Now showing items 1-20 of 27

    • Cardiovascular aging Envejecimiento cardiovascular 

      Domenech Lira, Raúl; Macho Fisher, Pilar (2008)
      Aging produces its own cardiovascular changes, mainly remodelling of arteries, heart and the microcirculation. These progressive changes, detected since adolescence, represent a major risk factor for the development of ...
    • Changes in total and transmural coronary blood flow induced by ethanol 

      Pescio, Sergio; Macho Fisher, Pilar; Penna Varela, Mario; Domenech Lira, Raúl (Oxford University Press, 1983)
      Summary: We studied the effects of ethanol on total coronary resistance and on the resistance across the left ventricular wall in the isolated empty beating heart of the dog. The coronaries were perfused with homologous ...
    • Contractilidad ventricular. Fisiología y proyección clínica 

      Domenech Lira, Raúl; Parra Morales, Víctor (Soc Médica Santiago, 2016)
      The contractile state of the heart is the result of myocardial contractility, the intrinsic mechanism that regulates the force and the shortening of the ventricle and determines the ventricular ejection volume. However, ...
    • Effect of heart rate on regional coronary blood flow 

      Domenech Lira, Raúl; Goich, Jaime (1976)
      The effect of tachycardia on the distribution of coronary blood flow was studied in the dog heart using the radioactive microsphere technique. Increasing heart rate from 1.7 to 3.0 Hz produced an increment of flow to the ...
    • Effect of heart rate on regional coronary blood flow 

      Domenech Lira, Raúl; Goich, Jaime (Oxford University Press, 1976)
      AUTHORS' SYNOPSIS: The effect of tachycardia on the distribution of coronary blood flow was studied in the dog heart using the radioactive microsphere technique. Increasing heart rate from 1.7 to 3.0 Hz produced an increment ...
    • Effect of left intraventricular pressure on magnitude of vascular waterfall in the epicardial coronary veins 

      Domenech Lira, Raúl; Macho Fisher, Pilar; Barros, Felipe (Oxford University Press, 1990)
      Study objective - The aim was to test the hypothesis of a vascular waterfall in the epicardial veins due to compression by the left ventricular (LV) pressure. If this were so, the epicardial venous pressure should be a ...
    • Effect of tachycardia on myocardial sarcoplasmic reticulum and Ca2+ dynamics: a mechanism for preconditioning? 

      Domenech Lira, Raúl; Sánchez, Gina; Donoso Laurent, Paulina; Parra Morales, Víctor; Macho Fisher, Pilar (ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 2003-12)
      We have previously demonstrated that brief episodes of tachycardia prior to a prolonged occlusion of a coronary artery, followed by reperfusion, substantially reduce the infarct size. Adenosine receptors and mitochondrial ...
    • Envejecimiento cardiovascular 

      Domenech Lira, Raúl; Macho Fisher, Pilar (SOC MEDICA SANTIAGO, 2008-12)
      Aging produces its own cardiovascular changes, mainly remodelling of arteries, heart and the microcirculation. These progressive changes, detected since adolescence, represent a major risk factor for the development of ...
    • Exercise and tachycardia increase NADPH oxidase and ryanodine receptor-2 activity: Possible role in cardioprotection 

      Sánchez, Gina; Escobar, Matías; Pedrozo Cibils, Zully; Macho Fisher, Pilar; Domenech Lira, Raúl; Härtel, Steffen; Hidalgo Tapia, María Cecilia; Donoso Laurent, Paulina (2008)
      Aim: Our objective was to investigate in cardiac muscle the contribution of NADPH oxidase to (a) ryanodine receptor-2 (RyR2) S-glutathionylation and (b) the preconditioning effects of exercise and tachycardia on infarct ...
    • Exercise induces early and late myocardial preconditioning in dogs 

      Domenech Lira, Raúl; Macho Fisher, Pilar; Schwarze, Hermann; Sánchez, Gina (2002)
      Objective: We tested the hypothesis that exercise induces myocardial preconditioning in dogs. Methods: We instrumented dogs with a snare on the anterior descending coronary artery and catheters in the root of the aorta, ...
    • Exercise preconditioning of myocardial infarct size in dogs is triggered by calcium 

