Now showing items 1-5 of 5

    • A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway 

      Zamorano, Sebastián; Rojas Rivera, Diego; Lisbona, Fernanda; Parra, Valentina; Court, Felipe A.; Villegas, Rosario; Cheng, Emily H.; Korsmeyer, Stanley J.; Lavandero González, Sergio; Hetz Flores, Claudio (2012)
      Most intrinsic death signals converge into the activation of pro-apoptotic BCL-2 family members BAX and BAK at the mitochondria, resulting in the release of cytochrome c and apoptosome activation. Chronic endoplasmic ...
    • Dynamics of degeneration and regeneration in developing zebrafish peripheral axons reveals a requirement for extrinsic cell types 

      Villegas, Rosario; Martin, Seanna M.; O'Donnell, Kelley C.; Carrillo, Simon A.; Sagasti, Alvaro; Allende Connelly, Miguel (2012)
      Background: Understanding the cellular mechanisms regulating axon degeneration and regeneration is crucial for developing treatments for nerve injury and neurodegenerative disease. In neurons, axon degeneration is distinct ...
    • Expression profiling identifies novel Hh/Gli-regulated genes in developing zebrafish embryos 

      Bergeron, Sadie A.; Milla, Luis A.; Villegas, Rosario; Shen, Meng-Chieh; Burgess, Shawn M.; Allende Connelly, Miguel; Karlstrom, Rolf O.; Palma Alvarado, Verónica (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2007-12-11)
      The Hedgehog (Hh) signaling pathway plays critical instructional roles during embryonic development. Misregulation of Hh/Gli signaling is a major causative factor in human congenital disorders and in a variety of cancers. ...
    • Expression profiling identifies novel Hh/Gli-regulated genes in developing zebrafish embryos 

      Bergeron, Sadie A.; Milla, Luis A.; Villegas, Rosario; Shen, Meng Chieh; Burgess, Shawn M.; Allende Connelly, Miguel; Karlstrom, Rolf O.; Palma, Verónica (2008)
      The Hedgehog (Hh) signaling pathway plays critical instructional roles during embryonic development. Misregulation of Hh/Gli signaling is a major causative factor in human congenital disorders and in a variety of cancers. ...
    • Lef1-dependent Wnt/β-catenin signalling drives the proliferative engine that maintains tissue homeostasis during lateral line development 

      Valdivia, Leonardo E.; Young, Rodrigo M.; Hawkins, Thomas A.; Stickney, Heather L.; Cavodeassi, Florencia; Schwarz, Quenten; Pullin, Lisa M.; Villegas, Rosario; Moro, Enrico; Argenton, Francesco; Allende Connelly, Miguel; Wilson, Stephen W. (2011)
      During tissue morphogenesis and differentiation, cells must self-renew while contemporaneously generating daughters that contribute to the growing tissue. How tissues achieve this precise balance between proliferation and ...