Now showing items 1-6 of 6

    • A novel caveolin-1/p85α/Rab5/Tiam1/Rac1 signaling axis in tumor cell migration and invasion 

      Díaz, Jorge; Mendoza, Pablo; Silva, Patricio; Quest, Andrew F. G.; Torres, Vicente A. (Landes Bioscience, 2014)
      © Jorge Díaz, Pablo endoza, Patricio Silva, Andrew FG Quest, and Vicente A Torres. The small GTPase Rab5 has been frequently studied in the context of intracellular trafficking, but evidence obtained more recently has ...
    • Caveolin-1: An ambiguous partner in cell signalling and cancer 

      Quest, Andrew F. G.; Gutiérrez Pajares, Jorge L.; Torres, Vicente A. (2008)
      Caveolae are small plasma membrane invaginations that have been implicated in a variety of functions including transcytosis, potocytosis and cholesterol transport and signal transduction. The major protein component of ...
    • Rab5 is required in metastatic cancer cells for caveolin-1-enhanced Rac1 activation, migration and invasion 

      Díaz, Jorge; Mendoza, Pablo; Ortiz, Rina; Díaz, Natalia; Leyton Campos, Lisette; Stupack, Dwayne; Quest, Andrew F. G.; Torres, Vicente A. (Company of Biologists Ltd, 2014)
      Rab5 is a small GTPase that regulates early endosome trafficking and other cellular processes, including cell adhesion and migration. Specifically, Rab5 promotes Rac1 activation and cancer cell migration, but little is ...
    • Role of glycosylation in hypoxia-driven cell migration and invasion 

      Arriagada, Cecilia; Silva, Patricio; Torres, Vicente A. (NLM (Medline), 2019)
      Hypoxia, a common condition of the tumor microenvironment, induces changes in the proteome of cancer cells, mainly via HIF-1, a transcription factor conformed by a constitutively expressed β-subunit and an oxygen-regulated ...
    • The Netrin-4/Laminin γ1/Neogenin-1 complex mediates migration in SK-N-SH neuroblastoma cells 

      Villanueva, Andrea A.; Puvogel, Sofía; Lois, Pablo; Muñoz-Palma, Ernesto; Ramírez Orellana, Manuel; Lubieniecki, Fabiana; Casco Claro, Fernando; Gallegos, Iván; García-Castro, Javier; Sanchez-Gomez, Pilar; Torres, Vicente A.; Palma, Verónica (Taylor and Francis Inc., 2018)
      © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group. Neuroblastoma (NB) is the most common pediatric extracranial solid tumor. It arises during development of the sympathetic nervous system. Netrin-4 (NTN4), ...
    • The Netrin-4/Neogenin-1 axis promotes neuroblastoma cell survival and migration 

      Villanueva, Andrea A.; Falcón, Paulina; Espinoza, Natalie; Solano, R. Luis; Milla, Luis A.; Hernandez-SanMiguel, Esther; Torres, Vicente A.; Sanchez-Gomez, Pilar; Palma, Verónica (Impact Journals LLC, 2017)
      Neogenin-1 (NEO1) is a transmembrane receptor involved in axonal guidance, angiogenesis, neuronal cell migration and cell death, during both embryonic development and adult homeostasis. It has been described as a dependence ...