Now showing items 1-12 of 12

    • Angiotensin II triggers apoptosis in cardiac fibroblast but not in myofibroblast overexpressing the type 1 receptor 

      Díaz Araya, Guillermo; Vivar Sánchez, Raúl; Soto, C.; Copaja, Miguel; Mateluna, F.; Aránguiz Urroz, Pablo Daniel; Muñoz, Juan Pablo; Chiong Lay, Mario; Thomas, W. G.; Lavandero González, Sergio (BLACKWELL PUBLISHING, 2007-07)
      Meeting Abstract
    • Attenuation of endoplasmic reticulum stress using the chemical chaperone 4-phenylbutyric acid prevents cardiac fibrosis induced by isoproterenol 

      Ayala, Pedro; Montenegro, José; Vivar, Raúl; Letelier, Alan; Urroz, Pablo Aránguiz; Copaja, Miguel; Pivet, Deisy; Humeres, Claudio; Troncoso, Rodrigo; Vicencio, José Miguel; Lavandero González, Sergio; Díaz Araya, Guillermo (2012)
      Increasing evidence indicates that endoplasmic reticulum (ER) stress is involved in various diseases. In the human heart, ischemia/reperfusion has been correlated to ER stress, and several markers of the unfolded protein ...
    • Beta(2)-adrenergic receptor regulates cardiac fibroblast autophagy and collagen degradation 

      Aránguiz Urroz, Pablo Daniel; Canales Urriola, Jimena Andrea; Copaja, Miguel; Troncoso Cotal, Rodrigo; Vicencio Bustamante, José Miguel; Carrillo Ballesteros, Constanza Carolina; Lara Peñaloza, Hernán; Lavandero González, Sergio; Díaz Araya, Guillermo (ELSEVIER SCIENCE BV, 2011-01)
      Autophagy is a physiological degradative process key to cell survival during nutrient deprivation, cell differentiation and development. It plays a major role in the turnover of damaged macromolecules and organelles, and ...
    • Beta2-adrenergic receptor regulates cardiac fibroblast autophagy and collagen degradation 

      Aránguiz Urroz, Pablo Daniel; Canales, Jimena; Copaja, Miguel; Troncoso, Rodrigo; Vicencio Bustamante, José Miguel; Carrillo, Constanza; Lara Peñaloza, Hernán; Lavandero González, Sergio; Díaz Araya, Guillermo (2011)
      Autophagy is a physiological degradative process key to cell survival during nutrient deprivation, cell differentiation and development. It plays a major role in the turnover of damaged macromolecules and organelles, and ...
    • Differential regulation of collagen secretion by kinin receptors in cardiac fibroblast and myofibroblast 

      Catalán, Mabel; Smolic, Christian; Contreras, Ariel; Ayala, Pedro; Olmedo, Ivonne; Copaja, Miguel; Boza Fuentes, Pía; Vivar, Raúl; Avalos, Yennifer; Lavandero González, Sergio; Velarde, Victoria; Díaz Araya, Guillermo (2012)
      Kinins mediate their cellular effects through B1 (B1R) and B2 (B2R) receptors, and the activation of B2R reduces collagen synthesis in cardiac fibroblasts (CF). However, the question of whether B1R and/or B2R have a role ...
    • Effects of carvedilol on oxidative stress and chronotropic response to exercise in patients with chronic heart failure 

      Castro, Pablo; Mc-Nab, Pablo; Quintana, Juan Carlos; Bittner, Alex; Greig, Douglas; Vergara, Ismael; Vukasovic Ramírez, José Luis; Corbalán, Ramón; Copaja, Miguel; Díaz Araya, Guillermo; Chiong Lay, Mario; Troncoso Cotal, Rodrigo; Alcaíno Gálvez, Hernán Alejandro; Lavandero González, Sergio (ELSEVIER SCIENCE BV, 2005-10)
      Background: Our previous studies suggest that the increase in heart rate from rest to peak exercise is reduced in patients with chronic heart failure (CHF) and this is associated with increased oxidative stress, as determined ...
    • Effects of Carvedilol upon intra- and interventricular synchrony in patients with chronic heart failure 

