Now showing items 1-6 of 6

    • ADAR1 Transcriptome editing promotes breast cancer progression through the regulation of cell cycle and DNA damage response 

      Sagredo, Eduardo A.; Sagredo, Alfredo I.; Blanco, Alejandro; Rojas De Santiago, Pamela; Rivas, Solange; Assar Cuevas, Rodrigo; Pérez, Paola; Marcelain Cubillos, Katherine; Armisen Yáñez, Ricardo (Elsevier, 2020)
      RNA editing has emerged as a novel mechanism in cancer progression. The double stranded RNA-specific adenosine deaminase (ADAR) modifies the expression of an important proportion of genes involved in cell cycle control, ...
    • ADAR1-mediated RNA-editing of 3'UTRs in breast cancer 

      Sagredo, Eduardo A.; Blanco, Alejandro; Sagredo, Alfredo I.; Pérez, Paola; Sepúlveda-Hermosilla, Gonzalo; Morales, Fernanda; Müller, Bettina; Verdugo, Ricardo; Marcelain Cubillos, Katherine; Harismendy, Olivier; Armisén, Ricardo (NLM (Medline), 2018)
      RESULTS: We characterized A to G(I) mRNA editing in 81 breast cell lines, showing increased editing at 3'UTR and exonic regions in breast cancer cells compared to immortalized non-malignant cell lines. In addition, tumors ...
    • Development of a small panel of SNPs to infer ancestry in chileans that distinguishes Aymara and Mapuche components 

      Verdugo Salgado, Ricardo; Di Genova, Alex; Herrera Cisterna, Luisa; Moraga Vergara, Mauricio; Acuña Patzke, Mónica; Berríos del Solar, María Soledad; Llop Romero, Elena; Valenzuela, Carlos Y.; Bustamante Calderón, María Leonor; Digman, Dayhana; Symon Maturana, Adriana; Asenjo, Soledad; López Contreras, Pamela; Blanco, Alejandro E.; Suazo Sanhueza, José; Barozet, Emmanuelle; Caba, Fresia; Villalón Calderón, Marcelo; Alvarado Orellana, Sergio; Cáceres Lillo, Dante; Salgado, Katherine; Portales, Pilar; Moreno Estrada, Andrés; Gignoux, Christopher; Sandoval, Karla; Bustamante, Carlos; Eng, Celeste; Huntsman, Scott; Burchard, Esteban; Loira, Nicolás; Maass Sepúlveda, Alejandro; Cifuentes Ovalle, Lucía (Sociedad de Biología de Chile, 2020)
      Background Current South American populations trace their origins mainly to three continental ancestries, i.e. European, Amerindian and African. Individual variation in relative proportions of each of these ancestries may ...
    • Genomic identification of recent positive selection in populations from Andean highlands and south-central Chile 

      Contreras, Paloma S.; Blanco, Alejandro E.; Moreno Estrada, Andrés; Sandoval, Karla; Eng, Celeste; Huntsman, Scott; Burchard, Esteban G.; Gignoux, Christopher; Bustamante, Carlos; Llop Romero, Elena; Moraga, Mauricio; Verdugo, Ricardo (WILEY-BLACKWELL, 2016)
    • Genomic insights into the origin and diversification of late maritime hunter-gatherers from the chilean Patagonia 

      Fuente, Constanza de la; Galimany, Jacqueline; Blanco, Alejandro E.; Contreras, Paloma; Llop Romero, Elena; Verdugo, Ricardo; Moraga, Mauricio (Natl Acad Sciences, 2018)
      Patagonia was the last region of the Americas reached by humans who entered the continent from Siberia similar to 15,000-20,000 y ago. Despite recent genomic approaches to reconstruct the continental evolutionary history, ...
    • Insight into the population history of the Chilean Patagonia through the analysis of ancient and modern genomic data 

      Fuente, Constanza de la; Avila Arcos, María; Carpenter, Meredith L.; Homburger, Julian; Blanco, Alejandro; Contreras, Paloma; Moreno Estrada, Andrés; Campos, Paula F.; Eng, Celeste; Huntsman, Scott; Burchard, Esteban G.; Bustamante, Carlos; Willerslev, Eske; Llop Romero, Elena; Verdugo, Ricardo; Moraga Vergara, Mauricio (WILEY-BLACKWELL, 2016)