Now showing items 1-13 of 13

    • Assessing chaperone for Zn, Cu-superoxide dismutase as an indicator of copper deficiency in malnourished children 

      Arredondo Olguín, Miguel; Weisstaub Nuta, Sergio; Medina, Marcos; Suazo Romo, Miriam; Guzmán, Miguel; Araya, Magdalena (Elsevier, 2014)
      It is not clear how frequent is copper deficiency in humans. Current copper markers are not sensitive enough to detect early copper deficiency and new markers are needed. CCS is a candidate to become a copper ...
    • Association between ferritin and hepcidin levels and inflammatory status in patients with type 2 diabetes mellitus and obesity 

      Andrews, Mónica; Soto, Néstor; Arredondo Olguín, Miguel (Elsevier, 2015)
      Objective: The aim of this study was to determine the association between iron parameters and inflammation in obese individuals with and without type 2 diabetes mellitus (T2DM). Methods: We studied 132 obese individuals ...
    • CCS mRNA transcripts and serum CCS protein as copper marker in adults suffering inflammatory processes 

      Araya, Magdalena; Gutiérrez, Ricardo; Arredondo Olguín, Miguel (Springer, 2014)
      The chaperone to Zn–Cu superoxide dismutase (CCS) has been postulated as a candidate copper indicator, changing in a consistent manner in induced and recovered copper deficiency, in experimental cell and animal models. ...
    • Effect of Calcium, Tannic Acid, Phytic Acid and Pectin over Iron Uptake in an In Vitro Caco-2 Cell Model 

      Andrews, Mónica; Briones, L.; Jaramillo, A.; Pizarro Aguirre, Fernando; Arredondo Olguín, Miguel (Springer, 2014)
      Calcium, phytic acid, polyphenols and fiber are major inhibitors of iron absorption and they could be found in excess in some diets, thereby altering or modifying the iron nutrition status. The purpose of this study is ...
    • Effect of phytic acid etchant on the structural stability of demineralized dentine and dentine bonding 

      Jaramillo, Ángela; Briones, Lautaro; Andrews, Mónica; Arredondo Olguín, Miguel; Olivares Grohnert, Manuel; Brito, Alex; Pizarro Aguirre, Fernando (Elsevier, 2015)
      Objective: To determine the effect of phytic acid, tannic acid and pectin on fasting non-heme iron bioavailability in both the presence and absence of calcium. Research methods: Twenty-eight apparently healthy adult ...
    • The Effect of Plant Proteins Derived from Cereals and Legumes on Heme Iron Absorption 

      Weinborn, Valerie; Pizarro Aguirre, Fernando; Olivares Grohnert, Manuel; Brito, Alex; Arredondo Olguín, Miguel; Flores, Sebastián; Valenzuela Venegas, Carolina (MDPI AG, 2015)
      The aim of this study is to determine the effect of proteins from cereals and legumes on heme iron (Fe) absorption. The absorption of heme Fe without its native globin was measured. Thirty adult females participated in two ...
    • The effect of proteins from animal source foods on heme iron bioavailability in humans 

      Pizarro Aguirre, Fernando; Olivares Grohnert, Manuel; Valenzuela Venegas, Carolina; Brito, Alex; Weinborn, Valerie; Flores, Sebastián; Arredondo Olguín, Miguel (Elsevier, 2016)
      Forty-five women (35-45 year) were randomly assigned to three iron (Fe) absorption sub-studies, which measured the effects of dietary animal proteins on the absorption of heme Fe. Study 1 was focused on heme, red blood ...
    • Effects of acute dietary iron overload in pigs (sus scrofa) with induced type 2 diabetes mellitus 

      Espinoza, A.; Morales, S.; Arredondo Olguín, Miguel (Springer, 2014)
      Epidemiological studies have reported an association between high iron (Fe) levels and elevated risk of developing type 2 diabetes mellitus (T2D). It is believed that the formation of Fe-catalyzed hydroxyl radicals may ...
    • Effects of chronic copper exposure during early life in rhesus monkeys 

      Araya, Magdalena; Kelleher, Shannon; Arredondo Olguín, Miguel; Sierralta, Walter; Vial, María Teresa; Uauy Dagach-Imbarack, Ricardo; Lonnerdal, Bo (AMER SOC CLINICAL NUTRITION, 2005-05)
      Background: Whether infants regulate copper absorption and the potential effects of excess copper in early life remain poorly defined. Objective: The objective of the study was to assess copper retention, liver copper ...
    • Mouse divalent metal transporter 1 is a copper transporter in HEK293 cells 

      Arredondo Olguín, Miguel; Mendiburo Seguel, María José; Flores, Sebastián; Singleton, Steven T.; Garrick, Michael D. (Springer Science+Business Media, 2014)
      Divalent Metal Transporter 1 (DMT1) is an apical Fe transporter in the duodenum and is involved in endosomal Fe export. Four protein isoforms have been described for DMT1, two from mRNA with an iron responsive element ...
    • Prebiotics increase heme iron bioavailability and do not affect non-heme iron bioavailability in humans 

      Weinborn, Valerie; Valenzuela Venegas, Carolina; Olivares, Manuel; Arredondo Olguín, Miguel; Weill, Ricardo; Pizarro Aguirre, Fernando (Royal Soc Chemistry, 2017-05-01)
      The aim of this study was to establish the effect of a prebiotic mix on heme and non-heme iron (Fe) bioavailability in humans. To this purpose, twenty-four healthy women were randomized into one of two study groups. One ...
    • Understanding copper homeostasis in humans and copper effects on health 

      Araya, Magdalena; Pizarro Aguirre, Fernando; Olivares Grohnert, Manuel; Arredondo Olguín, Miguel; González Canales, Mauricio; Méndez, Marco (2006)
    • Zinc as a potential coadjuvant in therapy for type 2 diabetes 

      Ruz Ortíz, Manuel; Carrasco Naranjo, Fernando; Rojas Mondaca, Pamela; Codoceo, Juana; Inostroza Escobar, Jorge; Basfi-fer Obregón, Karen; Valencia Canessa, Alejandra; Vásquez, Karla; Galgani Fuentes, José; Pérez, Alvaro; López, Gloria; Arredondo Olguín, Miguel; Pérez Bravo, Francisco (The United Nations University, 2013)
      Background: Type 2 diabetes is highly prevalent in populations having high rates of overweight and obesity. It is a chronic condition responsible for long-term severe dysfunction of several organs, including the ...