Now showing items 1-7 of 7

    • Comparative spectroscopic and electrochemical study of nitroindazoles: 3-Alcoxy, 3-hydroxy and 3-oxo derivatives 

      Rodríguez Borges, Jorge; Olea Azar, Claudio; Barriga, Germán; Folch, Christian; Gerpe, Alejandra; Cerecetto, Hugo; González, Mercedes (PERGAMON-ELSEVIER SCIENCE LTD, 2008-08)
      Cyclic voltammetry and electron spin resonance techniques were used in the investigation of novel 3-alkoxy- and 3-hydroxy-1-[omega-(dialkylamino)alkyl]-5-nitroindazole derivatives. A self-protonation process involving the ...
    • ESR and electrochemical study of 5-nitroindazole derivatives with antiprotozoal activity 

      Olea Azar, Claudio; Cerecetto, Hugo; Gerpe, Alejandra; González, Mercedes; Arán, Vicente J.; Rigol Olsen, Carolina; Opazo, Lucía (PERGAMON-ELSEVIER SCIENCE LTD, 2006-01)
      The electrochemistry of 3-alkoxy- and 3-hydroxy-1-[(omega-(dialkylamino)alkyl]-5-nitroindazole derivatives were characterized using cyclic voltammetry in DMSO. The nitro reduction process was studied and this was affected ...
    • In vitro and in vivo antitrypanosomatid activity of 5-nitroindazoles 

      Boiani, Lucia; Gerpe, Alejandra; Arán, Vicente J.; Torres de Ortiz, Susana; Serna, Elva; Vera de Bilbao, Ninfa; Sanabria, Luis; Yaluff, Gloria; Nakayama, Héctor; Rojas de Arias, Antonieta; Maya Arango, Juan; Morello, J. Antonio; Cerecetto, Hugo; González, Mercedes (2009)
      Previously, we have identified a series of 5-nitroindazoles with good antiprotozoal activities, against Trypanosoma cruzi epimastigotes and Trichomonas vaginalis. Most of them have shown very low unspecific toxicity on ...
    • Indazole N-oxide derivatives as antiprotozoal agents: Synthesis, biological evaluation and mechanism of action studies 

      Gerpe, Alejandra; Aguirre, Gabriela; Boiani, Lucía; Cerecetto, Hugo; González, Mercedes; Olea Azar, Claudio; Rigol Olsen, Carolina; Maya Arango, Juan; Morello Casté, Antonio; Piro, Oscar E.; Arán, Vicente J.; Azqueta, Amaia; López de Ceráin, Adela; Monge, Antonio; Rojas, María Antonieta; Yaluff, Gloria (PERGAMON-ELSEVIER SCIENCE LTD, 2006-05-15)
      A series of indazole N-oxide derivatives have been synthesized and their antichagasic and leishmanocidal properties studied. 3-Cyano-2-(4-iodophenyl)-2H-indazole N-1-oxide exhibited interesting antichagasic activity on the ...
    • New heteroaryl nitrones with spin trap properties: Identification of a 4-furoxanyl derivative with excellent properties to be used in biological systems 

      Barriga, Germán; Olea Azar, Claudio; Norambuena, Ester; Castro, Ana; Porcal, Williams; Gerpe, Alejandra; González, Mercedes; Cerecetto, Hugo (ELSEVIER, 2010)
      A new series of heteroaryl nitrones, 1–7, bearing furoxanyl and thiadiazolyl moieties, were evaluated for their free radical-trapping properties. The physicochemical characterization by electron paramagnetic resonance ...
    • Study of 5-nitroindazoles' anti-Trypanosoma cruzi mode of action: Electrochemical behaviour and ESR spectroscopic studies 

      Rodríguez, Jorge; Gerpe, Alejandra; Aguirre, Gabriela; Kemmerling Weis, Ulrike; Piro, Oscar E.; Arán, Vicente J.; Maya Arango, Juan; Olea Azar, Claudio; González, Mercedes; Cerecetto, Hugo (2009)
      New indazole derivatives have been developed to know about structural requirements for adequate anti-Trypanosoma cruzi activity. In relation to position 1 of indazole ring, we have observed that a butylaminopentyl substituent ...
    • Study of 5-nitroindazoles' anti-Trypanosoma cruzi mode of action: Electrochemical behaviour and ESR spectroscopic studies 

      Rodríguez Borges, Jorge; Gerpe, Alejandra; Aguirre, Gabriela; Kemmerling Weis, Ulrike; Piro, Oscar E.; Arán, Vicente J.; Maya Arango, Juan; Olea Azar, Claudio; González, Mercedes; Cerecetto, Hugo (ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 2009-04)
      New indazole derivatives have been developed to know about structural requirements for adequate anti-Trypanosoma cruzi activity. In relation to position 1 of indazole ring, we have observed that a butylaminopentyl substituent ...