Now showing items 1-8 of 8

    • Acuña Castillo, Claudio; Scorza, Cecilia; Reyes Parada, Miguel; Cassels Niven, Bruce; Huidobro Toro, Juan Pablo (Elsevier Science Inc., 2000-06-06)
      To assess the pharmacodynamic profile of ALEPH-2, a phenylisopropylamine derivative with alleged anxiolytic and hallucinogenic properties, Xenopus laevis oocytes were microinjected with either of the rat cRNA for the ...
    • Donoso, M. V.; Carvajal, A.; Paredes Vargas, Alfonso; Tomic, A.; Koenig, Cecilia S.; Huidobro Toro, Juan Pablo (ELSEVIER SCIENCE INC, 2002-09)
      Neuropeptide Y (NPY) and noradrenaline (NA) are co-transmitters at many sympathetic synapses, but it is not yet clear if their release is independently regulated. To address this question, we quantified the electrically ...
    • Robles Planells, Claudia; Barrera Ávalos, Carlos; Rojo, Leonel E.; Spencer, Eugenio; Cortez San Martín, Eugenio; Matiacevich, Silvia; Pavez, Jorge; Milla, Luis A.; Navarro, Franco D.; Martínez, Brandon A; Bravo, Francisco J.; Mella, Andrea; Huidobro Toro, Juan Pablo; Fernández, Ricardo; Escobar Álvarez, Alejandro; Acuña Castillo, Claudio (Hindawi, 2020)
      Reovirus is known to have an anticancer effect in both the preclinical and clinical assays. Current evidence suggests that the reovirus-mediated impact on tumor growth depends on the activation of specific antitumor immune ...
    • Robles Planells, Claudia; Sánchez-Guerrero, Giselle; Barrera Ávalos, Carlos; Matiacevich, Silvia; Rojo, Leonel E.; Pavéz, Jorge; Salas Huenuleo, Edison; Kogan, Marcelo J.; Escobar Álvarez, Alejandro; Milla, Luis A.; Fernández, Ricardo; Imarai, Mónica; Spencer, Eugenio; Huidobro Toro, Juan Pablo; Acuña Castillo, Claudio (Hindawi, 2020)
      Oncolytic virus therapy has been tested against cancer in preclinical models and clinical assays. Current evidence shows that viruses induce cytopathic effects associated with fusogenic protein-mediated syncytium formation ...
    • Acuña Castillo, Claudio; Villalobos, Claudio; Moya, Pablo R.; Sáez, Patricio; Cassels Niven, Bruce; Huidobro Toro, Juan Pablo (Nature Publishing Group, 2002-04-04)
      1 The pharmacological pro®le of a series of (+)-2,5-dimethoxy-4-(X)-phenylisopropylamines (X=I, Br, NO2, CH3, or H) and corresponding phenylethylamines, was determined in Xenopus laevis oocytes injected with cRNA coding ...
    • Boric, M. P.; Figueroa, X. F.; Donoso, M. V.; Paredes Vargas, Alfonso; Poblete, I.; Huidobro Toro, Juan Pablo (AMER PHYSIOLOGICAL SOC, 1999-09)
      To evaluate whether sympathetic activity induces nitric oxide (NO) production, we perfused the rat arterial mesenteric bed and measured luminally accessible norepinephrine (NE), NO, and cGMP before, during, and after ...
    • Ferrada, Evandro; Arancibia, Verónica; Loeb, Bárbara; Norambuena, Ester; Olea Azar, Claudio; Huidobro Toro, Juan Pablo (ELSEVIER SCIENCE BV, 2007-05)
      Successful trials with 5-chloro-7-iodo-8-hydroxyquinoline (clioquinol, CQ) for Alzheimer’s disease treatment prompted renewed interest in assessing whether its therapeutic action is related to the coordination of ...
    • Riquelme, Denise; Silva, Ian; Philp, Ashleigh M.; Huidobro Toro, Juan Pablo; Cerda, Oscar; Trimmer, James; Leiva Salcedo, Elías (Frontiers Media SA, 2018)
      TRPM4 is a Ca2+-activated non-selective cationic channel that conducts monovalent cations. TRPM4 has been proposed to contribute to burst firing and sustained activity in several brain regions, however, the cellular and ...