Browsing by Author "d2ba86fb-22fc-4738-b770-2d08d1658518"

Now showing items 1-8 of 8

    • ATP release due to Thy-1-integrin binding induces P2X7-mediated calcium entry required for focal adhesion formation 
      Henríquez, Mauricio; Herrera Molina, Rodrigo; Valdivia, Alejandra; Alvarez, Alvaro; Kong, Milene; Muñoz, Nicolás; Eisner, Verónica; Jaimovich Pérez, Enrique; Schneider, Pascal; Quest, Andrew F. G.; Leyton Campos, Lisette (2011)
      Thy-1, an abundant mammalian glycoprotein, interacts with avβ3 integrin and syndecan-4 in astrocytes and thus triggers signaling events that involve RhoA and its effector p160ROCK, thereby increasing astrocyte adhesion to ...
    • beta -Hydroxybutyrate increases exercise capacity associated with changes in mitochondrial function in ... 
      Monsalves Álvarez, Matías; Morales Campos, Pablo; Castro Sepúlveda, Mauricio; Sepúlveda Guzmán, Carlos; Rodríguez Silva, Juan Manuel; Chiong Lay, Mario; Eisner, Verónica; Lavandero González, Sergio; Troncoso Cotal, Rodrigo (MDPI, 2020)
      beta-hydroxybutyrate is the main ketone body generated by the liver under starvation. Under these conditions, it can sustain ATP levels by its oxidation in mitochondria. As mitochondria can modify its shape and function ...
    • Down syndrome critical region 1 gene, Rcan1, helps maintain a more fused Mitochondrial Network 
      Parra Ortíz, María Valentina; Altamirano, Francisco; Hernández Fuentes, Carolina; Tong, Dan; Kyrychenko, Victoriia; Rotter, David; Pedrozo Cibils, Zully; Hill, Joseph A.; Eisner, Verónica; Lavandero González, Sergio; Schneider, Jay W.; Rothermel, Beverly A. (Lippincott Williams & Wilkins, 2018)
      Rationale: The regulator of calcineurin 1 (RCAN1) inhibits CN (calcineurin), a Ca2+-activated protein phosphatase important in cardiac remodeling. In humans, RCAN1 is located on chromosome 21 in proximity to the Down ...
    • Hyperosmotic stress activates p65/RelB NFκB in cultured cardiomyocytes with dichotomic actions on caspase ... 
      Eisner, Verónica; Quiroga, Clara; Criollo Céspedes, Alfredo; Eltit Ortega, José Miguel; Chiong Lay, Mario; Parra, Valentina; Hidalgo, Karla; Toro, Barbra; Díaz Araya, Guillermo; Lavandero González, Sergio (2006)
      NFκB is a participant in the process whereby cells adapt to stress. We have evaluated the activation of NFκB pathway by hyperosmotic stress in cultured cardiomyocytes and its role in the activation of caspase and cell ...
    • Hyperosmotic stress-dependent NFκB activation is regulated by reactive oxygen species and IGF-1 in cultured ... 
      Eisner, Verónica; Criollo Céspedes, Alfredo; Quiroga, Clara; Olea Azar, Claudio; Santibañez, Juan Francisco; Troncoso, Rodrigo; Chiong Lay, Mario; Díaz Araya, Guillermo; Foncea, Rocío; Lavandero González, Sergio (2006)
      We have recently shown that hyperosmotic stress activates p65/RelB NFκB in cultured cardiomyocytes with dichotomic actions on caspase activation and cell death. It remains unexplored how NFκB is regulated in cultured rat ...
    • Inhibition of chymotrypsin-like activity of the proteasome by ixazomib prevents mitochondrial dysfunction ... 
      Sánchez Vergara, Gina; Chalmers, Stefanie; Ahumada, Xavier; Montecinos, Luis; Olmedo Alegría, Ivonne Odette; Eisner, Verónica; Riveros, Ana; Kogan, Marcelo J.; Lavandero González, Sergio; Pedrozo Cibils, Zully; Donoso Laurent, Paulina (Public Library Science, 2020)
      The heart is critically dependent on mitochondrial respiration for energy supply. Ischemia decreases oxygen availability, with catastrophic consequences for cellular energy systems. After a few minutes of ischemia, the ...
    • Muscle function decline and mitochondria changes in middle age precede sarcopenia in mice 
      Campo, Andrea del; Contreras Hernández, Ignacio Alejandro; Castro Sepúlveda, Mauricio; Campos, Cristian; Figueroa, Reinaldo; Florencia Tevy, María; Eisner, Verónica; Casas Atala, Mariana; Jaimovich Pérez, Enrique (Impact Journals LLC, 2018)
      Sarcopenia is the degenerative loss of muscle mass and strength with aging. Although a role of mitochondrial metabolism in muscle function and in the development of many diseases has been described, the role of mitochondrial ...
    • Skeletal muscle excitation-metabolism coupling 
      Díaz Vegas, Alexis; Eisner, Verónica; Jaimovich Pérez, Enrique (Academic Press Inc., 2019)
      Mitochondria represent the main source of ATP in skeletal muscle and mitochondria activity increases after muscle fiber depolarization. The regulation of mitochondrial function during contraction in skeletal muscle, however, ...