Now showing items 1-3 of 3

    • Antiangiogenic, antimigratory and antiinflammatory effects of 2-methoxyestradiol in zebrafish larvae 

      Quezada, Marisol; Alvarez, Marjorie; Peña, Oscar A.; Henríquez, Soledad; Alençon, Claudia A. d'; Lange, Soledad; Oliva, Barbara; Owen, Gareth I.; Allende Connelly, Miguel (Elsevier, 2012-11-07)
      2-Methoxyestradiol (2ME), an endogenous metabolite of 17β-estradiol, has been previously reported to possess antiangiogenic and antitumor properties. Herein, we demonstrate that the effects of this antiangiogenic steroid ...
    • Independent Anti-Angiogenic Capacities of Coagulation Factors X and Xa 

      Lange, Soledad; Gonzalez, Ibeth; Pinto, Mauricio P.; Arce, Maximiliano; Valenzuela, Rodrigo; Aranda, Evelyn; Elliot, Matias; Alvarez, Marjorie; Henriquez, Soledad; Velasquez, Ethel V.; Orge, Felipe; Oliva, Barbara; Gonzalez, Pamela; Villalon, Manuel; Cautivo, Kelly M.; (Wiley-Liss Inc., 2014)
      Knockout models have shown that the coagulation system has a role in vascular development and angiogenesis. Herein, we report for the first time that zymogen FX and its active form (FXa) possess anti-angiogenic properties. ...
    • Progesterone promotes focal adhesion formation and migration in breast cancer cells through induction of protease-activated receptor-1 

      Diaz, Jorge; Aranda, Evelyn; Henriquez, Soledad; Quezada, Marisol; Espinoza, Estefanía; Bravo, Maria Loreto; Oliva, Bárbara; Lange, Soledad; Villalon, Manuel; Jones, Marius; Brosens, Jan J.; Kato, Sumie; Cuello, Mauricio A.; Knutson, Todd P.; Lange, Carol A.; Leyton, Li (2012)
      Progesterone and progestins have been demonstrated to enhance breast cancer cell migration, although the mech- anisms are still not fully understood. The protease-activated receptors (PARs) are a family of membrane receptors ...