Now showing items 1-17 of 17

    • Delivery of gold nanoparticles to the brain by conjugation with a peptide that recognizes the transferrin receptor 

      Prades, Roger; Guerrero, Simón; Araya, Eyleen; Molina, Claudia; Salas, Edison; Zurita, Esther; Selva, Javier; Egea, Gustavo; López-Iglesias, Carmen; Teixidó, Meritxell; Kogan Bocian, Marcelo; Giralt, Ernest (2012)
      The treatment of Alzheimer's disease and many other brain-related disorders is limited because of the presence of the blood-brain barrier, which highly regulate the crossing of drugs. Metal nanoparticles have unique features ...
    • Determination of mefenamic acid and paracetamol by first derivative spectrophotometry 

      Toral Ponce, María; Richter Duk, Pablo; Araya, Eyleen; Fuentes, Sandra (Marcel Dekker Inc., 1996)
    • Exploring the influence of diels–alder linker length on photothermal molecule release from gold nanorods 

      Vetterlein, Claudia; Vásquez Salfate, Rodrigo; Bolaños, Karen; Acosta, Gerardo A.; Guzman, Fanny; Albericio, Fernando; Celis, Freddy; Campos, Marcelo; Kogan Bocian, Marcelo; Araya, Eyleen (Elsevier, 2018-06)
      We studied the photothermal release of carboxyfluorescein (CF) linked to the gold surface of gold nanorods (GNRs) by two Diels-Alder adducts of different lengths (n = 4 and n = 9). The functionalized GNRs were irradiated ...
    • Exploring the influence of Diels–Alder linker length on photothermal molecule release from gold nanorods 

      Vetterlein, Claudia; Vásquez Salfate, Rodrigo; Bolaños, Karen; Acosta, Gerardo A.; Guzman, Fanny; Albericio, Fernando; Celis, Freddy; Campos, Marcelo; Kogan Bocian, Marcelo; Araya, Eyleen (Elsevier B.V., 2018)
      © 2018 Elsevier B.V. We studied the photothermal release of carboxyfluorescein (CF) linked to the gold surface of gold nanorods (GNRs) by two Diels–Alder adducts of different lengths (n = 4 and n = 9). The functionalized ...
    • Gold Nanoparticles and Microwave Irradiation Inhibit Beta-Amyloid Amyloidogenesis 

      Araya, Eyleen; Olmedo, Ivonne; Bastus, Neus G.; Guerrero, Simón; Puntes, Víctor F.; Giralt, Ernest; Kogan Bocian, Marcelo (SPRINGER, 2008-11)
      Peptide-Gold nanoparticles selectively attached to beta-amyloid protein (A beta) amyloidogenic aggregates were irradiated with microwave. This treatment produces dramatic effects on the A beta aggregates, inhibiting both ...
    • Gold nanoparticles for photothermally controlled drug release 

      Guerrero, Ariel R.; Hassan, Natalia; Escobar, Carlos A.; Albericio, Fernando; Kogan Bocian, Marcelo; Araya, Eyleen (Future Medicine Ltd., 2014)
      © 2014 Future Medicine Ltd. In this article, we describe how nanoparticles work in photothermally triggered drug delivery, starting with a description of the plasmon resonance and the photothermal effect, and how this is ...
    • Gold nanoparticles for selective and remote heating of β-amyloid protein aggregates 

      Bastus, Neus G.; Kogan Bocian, Marcelo; Amigo, Roger; Grillo-Bosch, Dolors; Araya, Eyleen; Turiel, Antonio; Labarta, Amilcar; Giralt, Ernest; Puntes, Victor F. (2007)
      Nanoparticles can be made to respond resonantly to a time-varying electromagnetic field with advantageous results related to the transfer of energy from the exciting field to the nanoparticles. The surface of each particle ...
    • How Changes in the Sequence of the Peptide CLPFFD-NH2 Can Modify the Conjugation and Stability of Gold Nanoparticles and Their Affinity for B-Amyloid Fibrils 

      Olmedo, Ivonne; Araya, Eyleen; Sanz, Fausto; Medina, Elias; Arbiol, Jordi; Toledo, Pedro; Álvarez Lueje, Alejandro; Giralt, Ernest; Kogan Bocian, Marcelo (American Chemical Society, 2008-05-30)
      In a previous work, we studied the interaction of -amyloid fibrils (A ) with gold nanoparticles (AuNP) conjugated with the peptide CLPFFD-NH2. Here, we studied the effect of changing the residue sequence of the ...
    • How changes in the sequence of the peptide CLPFFD-NH2 can modify the conjugation and stability of gold nanoparticles and their affinity for beta-amyloid fibrils 

      Olmedo Alegría, Ivonne Odette; Araya, Eyleen; Sanz, F.; Medina Consuegra, Elías Daniel; Arbiol, Jordi; Toledo, P.; Álvarez Lueje, Alejandro; Giralt, Ernest; Kogan Bocian, Marcelo (AMER CHEMICAL SOC, 2008-06)
      In a previous work, we studied the interaction of P-amyloid fibrils (A beta) with gold nanoparticles (AuNP) conjugated with the peptide CLPFFD-NH2. Here, we studied the effect of changing the residue sequence of the peptide ...
    • Improving gold nanorod delivery to the central nervous system by conjugation to the shuttle Angiopep-2 

