Browsing by Author "a6804978-6c9a-4b0f-9922-f2c7dda160f9"

Now showing items 1-7 of 7

    • A tRNA(Glu) that uncouples protein and tetrapyrrole biosynthesis 
      Levicán, Gloria; Katz, Assaf; Valenzuela, Patricio; Söll, Dieter; Orellana, Omar (2005)
      Glu-tRNA is either bound to elongation factor Tu to enter protein synthesis or is reduced by glutamyl-tRNA reductase (GluTR) in the first step of tetrapyrrole biosynthesis in most bacteria, archaea and in chloroplasts. ...
    • Cellular levels of heme affect the activity of dimeric glutamyl-tRNA reductase 
      Armas-Ricard, Merly de; Levicán, Gloria; Katz, Assaf; Moser, Jurgen; Jahn, Dieter; Orellana Orellana, Omar (Elsevier, 2011-02-04)
      Glutamyl-tRNA reductase (GluTR) is the first enzyme committed to tetrapyrrole biosynthesis by the C(5)-pathway. This enzyme transforms glutamyl-tRNA into glutamate-1-semi-aldehyde, which is then transformed into 5-amino ...
    • EF-P Dependent Pauses Integrate Proximal and Distal Signals during Translation 
      Elgamal, Sara; Katz, Assaf; Hersch, Steven J.; Newsom, David; White, Peter; Navarre, William Wiley; Ibba, Michael (Public Library of Science, 2014)
      © 2014 Elgamal et al. Elongation factor P (EF-P) is required for the efficient synthesis of proteins with stretches of consecutive prolines and other motifs that would otherwise lead to ribosome pausing. However, previous ...
    • Modification of transfer RNA levels affects cyclin aggregation and the correct duplication of yeast cells 
      Arias, Loreto; Martínez, Fabián; González, Daniela; Flores Ríos, Rodrigo; Katz, Assaf; Tello, Mario; Moreira, Sandra; Orellana, Omar (Frontiers Media, 2021)
      Codon usage bias (the preferential use of certain synonymous codons (optimal) over others is found at the organism level (intergenomic) within specific genomes (intragenomic) and even in certain genes. Whether it is the ...
    • Oxidative stress damages rRNA inside the ribosome and differentially affects the catalytic center 
      Willi, Jessica; Kupfer, Pascal; Evequoz, Damien; Fernández, Guillermo; Katz, Assaf; Leumann, Christian; Polacek, Norbert (Oxford University Press, 2018)
      Intracellular levels of reactive oxygen species (ROS) increase as a consequence of oxidative stress and represent a major source of damage to biomolecules. Due to its high cellular abundance RNA is more frequently the ...
    • Redox status affects the catalytic activity of glutamyl-tRNA synthetase 
      Katz, Assaf; Banerjee, Rajat; de Armas, Merly; Ibba, Michael; Orellana, Omar (Academic Press Inc., 2010)
      Glutamyl-tRNA synthetases (GluRS) provide Glu-tRNA for different processes including protein synthesis, glutamine transamidation and tetrapyrrole biosynthesis. Many organisms contain multiple GluRSs, but whether these ...
    • Regulation of a glutamyl-tRNA synthetase by the heme status 
      Levicán, Gloria; Katz, Assaf; De Armas, Merly; Núñez, Harold; Orellana, Omar (2007)
      Glutamyl-tRNA (Glu-tRNA), formed by Glu-tRNA synthetase (GluRS), is a substrate for protein biosynthesis and tetrapyrrole formation by the C 5 pathway. In this route Glu-tRMA is transformed to δ-aminolevulinic acid, the ...