Browsing by Author "95bc464d-a688-4a28-bcf0-839034cbfb79"
Now showing items 1-20 of 39
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Pérez, Hernán; Soto Moyano, Rubén; Ruiz, Samuel; Hernández, Alejandro; Sierralta, Walter; Olivares, Ricardo; Núñez, Héctor; Flores, Osvaldo; Morgan, Carlos; López Valladares, Luis; Gatica, Arnaldo; Flores, Francisco J. (2010)Prenatal undernutrition induces hypertension later in life, possibly by disturbing the hypothalamo-pituitary-adrenal axis through programming decreased expression of hypothalamic glucocorticoid receptors. We examined the ...
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Pelissier Serrano, Teresa; Paeile, Carlos; Soto Moyano, Rubén; Saavedra, Hernán; Hernández, Alejandro (1990)The antinociceptive activity of the selective k opioid agonist U-50,488H, given intrathecally (i.t.) against chemically induced cutaneous pain in rats, was assessed from cumulative dose-response experiments and the formalin ...
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Alvarez, Pedro; Brun, Aurore; Labertrandie, Anaïs; Lopez, José; Correa, Alejandro; Constandil, Luís; Hernández, Alejandro; Pelissier Serrano, Teresa (Quintessence Publishing Co. Inc., 2011)AIMS: To develop a behavioral model in mice that is capable of mimicking some distinctive symptoms of human posttraumatic trigeminal neuropathic pain such as spontaneous pain, cold allodynia, and chemical÷inflammatory ...
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Cazanga, Victoria; Hernández, Alejandro; Morales, Bernardo; Pelissier Serrano, Teresa; Constandil, Luis (Quintessence Publishing Co. Inc., 2018)© Quintessenz. Aims: To evaluate in mice the antinociceptive effect of copper in spinal and trigeminal nociceptive pathways by using the intraplantar and orofacial formalin tests, respectively, and to examine whether this ...
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Pelissier Serrano, Teresa; Infante, Claudio; Constandil, Luis; Espinosa, Jeannette; Lapeyra, Carolina De; Hernández, Alejandro (2008)We assessed whether intrathecal administration of the uncompetitive and competitive NMDA receptor antagonists ketamine and (±)CPP, respectively, could produce differential modulation on chemical and mechanical nociception ...
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Pelissier Serrano, Teresa; Hernández, Alejandro; Mestre, Christine; Eschalier, Alain; Laurido, Claudio; Paeile, Carlos; Alvarez, Pedro; Soto Moyano, Rubén (2001)The antinociceptive effect of clomipramine was studied in monoarthritic rats by using the paw pressure test and the C-fiber-evoked reflex. Monoarthritis was produced by intra-articular injection of complete Freund's adjuvant ...
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Morales, Francisco; Constandil, Luis; Pelissier Serrano, Teresa; Hernández, Alejandro; Laurido, Claudio (2012)Introduction: Multiple studies have shown that glial cells of the spinal cord, such as astrocytes and microglia, have close contact with neurons, suggesting the term tripartite synapse. In these synapses, astrocytes ...
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Sáez Briones, Patricio; Castro Castillo, Vicente; Díaz Véliz, Gabriela; Valladares Boasi, Luis; Barra, Rafael; Hernández, Alejandro; Cassels Niven, Bruce (Frontiers Media S.A., 2019)The entactogen MDMA (3,4-methylenedioxy-methamphetamine, “Ecstasy”) exerts its psychotropic effects acting primarily as a substrate of the serotonin transporter (SERT) to induce a non-exocytotic release of serotonin. ...
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Pelissier Serrano, Teresa; Laurido, Claudio; Hernández, Alejandro; Constandil, Luis; Eschalier, Alain (2006)Studies on the effect of dopaminergic agonists in behavioral measures of nociception have gathered numerous but rather conflicting data. We studied the effects of the D1/D2 receptor agonist apomorphine, as well as the ...
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Retamal, Jeffri; Reyes, Andrea; Ramirez, Paulina; Nogues Bravo, David; Hernández, Alejandro; Pelissier Serrano, Teresa; Villanueva, Luis; Constandil, Luis (Frontiers Media S.A., 2018)© 2007 - 2018 Frontiers Media S.A. All Rights Reserved. Intrathecal administration of brain derived neurotrophic factor (BDNF) induces long-term potentiation (LTP) and generates long-lasting central sensitization in spinal ...
