Browsing by Author "bfd6fdf3-b25f-4085-93d9-aae5af50cd64"

Now showing items 1-13 of 13

    • A Thyroid Genetic Classifier Correctly Predicts Benign Nodules with Indeterminate Cytology: Two Independent, ... 
      Zafereo, Mark; McIver, Bryan; Vargas Salas, Sergio; Domínguez, Jose; Steward, David L.; Holsinger, F. Christopher; Kandil, Emad; Williams, Michelle; Loyola, Soledad; Solar, Antonieta; Roa, Juan; Leon, Augusto; Droppelman, Nicolas; Lobos, Maite; Arias, Tatiana; Kong, Christina S.; Busaidy, Naifa; Grubbs, Elizabeth G.; Graham, Paul; Stewart, John; Tang, Alice; Wang, Jiang; Orloff, Lisa; Henriquez, Marcela; Lagos, Marcela; Osorio, Miren; Schachter, Dina; Franco, Carmen; Medina, Francisco; Wohllk Gonzalez, Nelson; Diaz, Rene; Veliz Lopez, Jesus; Horvath, Eleonora; Tala, Hernan; Pineda Bravo, Pedro; Arroyo Albala, Patricia; Vásquez, Felix; Traipe, Eufrosina; Marin, Luis; Miranda, Giovanna; Bruce, Elsa; Bracamonte, Milagros; Mena, Natalia; Gonzalez, Hernan E. (Mary Ann Liebert, 2020)
      Background: Although most thyroid nodules with indeterminate cytology are benign, in most of the world, surgery remains as the most frequent diagnostic approach. We have previously reported a 10-gene thyroid genetic ...
    • Cell death induced by mitochondrial complex I inhibition is mediated by Iron Regulatory Protein 
      Urrutia, Pamela J.; Aguirre, Pabla; Tapia, Victoria; Carrasco, Carlos M.; Mena, Natalia P.; Núñez González, Marco (Elsevier, 2017)
      Mitochondrial dysfunction and oxidative damage, often accompanied by elevated intracellular iron levels, are pathophysiological features in a number of neurodegenerative processes. The question arises as to whether ...
    • Cell death induced by mitochondrial complex I inhibition is mediated by Iron Regulatory Protein 1 
      Urrutia, Pamela J.; Aguirre, Pabla; Tapia, Victoria; Carrasco, Carlos M.; Mena, Natalia P.; Núñez González, Marco (Elsevier B.V., 2017)
      © 2017 Elsevier B.V. Mitochondrial dysfunction and oxidative damage, often accompanied by elevated intracellular iron levels, are pathophysiological features in a number of neurodegenerative processes. The question arises ...
    • Corrigendum to “The novel mitochondrial iron chelator 5-((methylamino)methyl)-8-hydroxyquinoline protects ... 
      Mena, Natalia P.; García Beltrán, Olimpo; Lourido, Fernanda; Urrutia, Pamela J.; Mena, Raúl; Castro Castillo, Vicente; Cassels Niven, Bruce; Núñez González, Marco (Elsevier, 2016)
    • A coumarinylaldoxime as a specific sensor for Cu2+ and its biological application 
      García Beltrán, Olimpo; Cassels Niven, Bruce; Mena, Natalia P.; Núñez González, Marco; Yáñez, Osvaldo; Caballero, Julio (Elsevier, 2014)
      In this Letter we present a new probe, (E)-7-(diethylamino)-2-oxo-2H-chromene-3-carbaldehyde oxime (JB), which can detect Cu2+ ions in HEPES buffer under physiological conditions. Benesi–Hildebrand and Job plots demonstrate ...
    • Dysfunction of mitochondrial Lon protease and identification of oxidized protein in mouse brain following ... 
