Now showing items 1-7 of 7

    • ADAR1 Transcriptome editing promotes breast cancer progression through the regulation of cell cycle and DNA damage response 

      Sagredo, Eduardo A.; Sagredo, Alfredo I.; Blanco, Alejandro; Rojas De Santiago, Pamela; Rivas, Solange; Assar Cuevas, Rodrigo; Pérez, Paola; Marcelain Cubillos, Katherine; Armisen Yáñez, Ricardo (Elsevier, 2020)
      RNA editing has emerged as a novel mechanism in cancer progression. The double stranded RNA-specific adenosine deaminase (ADAR) modifies the expression of an important proportion of genes involved in cell cycle control, ...
    • ADAR1-mediated RNA-editing of 3'UTRs in breast cancer 

      Sagredo, Eduardo A.; Blanco, Alejandro; Sagredo, Alfredo I.; Pérez, Paola; Sepúlveda-Hermosilla, Gonzalo; Morales, Fernanda; Müller, Bettina; Verdugo, Ricardo; Marcelain Cubillos, Katherine; Harismendy, Olivier; Armisén, Ricardo (NLM (Medline), 2018)
      RESULTS: We characterized A to G(I) mRNA editing in 81 breast cell lines, showing increased editing at 3'UTR and exonic regions in breast cancer cells compared to immortalized non-malignant cell lines. In addition, tumors ...
    • Mucin 5B, carbonic anhydrase 9 and claudin 18 are potential theranostic markers of gallbladder carcinoma 

      Espinoza, Jaime A.; Riquelme, Ismael; Sagredo, Eduardo A.; Rosa, Lorena; García, Patricia; Bizama, Carolina; Apud-Bell, María; Leal, Pamela; Weber, Helga; Benavente, Felipe; Vargas, Sergio; Romero, Diego; Kalergis, Alexis M.; Roa, Juan Carlos (Blackwell Publishing Ltd, 2019)
      Aims: Gallbladder cancer (GBC) is an aggressive tumour that is usually diagnosed at advanced stages and is characterised by a poor prognosis. Using public data of normal human tissues, we found that mRNA and protein levels ...
    • TRPM4 channel is involved in regulating epithelial to mesenchymal transition, migration, and invasion of prostate cancer cell lines 

      Sagredo, Alfredo I.; Sagredo, Eduardo A.; Pola, Victor; Echeverría, César; Andaur, Rodrigo; Michea Acevedo, Luis; Stutzin Schottlander, Andrés; Simon, Felipe; Marcelain Cubillos, Katherine; Armisén, Ricardo (Wiley-Liss Inc., 2019)
      © 2018 Wiley Periodicals, Inc. Transient Receptor Potential Melastatin 4 (TRPM4) is a Ca 2+ -activated and voltage-dependent monovalent cation channel, which depolarizes the plasma cell membrane, thereby modulating Ca 2+ ...
    • TRPM4 channel is involved in regulating epithelial to mesenchymal transition, migration, and invasion of prostate cancer cell lines 

      Sagredo, Alfredo I.; Sagredo, Eduardo A.; Pola, Victor; Echeverría, César; Andaur, Rodrigo; Michea Acevedo, Luis; Stutzin Schottlander, Andrés; Simon, Felipe; Marcelain Cubillos, Katherine; Armisén, Ricardo (Wiley-Liss Inc., 2018)
      © 2018 Wiley Periodicals, Inc. Transient Receptor Potential Melastatin 4 (TRPM4) is a Ca2+-activated and voltage-dependent monovalent cation channel, which depolarizes the plasma cell membrane, thereby modulating Ca2+ ...
    • TRPM4 regulates Akt/GSK3-b activity and enhances b-catenin signaling and cell proliferation in prostate cancer cells 

      Sagredo, A.; Sagredo, Eduardo A.; Cappelli, Claudio; Baez, Pablo; Andaur, Rodrigo E.; Blanco, Constanza; Tapia, Julio C.; Echeverría, César; Cerda, Oscar; Stutzin Schottlander, Andrés; Simon, Felipe; Marcelain Cubillos, Katherine; Armisen Yáñez, Ricardo (Febs Press Science Publishing by Scientist, 2018)
      Increased expression of the TRPM4 channel has been reported to be associated with the progression of prostate cancer. However, the molecular mechanism underlying its effect remains unknown. This work found that decreasing ...
    • TRPM4 regulates Akt/GSK3-β activity and enhances β-catenin signaling and cell proliferation in prostate cancer cells 

      Sagredo, Alfredo I.; Sagredo, Eduardo A.; Cappelli, Claudio; Báez, Pablo; Andaur, Rodrigo E.; Blanco, Constanza; Tapia, Julio C.; Echeverría, César; Cerda, Oscar; Stutzin Schottlander, Andrés; Simon, Felipe; Marcelain Cubillos, Katherine; Armisén, Ricardo (John Wiley and Sons Ltd., 2018)
      © 2017 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. Increased expression of the TRPM4 channel has been reported to be associated with the progression of prostate cancer. However, the molecular mechanism ...