Browsing by Author "afc989b2-76d9-45b6-923c-4ca38801a208"

Now showing items 1-3 of 3

    • Mll-COMPASS complexes mediate H3K4me3 enrichment and transcription of the osteoblast master gene Runx2/p57 ... 
      Rojas, Adriana; Sepúlveda, Hugo; Henríquez, Berta; Aguilar, Rodrigo; Opazo, Tatiana; Nardocci, Gino; Bustos, Fernando; Lian, Jane B.; Stein, Janet L.; Stein, Gary S.; van Zundert, Brigitte; van Wijnen, Andre J.; Allende Connelly, Miguel; Montecino, Martín (Wiley, 2019)
      Expression of Runx2/p57 is a hallmark of the osteoblast-lineage identity. Although several regulators that control the expression of Runx2/p57 during osteoblast-lineage commitment have been identified, the epigenetic ...
    • Polycomb PRC2 complex mediates epigenetic silencing of a critical osteogenic master regulator in the hippocampus 
      López Aguilar, Rodrigo; Bustos, Fernando J.; Sáez, Mauricio; Rojas, Adriana; Allende Connelly, Miguel; van Wijnen, Andre J.; van Zundert, Brigitte; Montecino, Martín (Elsevier, 2016)
      During hippocampal neuron differentiation, the expression of critical inducers of non-neuronal cell lineages must be efficiently silenced. Runx2 transcription factor is the master regulator of mesenchymal cells responsible ...
    • Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent ... 
      Jury, Nur; Abarzúa, Sebastián; Díaz, Iván; Guerra, Miguel V.; Ampuero, Estibaliz; Cubillos, Paula; Martínez, Pablo; Herrera Soto, Andrea; Arredondo, Cristian; Rojas, Fabiola; Manterola Zúñiga, Marcia; Rojas, Adriana; Montecino, Martín; Varela Nallar, Lorena; van Zundert, Brigitte (BMC, 2020)
      Background Hexanucleotide repeat expansions of the G(4)C(2) motif in a non-coding region of the C9ORF72 gene are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Tissues ...