Browsing by Author "c64ba364-c0b0-4254-accd-7fe8b5ba52c6"

Now showing items 1-5 of 5

    • Autophagosomes cooperate in the degradation of intracellular C-terminal fragments of the amyloid precursor ... 
      González, Alexis E.; Muñoz, Vanessa C.; Cavieres, Viviana A.; Bustamante, Hianara A.; Cornejo, Víctor Hugo; Januário, Yunan C.; González, Ibeth; Hetz Flores, Claudio; Dasilva, Luis L.; Rojas-Fernández, Alejandro; Hay, Ronald T.; Mardones, Gonzalo A.; Burgos, Patricia V. (FASEB, 2017)
      © FASEB. Brain regions affected by Alzheimer disease (AD) displaywell-recognized early neuropathologic features in the endolysosomal and autophagy systems of neurons, including enlargement of endosomal compartments, ...
    • ER stress signaling and neurodegeneration: At the intersection between Alzheimer's disease and Prion-related ... 
      Torres, Mauricio; Matamala, José Manuel; Durán Aniotz, Claudia; Cornejo, Víctor Hugo; Foley, Andrew; Hetz Flores, Claudio (Elsevier, 2015)
      © 2014 Elsevier B.V. Alzheimer's and Prion diseases are two neurodegenerative conditions sharing different pathophysiological characteristics. Disease symptoms are associated with the abnormal accumulation of protein ...
    • Global and local mechanisms sustain axonal proteostasis of transmembrane proteins 
      Cornejo, Víctor Hugo; Luarte, Alejandro; Couve, Andrés (Blackwell Munksgaard, 2017)
      © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd The control of neuronal protein homeostasis or cursive is tightly regulated both spatially and temporally, assuring accurate and integrated responses to ...
    • Golgi bypass for local delivery of axonal proteins, fact or fiction? 
      González, Carolina; Cornejo, Víctor Hugo; Couve, Andrés (Elsevier Ltd, 2018)
      © 2018 Although translation of cytosolic proteins is well described in axons, much less is known about the synthesis, processing and trafficking of transmembrane and secreted proteins. A canonical rough endoplasmic reticulum ...
    • Role of the unfolded protein response in organ physiology: lessons from mouse models 
      Cornejo, Víctor Hugo; Pihán, Philippe; Vidal, René Luis; Hetz Flores, Claudio (2013)
      The endoplasmic reticulum (ER) is a key subcellular compartment involved in the folding and maturation of around one-third of the total proteome. Accumulation of misfolded proteins in the ER lumen engages a signal transduction ...