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Laurido, Claudio; Hernández, Alejandro; Pérez, Hernán (1996)Development of tolerance and cross-tolerance after acute administration of the μ agonist morphine and the K agonist U-50,488H was assessed in rats, through recording of a C-fiber-evoked spinal nociceptive reflex. Rats ...
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Soto Moyano, Rubén; Hernández, Alejandro; Ruiz, Samuel; Pérez, Hernán; Paeile, Carlos (1978)The influence of pentazocine on primary cortical evoked potentials was studied in guinea pig under pentobarbital anesthesia. Pentazocine (10 mg/kg, i.v.) increased the latency time of evoked responses to posterior limb ...
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Burgos, Héctor; Hernández, Alejandro; Constandil, Luis; Ríos, Miguel; Flores, Osvaldo; Puentes, Gustavo; Hernández, Karina; Morgan, Carlos; Valladares Boasi, Luis; Castillo, Amparo; Cofre, Christian; Milla, Luis A.; Sáez-Briones, Patricio; Barra, Rafael (Elsevier B.V., 2019)Moderate reduction of dietary protein (from 25% to 8% casein) in pregnant rats, calorically compensated by carbohydrates, gives rise to ‘hidden prenatal malnutrition’ (HPM) in the offspring since it does not alter body and ...
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Pérez, Hernán; Ruíz, Samuel; Hernández, Alejandro; Soto Moyano, Rubén (1983)Cortical reactivity of parietal association area was studied in normal and undernourished rats. (i) The normal group was from mothers which were fed a 21.5% protein diet during lactation. (ii) The undernourished group was ...
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Constandil, Luis; Hernández, Alejandro; Pelissier Serrano, Teresa; Arriagada, Osvaldo; Espinoza, Karla; Burgos, Hector; Laurido, Claudio (2009)Introduction: Cytokines produced by spinal cord glia after peripheral injuries have a relevant role in the maintenance of pain states. Thus, while IL-1β is overexpressed in the spinal cords of animals submitted to experimental ...
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Laurido, Claudio; Pelissier Serrano, Teresa; Pérez, Hernán; Flores, Francisco; Hernández, Alejandro (Lippincott Williams and Wilkins, 2001)The effects of systemically and intrathecally administered ketamine on spinal wind-up of normal and monoarthritic rats were studied by using C-fiber reflex responses evoked by repetitive (0.6Hz) electric stimulation. Both ...
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Laurido, Claudio; Pelissier Serrano, Teresa; Soto Moyano, Rubén; López Valladares, Luis; Flores, Francisco; Hernández, Alejandro (Lippincott Williams and Wilkins, 2002)Melatonin has been shown to exert potent antinociception but the sites and mechanisms of action underlying this effect have not yet been clarified. The effect of melatonin on spinal cord nociceptive transmission was studied ...
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Hernández, Alejandro; Neira, Susana; Soto Moyano, Rubén (1985)The somatosensory cortex responses and periaqueductal grey matter responses evoked by electric peripheral nerve stimulation were studied following topical application of 1% morphine solution to the primary somatosensory ...
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Hernández, Alejandro; Burgos, Héctor; Mondaca, Mauricio; Barra, Rafael; Núñez, Héctor; Pérez, Hernán; Soto Moyano, Rubén; Sierralta, Walter; Fernández, Victor; Olivares, Ricardo; López Valladares, Luis (Hindawi Publishing Corporation, 2008)Reduction of the protein content from 25 to 8% casein in the diet of pregnant rats results in impaired neocortical long-term potentiation (LTP) of the offspring together with lower visuospatial memory performance. The ...
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Arriagada, Osvaldo; Constandil, Luis; Hernández, Alejandro; Barra, Rafael; Soto Moyano, Rubén; Laurido, Claudio (2007)To investigate the contribution of glial cells in the spinal cord nociceptive transmission, the effect of intrathecally administered interleukin-1β (IL-1β) was studied in rats treated with the glial cell inactivator ...