Now showing items 1-20 of 171

    • A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway 

      Zamorano, Sebastián; Rojas Rivera, Diego; Lisbona, Fernanda; Parra, Valentina; Court, Felipe A.; Villegas, Rosario; Cheng, Emily H.; Korsmeyer, Stanley J.; Lavandero González, Sergio; Hetz Flores, Claudio (2012)
      Most intrinsic death signals converge into the activation of pro-apoptotic BCL-2 family members BAX and BAK at the mitochondria, resulting in the release of cytochrome c and apoptosome activation. Chronic endoplasmic ...
    • A decay of the adaptive capacity of the unfolded protein response exacerbates Alzheimer's disease 

      Gerakis, Yannis; Hetz Flores, Claudio (Elsevier, 2018)
      Alterations in the buffering capacity of the proteostasis network are a salient feature of Alzheimer's disease, associated with the occurrence of chronic endoplasmic reticulum (ER) stress. To cope with ER stress, cells ...
    • A failure in energy metabolism and antioxidant uptake precede symptoms of Huntington's disease in mice 

      Acuña, Aníbal I.; Esparza, Magdalena; Kramm, Carlos; Beltrán, Felipe A.; Parra, Alejandra V.; Cepeda, Carlos; Toro, Carlos A.; Vidal, René L.; Hetz Flores, Claudio; Concha, Ilona I.; Brauchi, Sebastián; Levine, Michael S.; Castro, Maite A. (Nature Publishing Group, 2013)
      Huntington's disease has been associated with a failure in energy metabolism and oxidative damage. Ascorbic acid is a powerful antioxidant highly concentrated in the brain where it acts as a messenger, modulating neuronal ...
    • A molecular reporter for monitoring autophagic flux in nervous system in vivo 

      Castillo, K.; Valenzuela, V.; Oñate, M.; Hetz Flores, Claudio (Elsevier, 2017)
      The relevance of autophagy in neuronal health has been extensively reported in a plethora of conditions affecting the nervous system, such as neurodegenerative diseases, cancer, diabetes, and tissue injury, where altered ...
    • A new method to measure autophagy flux in the nervous system 

      Matus, Soledad; Valenzuela, Vicente; Hetz Flores, Claudio (Taylor and Francis Inc., 2014)
      A current need in the neuroscience field is a simple method to monitor autophagic activity in vivo in neurons. Until very recently, most reports have been based on correlative and static determinations of the expression ...
    • A new model to study cell-to-cell transfer of αSynuclein in vivo 

      Mercado, Gabriela; López, Nélida; Martínez, Alexis; Sardi, Sergio P.; Hetz Flores, Claudio (Elsevier B.V., 2018)
      © 2018 Elsevier Inc. Parkinson's disease (PD) compromises motor control due to the loss of dopaminergic neurons in the substantia nigra pars compacta. At the histopathological level, PD is characterized by the accumulation ...
    • A Novel ER Stress-Independent Function of the UPR in Angiogenesis 

      Urra, Hery; Hetz Flores, Claudio (Cell Press, 2014)
      Tumors rely on the unfolded protein response (UPR) and angiogenesis to survive the metabolic stress of hypoxia. Karali et al. (2014) revealed that VEGF signaling engages UPR sensors in an unconventional manner that is ...
    • AAV-mediated delivery of the transcription factor XBP1s into the striatum reduces mutant Huntingtin aggregation in a mouse model of Huntington's disease 

      Zuleta, Amparo; Vidal, Rene L.; Armentano, Donna; Parsons, Geoffrey; Hetz Flores, Claudio (2012)
      Huntington's disease (HD) is caused by mutations that expand a polyglutamine region in the amino-terminal domain of Huntingtin (Htt), leading to the accumulation of intracellular inclusions and progressive neurodegeneration. ...
    • Activation of the unfolded protein response enhances motor recovery after spinal cord injury 

      Valenzuela, V.; Collyer, E.; Armentano, D.; Parsons, G. B.; Court, F. A.; Hetz Flores, Claudio (NATURE PUBLISHING GROUP, 2012-02)
      Spinal cord injury (SCI) is a major cause of paralysis, and involves multiple cellular and tissular responses including demyelination, inflammation, cell death and axonal degeneration. Recent evidence suggests that ...
    • Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injury 

      Oñate, Martiza; Catenaccio, Alejandra; Martínez, Gabriela; Armentano, Donna; Parsons, Geoffrey; Kerr, Bredford; Hetz Flores, Claudio; Court, Felipe (Nature Publishing Group, 2016)
      Although protein-folding stress at the endoplasmic reticulum (ER) is emerging as a driver of neuronal dysfunction in models of spinal cord injury and neurodegeneration, the contribution of this pathway to peripheral nerve ...
    • Acute pannexin 1 blockade mitigates early synaptic plasticity defects in a mouse model of Alzheimer's disease 

      Flores Muñoz, Carolina; Gómez, Bárbara; Mery, Elena; Mujica, Paula; Gajardo, Ivana; Córdova, Claudio; López Espíndola, Daniela; Durán Aniotz, Claudia; Hetz Flores, Claudio; Muñoz, Pablo; González Jamett, Arlek; Ardiles, Álvaro (Frontiers Media, 2020)
      Synaptic loss induced by soluble oligomeric forms of the amyloid beta peptide (sA beta os) is one of the earliest events in Alzheimer's disease (AD) and is thought to be the major cause of the cognitive deficits. These ...
    • Adaptive preconditioning in neurological diseases - therapeutic insights from proteostatic perturbations 

