Browsing by Author "ed31ae79-5a96-4e0a-a73c-fd7dfae70140"

Now showing items 1-4 of 4

    • BCL-2 family: integrating stress responses at the ER to control cell demise 
      Pihan, Philippe; Carreras Sureda, Amado; Hetz Flores, Claudio (Nature Publishing Group, 2017)
      In the last decade, the endoplasmic reticulum (ER) has emerged as a central organelle regulating the core mitochondrial apoptosis pathway. At the ER membrane, a variety of stress signals are integrated toward determining ...
    • Calcium signaling at the endoplasmic reticulum: fine-tuning stress responses 
      Carreras Sureda, Amado; Pihan, Philippe; Hetz Flores, Claudio (Elsevier, 2018)
      Endoplasmic reticulum (ER) calcium signaling is implicated in a myriad of coordinated cellular processes. The ER calcium content is tightly regulated as it allows a favorable environment for protein folding, in addition ...
    • Getting intimate: lysosomes and ER rendezvous to control autophagy 
      Pihán, Philippe; Hetz Flores, Claudio (Elsevier, 2020)
      The endoplasmic reticulum (ER) is the source of lysosomal calcium. The finding that the protein TMBIM6 -a putative ER calcium channel and cell death regulator-promotes calcium transfer from the ER to lysosomes to induce ...
    • The UPRosome-decoding novel biological outputs of IRE1 alpha function 
      Urra, Hery; Pihan, Philippe; Hetz Flores, Claudio (Company Biologists, 2020)
      Different perturbations alter the function of the endoplasmic reticulum (ER), resulting in the accumulation of misfolded proteins in its lumen, a condition termed ER stress. To restore ER proteostasis, a highly conserved ...