investigation of several potential antiprotozoal containing thiosemicarbazone and carbamate nitrofurans. In the electrochemical behaviour, a ...
    • Potent in vitro anti-Trypanosoma cruzi activity of pyridine-2-thiol N-oxide metal complexes having an inhibitory effect on parasite-specific fumarate reductase 

      Vieites, Marisol; Smircich, Pablo; Parajón Costa, Beatriz; Rodríguez Borges, Jorge; Galaz, Verónica; Olea Azar, Claudio; Otero, Lucía; Aguirre, Gabriela; Cerecetto, Hugo; González, Mercedes; Gómez Barrio, Alicia; Garat, Beatriz; Gambino, Dinorah (SPRINGER, 2008-06)
      In the search for new therapeutic tools against Chagas disease (American trypanosomiasis) palladium and platinum complexes of the bioactive ligand pyridine-2- thiol N-oxide were exhaustively characterized and evaluated in ...
    • Relationship Between Physicochemical Properties and Herbicidal Activity of 1,2,5-Oxadiazole N-Oxide Derivatives 

      Fernández, Luciana A.; Santo, Marisa R.; Reta, Mario; Giacomelli, Liliana; Cattana, Rosa; Silber, Juana J.; Risso, Mariela; Cerecetto, Hugo; González, Mercedes; Olea Azar, Claudio (MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL, 2005-09)
      The relationship between the herbicidal activity of a number of novel 1,2,5- oxadiazole N-oxides and some physicochemical properties potentially related with this bioactivity, such as polarity, molecular volume, proton ...