      Mollereau, B.; Rzechorzek, N. M.; Roussel, B. D.; Sedru, M.; Van den Brink, D. M.; Bailly-Maitre, Beatrice; Palladino, F.; Medinas Bilches, Danilo; Domingos, P. M.; Hunot, S.; Chandran, S.; Birman, S.; Baron, T.; Vivien, D.; Duarte, C. D.; Ryoo, H. D.; Steller, H.; Urano, F.; Chevet, E.; Kroemer, G.; Ciechanover, A.; Calabrese, E. J.; Kaufman, R. J.; Hetz Flores, Claudio (Elsevier, 2016)
      In neurological disorders, both acute and chronic neural stress can disrupt cellular proteostasis, resulting in the generation of pathological protein. However in most cases, neurons adapt to these proteostatic perturbations ...
    • Addicted to secrete - novel concepts and targets in cancer therapy 

      Dejeans, Nicolas; Manié, Serge; Hetz Flores, Claudio; Bard, Frédéric; Hupp, Ted; Agostinis, Patrizia; Samali, Afshin; Chevet, Eric (Elsevier Ltd, 2014)
      The unfolded protein response (UPR) mediates the adaptation of the secretory pathway (SP) to fluctuations in cellular protein demand or to environmental variations. Recently, drug screenings have confirmed the therapeutic ...
    • ALS-linked protein disulfide isomerase variants cause motor dysfunction 

      Woehlbier, Ute; Colombo Flores, Alicia; Saaranen, Mirva J.; Pérez, Viviana; Ojeda, Jorge; Bustos, Fernando J.; Andreu, Catherine; Torres, Mauricio; Valenzuela, Vicente; Medinas Bilches, Danilo; Rozas, Pablo; Vidal, René L.; López González, Rodrigo; Salameh, Johnny; Fernández Collemann, Sara; Muñoz, Natalia; Matus, Soledad; Armisen Yáñez, Ricardo; Sagredo, Alfredo; Palma, Karina; Irrázabal, Thergiory; Almeida, Sandra; González Pérez, Paloma; Campero, Mario; Gao, Fen-Biao; Henny, Pablo; Van Zundert, Brigitte; Ruddock, Lloyd W.; Concha, Miguel L.; Henríquez, Juan P.; Brown, Robert H.; Hetz Flores, Claudio (Wiley-Blackwell, 2016)
      Disturbance of endoplasmic reticulum (ER) proteostasis is a common feature of amyotrophic lateral sclerosis (ALS). Protein disulfide isomerases (PDIs) are ER foldases identified as possible ALS biomarkers, as well as ...
    • Altered prion protein expression pattern in CSF as a biomarker for creutzfeldt-jakob disease 

      Torres, Mauricio; Cartier Rovirosa, Luis; Matamala, José Manuel; Hernández, Nancy; Woehlbier, Ute; Hetz Flores, Claudio (2012)
      Creutzfeldt-Jakob disease (CJD) is the most frequent human Prion-related disorder (PrD). The detection of 14-3-3 protein in the cerebrospinal fluid (CSF) is used as a molecular diagnostic criterion for patients clinically ...
    • Amyloid beta-Peptide Oligomers Stimulate RyR-Mediated Ca(2+) Release Inducing Mitochondrial Fragmentation in Hippocampal Neurons and Prevent RyR-Mediated Dendritic Spine Remodeling Produced by BDNF 

      Paula Lima, Andrea; Adasme, Tatiana; San Martín Rovirosa, Carol; Sebollela, Adriano; Hetz Flores, Claudio; Carrasco Friz, María Angélica; Ferreira, Sergio T.; Hidalgo Tapia, María Cecilia (MARY ANN LIEBERT INC, 2011-04)
      Soluble amyloid beta-peptide oligomers (A beta Os), increasingly recognized as causative agents of Alzheimer's disease (AD), disrupt neuronal Ca(2+) homeostasis and synaptic function. Here, we report that A beta Os at ...
    • Amyloid β-peptide oligomers stimulate RyR-mediated Ca2+ release inducing mitochondrial fragmentation in hippocampal neurons and prevent RyR-mediated dendritic spine remodeling produced by BDNF 

      Paula Lima, Andrea; Adasme, Tatiana; San Martín Rovirosa, Carol; Sebollela, Adriano; Hetz Flores, Claudio; Carrasco, M. Angélica; Ferreira, Sergio T.; Hidalgo Tapia, María Cecilia (2011)
      Soluble amyloid β-peptide oligomers (AβOs), increasingly recognized as causative agents of Alzheimer's disease (AD), disrupt neuronal Ca2+ homeostasis and synaptic function. Here, we report that AβOs at sublethal concentrations ...
    • Amyotrophic lateral sclerosis pathogenesis: A journey through the secretory pathway 

      Nassif, Melissa; Matus, Soledad; Castillo, Karen; Hetz Flores, Claudio (2010)
      Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motoneuron degenerative disease characterized by the selective loss of motoneurons in the spinal ventral horn, most brainstem nuclei, and the cerebral ...
    • An ERcentric view of Parkinson's disease 

      Mercado, Gabriela; Valdés, Pamela; Hetz Flores, Claudio (2013)
      Parkinson's disease (PD) is the second most common neurodegenerative disease and is characterized by the selective loss of dopaminergic neurons of the substantia nigra pars compacta and the accumulation of intracellular ...