Browsing by Author "ce00d440-d36c-4eff-8346-54dfbfe16ab4"

Now showing items 1-16 of 16

    • Cinaciguat Reduces Prolyl Hydroxylase 2 (PHD2) protein expression in chronically hypoxic and pulmonary ... 
      Beñaldo Fuentes, Felipe; Araya Quijada, Claudio; Serón Ferre, María; Herrera Videla, Emilio; Ebensperger Darrouy, Germán; Reyes Catalán, Víctor; Llanos Mansilla, Jorge (Wiley, 2020)
    • Evolving in thin air-Lessons from the llama fetus in the altiplano 
      Llanos Mansilla, Jorge; Riquelme, Raquel A.; Herrera, Emilio A.; Ebensperger Darrouy, Germán; Krause, Bernardo; Reyes, Roberto V.; Sanhueza, Emilia M.; Pulgar, Víctor M.; Behn, Claus; Cabello, Gertrudis; Parer, Julian T.; Giussani, Dino A.; Blanco, Carlos E.; Hanson, Mark A. (2007)
      Compared with lowland species, fetal life for mammalian species whose mothers live in high altitude is demanding. For instance, fetal llamas have to cope with the low fetal arterial PO2 of all species, but also the likely ...
    • Fetal and postnatal pulmonary circulation in the Alto Andino 
      Llanos Mansilla, Jorge; Ebensperger Darrouy, Germán; Herrera Videla, Emilio; Reyes, R. V.; Pulgar, V. M.; Serón Ferré, María; Díaz Beneventi, Mauricio; Parer, J. T.; Giussani, Dino A.; Moraga, F. A.; Riquelme González, Raquel (Elsevier, 2011)
      Lowland mammals at high altitude constrict the pulmonary vessels, augmenting vascular resistance and developing pulmonary arterial hypertension. In contrast, highland mammals, like the llama, do not present pulmonary ...
    • Long-term exposure to high-altitude chronic hypoxia during gestation induces neonatal pulmonary hypertension ... 
      Herrera, Emilio A.; Riquelme, Raquel A.; Ebensperger Darrouy, Germán; Reyes, Roberto V.; Ulloa, César E.; Cabello, Gertrudis; Krause, Bernardo J.; Parer, Julian T.; Giussani, Dino A.; Llanos Mansilla, Jorge (2010)
      We determined whether postnatal pulmonary hypertension induced by 70% of pregnancy at high altitude (HA) persists once the offspring return to sea level and investigated pulmonary vascular mechanisms operating under these ...
    • Melatonin decreases pulmonary vascular remodeling and oxygen sensitivity in pulmonary hypertensive newborn lambs 
      Astorga, Cristian R.; González Candia, Alejandro; Figueroa, Esteban G.; Cañas, Daniel; Ebensperger Darrouy, Germán; Reyes Catalán, Víctor; Llanos Mansilla, Jorge; Herrera Videla, Emilio; Candia, Alejandro A. (Frontiers media SA, 2018)
      Background: Chronic hypoxia and oxidative stress during gestation lead to pulmonary hypertension of the neonate (PHN), a condition characterized by abnormal pulmonary arterial reactivity and remodeling. Melatonin has strong ...
    • Melatonin long-lasting beneficial effects on pulmonary vascular reactivity and redox balance in chronic ... 
      González Candia, Alejandro; Candia, Alejandro A.; Figueroa, Esteban G.; Feixes, Elisenda; González Candia, Cristopher; Aguilar, Simón A.; Ebensperger, Germán; Reyes, Roberto V.; Llanos, Aníbal J.; Herrera, Emilio A. (Wiley, 2020)
      Pulmonary arterial hypertension of the neonate (PAHN) is a pathophysiological condition characterized by maladaptive pulmonary vascular remodeling and abnormal contractile reactivity. This is a multifactorial syndrome ...
    • Perinatal cardiopulmonary adaptation to the thin air of the Alto Andino by a native Altiplano dweller, the llama 
      Reyes Catalán, Víctor; Herrera Videla, Emilio; Ebensperger Darrouy, Germán; Sanhueza Reinoso, Emilia; Giussani, D. A.; Llanos Mansilla, Jorge (American Physiological Society, 2020)
      Most mammals have a poor tolerance to hypoxia, and prolonged O-2 restriction can lead to organ injury, particularly during fetal and early postnatal life. Nevertheless, the llama (Lama Glama) has evolved efficient mechanisms ...
    • Plasmatic concentrations of ADMA and homocystein in llama (Lama glama) and regulation of arginase type II: ... 
      López, Vasthi; Moraga, Fernando A.; Llanos Mansilla, Jorge; Ebensperger Darrouy, Germán; Taborda, María I.; Uribe, Elena (Frontiers Media SA., 2018-05-29)
      There are animal species that have adapted to life at high altitude and hypobaric hypoxia conditions in the Andean highlands. One such species is the llama (Lama glama), which seem to have developed efficient protective ...
    • Potential adverse effects of antenatal melatonin as a treatment for intrauterine growth restriction: findings ... 
