Browsing by Author "9cacedf0-caa2-49e2-8e2b-d046d32e7f07"

Now showing items 1-11 of 11

    • A failure in energy metabolism and antioxidant uptake precede symptoms of Huntington's disease in mice 
      Acuña, Aníbal I.; Esparza, Magdalena; Kramm, Carlos; Beltrán, Felipe A.; Parra, Alejandra V.; Cepeda, Carlos; Toro, Carlos A.; Vidal, René L.; Hetz Flores, Claudio; Concha, Ilona I.; Brauchi, Sebastián; Levine, Michael S.; Castro, Maite A. (Nature Publishing Group, 2013)
      Huntington's disease has been associated with a failure in energy metabolism and oxidative damage. Ascorbic acid is a powerful antioxidant highly concentrated in the brain where it acts as a messenger, modulating neuronal ...
    • Cellular and subcellular localization of Marlin-1 in the brain 
      Vidal, René L.; Valenzuela, José I.; Luján, Rafael; Couve Correa, Andrés (2009)
      Background: Marlin-1 is a microtubule binding protein that associates specifically with the GABAB1 subunit in neurons and with members of the Janus kinase family in lymphoid cells. In addition, it binds the molecular motor ...
    • Dendritic assembly of heteromeric γ-aminobutyric acid type B receptor subunits in hippocampal neurons 
      Ramírez, Omar A.; Vidal, René L.; Tello, Judith A.; Vargas, Karina J.; Kindler, Stefan; Härtel, Steffen; Couve, Andrés (2009)
      Understanding the mechanisms that control synaptic efficacy through the availability of neurotransmitter receptors depends on uncovering their specific intracellular trafficking routes. γ-Aminobutyric acid type B (GABAB) ...
    • ER chaperones in neurodegenerative disease: Folding and beyond 
      García Huerta, Paula; Bargsted, Leslie; Rivas, Alexis; Matus, Soledad; Vidal, René L. (Elsevier, 2016)
      Proteins along the secretory pathway are co-translationally translocated into the lumen of the endoplasmic reticulum (ER) as unfolded polypeptide chains. Afterwards, they are usually modified with N-linked glycans, correctly ...
    • Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal ... 
      García Huerta, Paula; Troncoso Escudero, Paulina; Wu, Di; Thiruvalluvan, Arun; Cisternas, Marisol; Henríquez, Daniel R.; Plate, Lars; Chana-Cuevas, Pedro; Saquel, Cristian; Thielen, Peter; Longo, Kenneth A.; Geddes, Brad J.; Lederkremer, Gerardo Z.; Sharma, Neeraj; Shenkman, Marina; Naphade, Swati; Sardi, S. Pablo; Spichiger, Carlos; Richter, Hans G.; Court, Felipe A.; Tshilenge, Kizito Tshitoko; Ellerby, Lisa M.; Wiseman, R. Luke; Gonzalez Billault, Christian; Bergink, Steven; Vidal, René L.; Hetz Flores, Claudio (Springer, 2020)
      Impaired neuronal proteostasis is a salient feature of many neurodegenerative diseases, highlighting alterations in the function of the endoplasmic reticulum (ER). We previously reported that targeting the transcription ...
    • IRE1 alpha governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A 
      Urra, Hery; Henríquez, Daniel R.; Cánovas, José; Villarroel Campos, David; Carreras Sureda, Amado; Pulgar, Eduardo; Molina, Emiliano; Hazari, Younis M.; Limia, Celia M.; Álvarez Rojas, Sebastián; Figueroa, Ricardo; Vidal, René L.; Rodríguez, Diego A.; Rivera, Claudia A.; Court, Felipe A.; Couve Correa, Andrés; Qi, Ling; Chevet, Eric; Akai, Ryoko; Iwawaki, Takao; Concha, Miguel L.; Glavic Maurer, Álvaro; González Billault, Christian; Hetz Flores, Claudio (Nature, 2018)
      Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a signalling network known as the unfolded protein response (UPR). Here, we identified filamin A as a major binding partner of the ER stress transducer ...
    • Marlin-1 and conventional kinesin link GABAB receptors to the cytoskeleton and regulate receptor transport 
      Vidal, René L.; Ramírez, Omar A.; Sandoval, Lisette; Koenig Robert, Roger; Härtel, Steffen; Couve Correa, Andrés (2007)
      The cytoskeleton and cytoskeletal motors play a fundamental role in neurotransmitter receptor trafficking, but proteins that link GABAB receptors (GABABRs) to the cytoskeleton have not been described. We recently identified ...
    • Marlin-1 is expressed in testis and associates to the cytoskeleton and GABAB receptors 
      Vidal, René L.; Ramírez, Alfredo; Castro, Maite; Concha, Ilona I.; Couve, Andrés (2008)
      Marlin-1 is a GABAB receptor and Jak tyrosine kinase-binding protein that also associates with RNA and microtubules. In humans and rodents, expression of Marlin-1 is predominantly restricted to the brain, but expression ...
    • RNA interference of Marlin-1/Jakmip1 results in abnormal morphogenesis and migration of cortical pyramidal neurons 
      Vidal, René L.; Fuentes, Patricio; Valenzuela, José Ignacio; Alvarado Díaz, Carlos Patricio; Ramírez, Omar A.; Kukuljan Padilla, Manuel; Couve Correa, Andrés (2012)
      The formation of the nervous systems requires processes that coordinate proliferation, differentiation and migration of neuronal cells, which extend axons, generate dendritic branching and establish synaptic connections ...
    • Targeting autophagy in neurodegenerative diseases 
      Vidal, René L.; Matus, Soledad; Bargsted, Leslie; Hetz Flores, Claudio (Elsevier Ltd, 2014)
      © 2014 Elsevier B.V. All rights reserved. The most prevalent neurodegenerative disorders involve protein misfolding and the aggregation of specific proteins. Autophagy is becoming an attractive target to treat neurodegenerative ...
    • The intersection between growth factors, autophagy and ER stress: A new target to treat neurodegenerative diseases? 
      García Huerta, Paula; Troncoso Escudero, Paulina; Jerez, Carolina; Hetz Flores, Claudio; Vidal, René L. (Elsevier Science, 2016-10-15)
      One of the salient features of most neurodegenerative diseases is the aggregation of specific proteins in the brain. This proteostasis imbalance is proposed as a key event triggering the neurodegenerative cascade. The ...