      Bulteau, Anne Laure; Mena, Natalia P.; Auchere, Francoise; Lee, Irene; Prigent, Annick; Lobsiger, Christian S.; Camadro, Jean Michel; Hirsch, Etienne C. (Elsevier, 2017)
      Compelling evidence suggests that mitochondrial dysfunction leading to reactive oxygen species (ROS) production and protein oxidation could represent a critical event in the pathogenesis of Parkinson's disease (PD). ...
    • Effect of mitochondrial complex I inhibition on Fe-S cluster protein activity 
      Mena, Natalia P.; Bulteau, Anne Laure; Salazar, Julio; Hirsch, Etienne C.; Núñez González, Marco (2011)
      Iron-sulfur (Fe-S) clusters are small inorganic cofactors formed by tetrahedral coordination of iron atoms with sulfur groups. Present in numerous proteins, these clusters are involved in key biological processes such as ...
    • Erratum: The novel mitochondrial iron chelator 5-((methylamino)methyl)-8-hydroxyquinoline protects against ... 
      Mena, Natalia P.; García Beltrán, Olimpo; Lourido, Fernanda; Urrutia, Pamela J.; Mena, Raúl; Castro Castillo, Vicente; Cassels Niven, Bruce; Núñez González, Marco (Elsevier B.V., 2016)
    • Hepcidin inhibits apical iron uptake in intestinal cells 
      Mena, Natalia P.; Esparza, Andrés; Tapia, Victoria; Valdés, Pamela; Núñez González, Marco (2007)
      Hepcidin (Hepc) is considered a key mediator in iron trafficking. Although the mechanism of Hepc action in macrophages is fairly well established, much less is known about its action in intestinal cells, one of the main ...
    • Iron chelators and antioxidants regenerate neuritic tree and nigrostriatal fibers of MPP+/MPTP-Lesioned ... 
      Aguirre, Pabla; Mena, Natalia P.; Carrasco, Carlos M.; Muñoz, Yorka; Pérez Henríquez, Patricio; Morales, Rodrigo A.; Cassels Niven, Bruce; Méndez Gálvez, Carolina; García Beltrán, Olimpo; González Billault, Christian; Núñez González, Marco (Public Library of Science, 2015)
      © 2015 Aguirre et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in anymedium, provided the original ...
    • Synthesis of coumarin derivatives as fluorescent probes for membrane and cell dynamics studies 
      García Beltrán, Olimpo; Yáñez, Osvaldo; Caballero, Julio; Galdámez Silva, Antonio; Mena, Natalia P.; Núñez González, Marco; Cassels Niven, Bruce (Elsevier, 2014)
      Three coumarin-derived fluorescent probes, 3-acetyl-7-[(6-bromohexyl)oxy]-2H-chromen-2-one (FM1), 7-[(6-bromohexyl)oxy]-4-methyl-2H-chromen-2-one (FM2) and ethyl 2-{7-[(6-bromohexyl)oxy]-2-oxo- 2H-chromen-4-yl}acetate ...
    • The development of a fluorescence turn-on sensor for cysteine, glutathione and other biothiols. A kinetic study 
      García Beltrán, Olimpo; Mena, Natalia P.; Pérez, Edwin G.; Cassels Niven, Bruce; Núñez González, Marco; Werlinger, Francisca; Zavala, Daniel; Aliaga, Margarita E.; Pavez, Paulina (Elsevier Ltd., 2011-10-06)
      Two fluorescence probes for the detection of cysteine (Cys), glutathione (GSH) and other biothiols, such as homocysteine (Hcy) and cysteinyl-glycine (Cys-Gly), were developed. These molecular probes are coumarin-based ...
    • The interplay between iron accumulation, mitochondrial dysfunction, and inflammation during the execution ... 
      Urrutia, Pamela J.; Mena, Natalia P.; Núñez González, Marco (Frontiers Media SA, 2014)
      A growing set of observations points to mitochondrial dysfunction, iron accumulation, oxidative damage and chronic inflammation as common pathognomonic signs of a number of neurodegenerative diseases that includes Alzheimer's ...