      González Candia, Alejandro; Véliz, Marcelino; Araya, Claudio; Quezada, Sebastián; Ebensperger Darrouy, Germán; Serón Ferré, María; Reyes, Roberto V.; Llanos Mansilla, Jorge; Herrera Videla, Emilio (Mosby-Elsevier, 2016)
      BACKGROUND: Intrauterine growth restriction is a condition in which the fetus has a birthweight and/or length <10th percentile for the gestational age. Intrauterine growth restriction can be associated with various causes, ...
    • Revisiting the role of TRP, orai, and ASIC channels in the pulmonary arterial response to hypoxia 
      Reyes, Roberto V.; Castillo Galán, Sebastián; Hernández, Ismael; Herrera, Emilio A.; Ebensperger Darrouy, Germán; Llanos Mansilla, Jorge (Frontiers Media S.A., 2018)
      © 2018 Reyes, Castillo-Galán, Hernandez, Herrera, Ebensperger and Llanos. The pulmonary arteries are exquisitely responsive to oxygen changes. They rapidly and proportionally contract as arterial PO2 decrease, and they ...
    • Role of the RhoA/ROCK pathway in high-altitude associated neonatal pulmonary hypertension in lambs 
      López, Nandy; Ebensperger Darrouy, Germán; Herrera Videla, Emilio; Reyes, Roberto V.; Calaf, Gloria; Cabello, Gertrudis; Moraga, Fernando; Benaldo, Felipe A.; Díaz, Marcela; Parer, Julian T.; Llanos Mansilla, Jorge (Amer Physiological Soc, 2016)
      Exposure to high-altitude chronic hypoxia during pregnancy may cause pulmonary hypertension in neonates, as a result of vasoconstriction and vascular remodeling. We hypothesized that susceptibility to pulmonary hypertension, ...
    • Role of the α-adrenergic system in femoral vascular reactivity in neonatal llamas and sheep: A comparative ... 
      Moraga, Fernando A.; Reyes, Roberto V.; Herrera, Emilio A.; Riquelme, Raquel A.; Ebensperger Darrouy, Germán; Pulgar, Víctor M.; Parer, Julian T.; Giussani, Dino A.; Llanos Mansilla, Jorge (2011)
      Using an integrative approach at the whole animal, isolated vessels, and molecular levels, we tested the hypothesis that the llama, a species that undergoes pregnancy under the influence of the chronic hypoxia of high ...
    • Study of the Effect of Treatment With Atrial Natriuretic Peptide (ANP) and Cinaciguat in Chronic Hypoxic ... 
      Navarrete, Álvaro; Chen, Zhuoming; Aranda, Pedro; Poblete, Daniel; Utrera, Andrés; García Herrera, Claudio; González Candia, Alejandro; Beñaldo, Felipe A.; Ebensperger Darrouy, Germán; Reyes, Roberto V.; Herrera Videla, Emilio; Llanos, Aníbal J. (Frontiers Media, 2020)
      In this study, we assessed the effects of Atrial Natriuretic Peptide (ANP) and Cinaciguat, as experimental medicines to treat neonatal lambs exposed to chronic hypoxic conditions. To compare the different treatments, the ...
    • The heme oxygenase-carbon monoxide system in the regulation of cardiorespiratory function at high altitude 
      Llanos Mansilla, Jorge; Ebensperger Darrouy, Germán; Herrera, Emilio A.; Reyes, Roberto V.; Cabello, Gertrudis; Díaz Díaz, Marcela Cecilia; Giussani, Dino A.; Parer, Julian T. (2012)
      Pulmonary arterial hypertension is one of the most serious pathologies that can affect the 140 million people living at altitudes over 2500. m. The primary emphasis of this review is pulmonary artery hypertension in mammals ...
    • The newborn sheep translational model for pulmonary arterial hypertension of the neonate at high altitude 
      González Candia, Alejandro; Candia Henríquez, Alejandro; Ebensperger Darrouy, Germán; Reyes, Roberto V.; Llanos, Anibal J.; Herrera Videla, Emilio (Cambridge University Press, 2020)
      Chronic hypoxia during gestation induces greater occurrence of perinatal complications such as intrauterine growth restriction, fetal hypoxia, newborn asphyxia, and respiratory distress, among others. This condition may ...
    • The role of nitric oxide in the cardiopulmonary response to hypoxia in highland and lowland newborn llamas 
      Reyes, Roberto V.; Díaz Díaz, Marcela Cecilia; Ebensperger Darrouy, Germán; Herrera, Emilio A.; Quezada, Sebastián A.; Hernández, Ismael; Sanhueza, Emilia M.; Parer, Julian T.; Giussani, Dino A.; Llanos Mansilla, Jorge (Blackwell Publishing Ltd, 2018)
      © 2018 The Physiological Society. Key points: Perinatal hypoxia causes pulmonary hypertension in neonates, including humans. However, in species adapted to hypoxia, such as the llama, there is protection against pulmonary ...