      Velasco Aguirre, Carolina; Morales Zavala, Francisco; Salas Huenuleo, Edison; Gallardo Toledo, Eduardo; Andonie, Oscar; Muñoz, Luis; Rojas, Ximena; Acosta, Gerardo; Sánchez Navarro, Macarena; Giralt, Ernest; Araya, Eyleen; Albericio, Fernando; Kogan Bocian, Marcelo (Future Medicine, 2017)
      Aim: To improve the in vivo delivery of gold nanorods (GNRs) to the central nervous system of rats, these gold nanoparticles were conjugated to Angiopep-2, a shuttle peptide that can cross the blood-brain barrier. Materials ...
    • Improving the brain delivery of gold nanoparticles by conjugation with an amphipathic peptide 

      Guerrero, Simon; Araya, Eyleen; Fiedler Temer, Jenny; Arias, J. Ignacio; Adura, Carolina; Albericio, Fernando; Giralt, Ernest; Arias, José Luis; Fernández, María Soledad; Kogan Bocian, Marcelo (2010)
      Background & Aims: Gold nanoparticles (GNPs) have promising applications for drug delivery as well as for the diagnosis and treatment of several pathologies, such as those related to the CNS. However, GNPs are retained in ...
    • Metal Nanoparticles for the Treatment and Diagnosis of Neurodegenerative Brain Diseases 

      Vio, Valentina; Marchant, María José; Araya, Eyleen; Kogan Bocian, Marcelo (Bentham Science Publishers Ltd., 2017)
      This review focuses on the application of metal nanoparticles in the diagnosis and treatment of Alzheimer's and Parkinson's diseases. Metal nanoparticles present interesting physicochemical properties that can be applied ...
    • Nanoparticle-mediated local and remote manipulation of protein aggregation 

      Kogan Bocian, Marcelo; Bastus, Neus G.; Amigo, Roger; Grillo-Bosch, Dolors; Araya, Eyleen; Turiel, Antonio; Labarta, Amilcar; Giralt, Ernest; Puntes, Víctor F. (AMER CHEMICAL SOC, 2006-01)
      The local heat delivered by metallic nanoparticles selectively attached to their target can be used as a molecular surgery to safely remove toxic and clogging aggregates. We apply this principle to protein aggregates, in ...
    • Peptide multifunctionalized gold nanorods decrease toxicity of beta-amyloid peptide in a Caenorhabditis elegans model of Alzheimer's disease 

      Morales Zavala, Francisco; Arriagada, Hector; Hassan, Natalia; Velasco, Carolina; Riveros Salvatierra, Ana; Álvarez, Alejandra R.; Minniti, Alicia N.; Rojas Silva, Ximena; Munoz, Luis L.; Vásquez Salfate, Rodrigo; Rodríguez, Katherine; Sánchez Navarro, Macarena; Giralt, Ernest; Araya, Eyleen; Aldunate, Rebeca; Kogan Bocian, Marcelo (Elsevier, 2017)
      The properties of nanometric materials make nanotechnology a promising platform for tackling problems of contemporary medicine. In this work, gold nanorods were synthetized and stabilized with polyethylene glycols and ...
    • Peptides and proteins used to enhance gold nanoparticle delivery to the brain: preclinical approaches 

      Velasco Aguirre, Carolina; Morales, Francisco; Gallardo Toledo, Eduardo; Guerrero, Simón; Giralt, Ernest; Araya, Eyleen; Kogan Bocian, Marcelo (Dove Medical Press, 2015)
      An exciting and emerging field in nanomedicine involves the use of gold nanoparticles (AuNPs) in the preclinical development of new strategies for the treatment and diagnosis of brain-related diseases such as neurodegeneration ...
    • Permanganometría de hierro y titanio utilizando análisis por inyección en flujo 

      Richter Duk, Pablo; Toral Ponce, María; Parra Ortíz, María Valentina; Fuentes, Sandra; Araya, Eyleen (Sociedad Chilena de Química, 1995)
      Se desarrolla un método automático de análisis por inyección en flujo (FIA) para la determinación simultánea de hierro y titanio en mezclas. El método se basa en el diseño de una configuración FIA que incluye la reducción ...
    • Sensing immobilized molecules of streptavidin on a silicon surface by maldi-tof mass spectrometry and fluorescence microscopy 

      Araya, Eyleen; Kogan Bocian, Marcelo; Guell, Aleix G.; Escobar, Carlos A.; Sanz, Fausto (2014)
      A hydrogen-terminated Si (111) surface was modified to form an aminoterminated monolayer for immobilization of streptavidin. Cleavage of an N-(ω- undecylenyl)-phthalimide covered surface using hidrazine yields an amino ...