Now showing items 1-13 of 13

    • Activation of Cl Channels by Human Chorionic Gonadotropin in Luteinized Granulosa Cells of the Human Ovary Modulates Progesterone Biosynthesis 

      Olivero, Pablo; Leiva Salcedo, Elías; Devoto, Luigi; Stutzin Schottlander, Andrés (ENDOCRINE SOC, 2008-09)
      Chloride permeability pathways and progesterone (P4) secretion elicited by human chorionic gonadotropin (hCG) in human granulosa cells were studied by electrophysiological techniques and single-cell volume, membrane ...
    • Activation of Cl- channels by human chorionic gonadotropin in luteinized granulosa cells of the human ovary modulates progesterone biosynthesis 

      Olivero, Pablo; Leiva Salcedo, Elías; Devoto, Luigi; Stutzin Schottlander, Andrés (2008)
      Chloride permeability pathways and progesterone (P4) secretion elicited by human chorionic gonadotropin (hCG) in human granulosa cells were studied by electrophysiological techniques and single-cell volume, membrane potential ...
    • Casein kinase-mediated phosphorylation of serine 839 is necessary for basolateral localization of the Ca 

      Cerda, Oscar; Cáceres, Mónica; Park, Kang Sik; Leiva-Salcedo, Elías; Romero, Aníbal; Varela, Diego; Trimmer, James S.; Stutzin, Andrés (Springer Verlag, 2015)
      © 2014, Springer-Verlag Berlin Heidelberg. Transient receptor potential melastatin-like 4 (TRPM4) is a Ca<sup>2+</sup>-activated non-selective cation channel expressed in a wide range of human tissues. TRPM4 ...
    • Casein kinase-mediated phosphorylation of serine 839 is necessary for basolateral localization of the Ca2+-activated non-selective cation channel TRPM4 

      Cerda Arancibia, Óscar; Cáceres Lluch, Mónica; Park, Kang-Sik; Leiva Salcedo, Elías; Romero, Aníbal; Varela Lekanda, Diego; Trimmer, James S.; Stutzin Schottlander, Andrés (Springer, 2015)
      Transient receptor potential melastatin-like 4 (TRPM4) is a Ca2+-activated non-selective cation channel expressed in a wide range of human tissues. TRPM4 participates in a variety of physiological processes such as T cell ...
    • Diminished Acute Phase Response and Increased Hepatic Inflammation of Aged Rats in Response to Intraperitoneal Injection of Lipopolysaccharide 

      Gómez, Christian; Acuña Castillo, Claudio; Pérez Núñez, Claudio; Leiva Salcedo, Elías; Riquelme, Denise; Ordenes, Gamaliel; Oshima, Kiyoko; Aravena, Mauricio; Pérez, Viviana I.; Nishimura, Sumiyo; Sabaj Diez, Valeria; Walter, Robin Ann; Sierra, Felipe (GERONTOLOGICAL SOC AMER, 2008-12)
      Aging is associated with a deterioration of the acute phase response to inflammatory challenges. However, the nature of these defects remains poorly defined. We analyzed the hepatic inflammatory response after intraperitoneal ...
    • Hydrogen peroxide removes TRPM4 current desensitization conferring increased vulnerability to necrotic cell death 

      Simon, Felipe; Leiva Salcedo, Elías; Armisen Yáñez, Ricardo; Riveros, Ana; Cerda, Oscar; Varela, Diego; Eguiguren, Ana Luisa; Olivero, Pablo; Stutzin Schottlander, Andrés (2010)
      Necrosis is associated with an increase in plasma membrane permeability, cell swelling, and loss of membrane integrity with subsequent release of cytoplasmic constituents. Severe redox imbalance by overproduction of reactive ...
    • Lipopolysaccharide inhibits the channel activity of the P2X7 receptor 

      Leiva Salcedo, Elías; Coddou, Claudio; Rodríguez, Felipe E.; Penna, Antonello; López, Ximena; Neira, Tanya; Fernández, Ricardo; Imarai, Mnica; Rios, Miguel; Escobar, Jorge; Montoya, Margarita; Huidobro Toro, Juan Pablo; Escobar, Alejandro; Acuña Castillo, Claudio (2011)
      The purinergic P2X7 receptor (P2X7R) plays an important role during the immune response, participating in several events such as cytokine release, apoptosis, and necrosis. The bacterial endotoxin lipopolysaccharide (LPS) ...
    • P2X4 Activation Modulates Volume-sensitive Outwardly Rectifying Chloride Channels in Rat Hepatoma Cells 