      Parra, Víctor M.; Macho Fisher, Pilar; Sánchez, Gina; Donoso Laurent, Paulina; Domenech Lira, Raúl (Lippincott Williams and Wilkins, 2015)
      © 2014 Wolters Kluwer Health, Inc. All rights reserved.We showed that exercise induces early and late myocardial preconditioning in dogs and that these effects are mediated through nicotinamide adenine dinucleotide phosphate ...
    • Exercise preconditioning of myocardial infarct size in dogs is triggered by calcium 

      Parra, Víctor M.; Macho Fisher, Pilar; Sánchez, Gina; Donoso Laurent, Paulina; Domenech Lira, Raúl (Lippincott Williams and Wilkins, 2015)
      © 2014 Wolters Kluwer Health, Inc. All rights reserved.We showed that exercise induces early and late myocardial preconditioning in dogs and that these effects are mediated through nicotinamide adenine dinucleotide phosphate ...
    • Late cardiac preconditioning by exercise in dogs is mediated by mitochondrial potassium channels 

      Parra, Víctor M.; Macho Fisher, Pilar; Domenech Lira, Raúl (2010)
      We previously showed that exercise induces myocardial preconditioning in dogs and that early preconditioning is mediated through mitochondrial adenosine triphosphate-sensitive potassium channels. We decided to study if ...
    • Maternal supplementation with antioxidant vitamins in sheep results in increased transfer to the fetus and improvement of fetal antioxidant status and development 

      Sales, Francisco; Peralta, Oscar A.; Narbona, Eileen; McCoard, Sue; Lira, Raúl; Reyes Solovera, Mónica de los; González Bulnes, Antonio; Parraguez Gamboa, Víctor (MDPI, 2019)
      Twinning and maternal nutritional restriction leads to fetal hypoxia, oxidative stress, and intrauterine growth restriction (IUGR) in near-term sheep pregnancies. Our aim was to determine the effect of oral supplementation ...
    • Mechanical effects of heart contraction on coronary flow 

      Domenech Lira, Raúl; De La Prida, (1975)
      The mechanical effects of heart contraction on coronary flow were studied in the dog heart by implanting vessels in the subendocardial and subepicardial layers of the left ventricular wall and perfusing them independently ...
    • Mechanical effects of heart contraction on coronary flow 

      Domenech Lira, Raúl; De La Prida, Julio M. (Oxford University Press, 1975)
      AUTHORS' SYNOPSIS: The mechanical effects of heart contraction on coronary flow were studied in the dog heart by implanting vessels in the subendocardial and subepicardial layers of the left ventricular wall and perfusing ...
    • Non-ischemic myocardial preconditioning 

      Domenech Lira, Raúl; Macho Fisher, Pilar (1998)
      The reduction of infarct size produced by brief ischemic episodes prior to a sustained occlusion of a coronary artery, called ischemic preconditioning, is a well known phenomenon that occurs in several species, but its ...
    • Preconditioning - A new concept about the benefit of exercise 

      Domenech Lira, Raúl (LIPPINCOTT WILLIAMS & WILKINS, 2006-01-03)
      Case presentation: A 45-yearold man with coronary artery disease is found to be in good condition after his annual medical checkup, and his doctor advises him to continue with the same drugs, a prudent diet, ...
    • Preconditioning tachycardia decreases the activity of the mitochondrial permeability transition pore in the dog heart 

      Sánchez, Gina; Fernández, Carolina; Montecinos, Luis; Domenech Lira, Raúl; Donoso Laurent, Paulina (2011)
      Cardioprotection by preconditioning is a central issue of current research on heart function. Several reports indicate that preventing the assembly and opening of the mitochondrial permeability transition pore (mPTP) ...
    • Relative participation of adenosine and endothelium derived mediators in coronary reactive hyperemia in the dog 

      Macho Fisher, Pilar; Domenech Lira, Raúl; Penna Varela, Mario (1995)
      The metabolites that mediate coronary reactive hyperemia have not been definitely identified. Although adenosine and endothelium derived substances seem to be involved, their relative contributions have not been defined ...