Now showing items 1-7 of 7

    • Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state? 

      Peña Oyarzún, Daniel; Bravo Sagua, Roberto; Díaz Vega, Alexis; Aleman, Larissa; Chiong Lay, Mario; Garcia, Lorena; Bambs, Claudia; Troncoso, Rodrigo; Cifuentes, Mariana; Morselli, Eugenia; Ferreccio, Catterina; Quest, Andrew F. G.; Criollo Céspedes, Alfredo; Lavandero González, Sergio (Elsevier Inc., 2018)
      © 2018 Elsevier Inc. Non-communicable diseases (NCDs), also known as chronic diseases, are long-lasting conditions that affect millions of people around the world. Different factors contribute to their genesis and progression; ...
    • BAG3 regulates total MAP1LC3B protein levels through a translational but not transcriptional mechanism 

      Rodríguez, Andrea E.; López Crisosto, Camila; Peña Oyarzún, Daniel; Salas, Daniela; Parra A., Valentina; Quiroga, Clara; Morawe, Tobías; Chiong Lay, Mario; Behl, Christian; Lavandero González, Sergio (Taylor and Francis, 2016)
      Autophagy is mainly regulated by post-translational and lipid modifications of ATG proteins. In some scenarios, the induction of autophagy is accompanied by increased levels of certain ATG mRNAs such as MAP1LC3B/LC3B, ATG5 ...
    • GLP-1 promotes mitochondrial metabolism in vascular smooth muscle cells by enhancing endoplasmic reticulum-mitochondria coupling 

      Morales, Pablo E.; Torres, Gloria; Sotomayor Flores, Cristian Alejandro; Peña Oyarzún, Daniel; Rivera Mejías, Pablo; Paredes, Felipe; Chiong Lay, Mario (Academic Press Inc., 2014)
      Incretin GLP-1 has important metabolic effects on several tissues, mainly through the regulation of glucose uptake and usage. One mechanism for increasing cell metabolism is modulating endoplasmic reticulum (ER)-mitochondria ...
    • GLP-1 promotes mitochondrial metabolism in vascular smooth muscle cells by enhancing endoplasmic reticulum–mitochondria coupling 

      Morales, Pablo E.; Torres, Gloria; Sotomayor Torres, Cristian; Peña Oyarzún, Daniel; Rivera Mejías, Pablo; Paredes, Felipe; Chiong Lay, Mario (Elsevier, 2014)
      Incretin GLP-1 has important metabolic effects on several tissues, mainly through the regulation of glucose uptake and usage. One mechanism for increasing cell metabolism is modulating endoplasmic reticulum (ER)–mitochondria ...
    • Hyperosmotic stress stimulates autophagy via polycystin-2 

      Peña Oyarzún, Daniel; Troncoso Cotal, Rodrigo; Kretschmar, Catalina; Hernando, Cecilia; Budini, Mauricio; Morselli, Eugenia; Lavandero González, Sergio; Criollo Céspedes, Alfredo (Impact Journals, 2017)
      Various intracellular mechanisms are activated in response to stress, leading to adaptation or death. Autophagy, an intracellular process that promotes lysosomal degradation of proteins, is an adaptive response to several ...
    • Rol de BAG3 en la regulación del metabolismo muscular esquelético 

      Peña Oyarzún, Daniel (Universidad de Chile, 2014)
      La proteína co-chaperona Bag3 es un factor clave en el control de la autofagia selectiva, un proceso de degradación de proteínas y organelos activado en respuesta a distintos estresores, en tejidos altamente diferenciados, ...
    • Role of heterotrimeric G protein and calcium in cardiomyocyte hypertrophy induced by IGF-1 

      Carrasco Mujica, Loreto; Cea, Paola; Rocco, Paola; Peña Oyarzún, Daniel; Rivera Mejías, Pablo; Sotomayor Flores, Cristian Alejandro; Quiroga, Clara; Criollo Céspedes, Alfredo; Ibarra, Cristian; Chiong Lay, Mario; Lavandero González, Sergio (Wiley-Liss, 2014)
      In the heart, insulin‐like growth factor‐1 (IGF‐1) is a peptide with pro‐hypertrophic and anti‐apoptotic actions. The pro‐hypertrophic properties of IGF‐1 have been attributed to the extracellular regulated kinase (ERK) ...