      Varela Lekanda, Diego; Penna, Antonello; Simon, Felipe; Eguiguren Ossa, Ana; Leiva Salcedo, Elías; Cerda, Oscar; Sala, Francisco; Stutzin Schottlander, Andrés (2010-03-05)
      Volume-sensitive outwardly rectifying (VSOR) Cl channels are critical for the regulatory volume decrease (RVD) response triggered upon cell swelling. Recent evidence indicates that H2O2 plays an essential role in the ...
    • Subcellular Localization and Activity of TRPM4 in Medial Prefrontal Cortex Layer 2/3 

      Riquelme, Denise; Silva, Ian; Philp, Ashleigh M.; Huidobro Toro, Juan Pablo; Cerda, Oscar; Trimmer, James; Leiva Salcedo, Elías (Frontiers Media SA, 2018)
      TRPM4 is a Ca2+-activated non-selective cationic channel that conducts monovalent cations. TRPM4 has been proposed to contribute to burst firing and sustained activity in several brain regions, however, the cellular and ...
    • T-kininogen can either induce or inhibit proliferation in Balb/c 3T3 fibroblasts, depending on the route of administration 

      Aravena, Mauricio; Pérez, C.; Pérez, V.; Acuña Castillo, Claudio; Gómez, Christian; Leiva Salcedo, Elías; Nishimura, Sumiyo; Sabaj, B.; Walter, Robin Ann (ELSEVIER SCI IRELAND LTD, 2005-03)
      T-kininogen (T-KG) is a precursor of T-kinin, the most abundant kinin in rat serum, and also acts as a strong and specific cysteine proteinase inhibitor. Its expression is strongly induced during aging in rats, and expression ...
    • T-kininogen induces endothelial cell proliferation 

      Pérez, Viviana; Leiva Salcedo, Elías; Acuña Castillo, Claudio; Aravena, Mauricio; Gómez, Christian; Sabaj Diez, Valeria; Colombo, Alicia; Nishimura, Sumiyo; Pérez Núñez, Claudio; Walter, Robin Ann; Sierra, Felipe (ELSEVIER, 2006-03)
      Basal proliferation of endothelial cells increases with age, and this might play a role in the etiology of age-related vascular diseases, as well as angiogenesis. Serum kininogen levels increase during aging in rats and ...
    • T-kininogen, a cystatin-like molecule, inhibits ERK-dependent lymphocyte proliferation 

      Acuña Castillo, Claudio; Aravena, Mauricio; Leiva Salcedo, Elías; Pérez, Viviana; Gómez, Christian; Sabaj Diez, Valeria; Nishimura, Sumiyo; Pérez Núñez, Claudio; Colombo, Alicia; Walter, Robin Ann; Sierra, Felipe (ELSEVIER, 2005-12)
      Plasma levels of kininogens increase with age in both rats and humans. Kininogens are inhibitors of cysteine proteinases, and filarial cysteine proteinase inhibitors (cystatins) reduce the proliferation of T cells. We ...
    • TRPM4 Is a Novel Component of the Adhesome Required for Focal Adhesion Disassembly, Migration and Contractility 

      Cáceres Lluch, Mónica; Ortiz, Liliana; Recabarren, Tatiana; Romero, Aníbal; Colombo Flores, Alicia; Leiva Salcedo, Elías; Varela Lekanda, Diego; Rivas, José; Silva, Ian; Morales, Diego; Campusano, Camilo; Almarza, Óscar; Simon, Felipe; Toledo Araya, Héctor; Park, Kang-Sik; Trimmer, James S.; Cerda, Óscar (Public Library Science, 2015)
      Cellular migration and contractility are fundamental processes that are regulated by a variety of concerted mechanisms such as cytoskeleton rearrangements, focal adhesion turnover, and Ca2+ oscillations. TRPM4 is a ...