      Castro, Pablo; Mac Nab, Paul; Quintana, Juan Pablo; Bittner, Alex; Greig, Douglas; Vergara, I.; Vukasovic Ramírez, José Luis; Corbalán, Ramón; Copaja, Miguel; Díaz Araya, Guillermo; Chiong Lay, Mario; Troncoso Cotal, Rodrigo; Alcaíno Olivares, Hernán Alejandro; Lavandero González, Sergio (EXCERPTA MEDICA INC, 2005-07-15)
      Radionuclide isotopic ventriculography with phase analysis was performed in 30 patients with stable heart failure (HF), determining left ventricular (LV) and interventricular contraction synchrony at baseline and after 6 ...
    • Enalapril attenuates downregulation of angiotensin-converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat 

      Ocaranza, María Paz; Godoy, Iván; Jalil Milad, Jorge; Varas, Manuel; Collantes, Patricia; Pinto, Melissa; Román, Maritza; Ramírez, Cristián; Copaja, Miguel; Díaz Araya, Guillermo; Castro, Pablo; Lavandero González, Sergio (LIPPINCOTT WILLIAMS & WILKINS, 2006-10)
      The early and long-term effects of coronary artery ligation on the plasma and left ventricular angiotensin-converting enzyme (ACE and ACE2) activities, ACE and ACE2 mRNA levels, circulating angiotensin (Ang) levels [Ang ...
    • Phospholipase C/protein kinase C pathway mediates angiotensin II-dependent apoptosis in neonatal rat cardiac fibroblasts expressing AT1 receptor 

      Sánchez Vivar, Raúl; Soto, Cristián; Copaja, Miguel; Mateluna Guajardo, María Francisca; Aránguiz Urroz, Pablo Daniel; Muñoz, Juan Pablo; Chiong Lay, Mario; García Nannig, Lorena; Letelier Vargas, Alan Gonzalo; Thomas, W. G.; Lavandero González, Sergio; Díaz Araya, Guillermo (LIPPINCOTT WILLIAMS & WILKINS, 2008-08)
      Cardiac fibroblasts are the major non-myocyte cell constituent in the myocardium, and they are involved in heart remodeling. Angiotensin II type I receptor (AT(1)R), and changes in its expression have been reported in ...
    • Polimorfismos de los receptores - β Adrenérgicos y su relación con el riesgo de insuficiencia cardíaca, etiología y prevalencia de infarto al miocardio 

      Castro Gálvez, Pablo; Greig, Douglas; Copaja, Miguel; Alcaíno Olivares, Hernán Alejandro; Troncoso Cotal, Rodrigo Hernán; Chiong Lay, Mario; Mellado, Rose Marie; Pérez, Osvaldo; Vukasovic Ramírez, José Luis; Díaz Araya, Guillermo; Corbalán, Ramón; Ocaranza, María Paz; Jalil Milad, Jorge; Lavandero González, Sergio (Sociedad Chilena de Cardilología y Cirugía Cardiovascular, 2005)
      Los polimorfismos de los receptores β Adrenérgicos (AR) influencian el grado de actividad del receptor. Los βAR tienen un rol importante en la regulación de la contractilidad y podrían tener implicancias en el riesgo de ...
    • Simvastatin disrupts cytoskeleton and decreases cardiac fibroblast adhesion, migration and viability 

      Copaja, Miguel; Venegas, Daniel; Aranguiz, Pablo; Canales, Jimena; Vivar, Raúl; Avalos, Yennifer; García Nannig, Lorena; Chiong Lay, Mario; Olmedo, Ivonne; Catalán, Mabel; Leyton Campos, Lisette; Lavandero González, Sergio; Díaz Araya, Guillermo (Elsevier, 2012)
      Statins reduce the isoprenoids farnesyl and geranylgeranyl pyrophosphate, essential intermediates, which control a diversity of cellular events such as cytoskeleton integrity, adhesion, migration and viability. Cardiac ...
    • Simvastatin induces apoptosis by a Rho-dependent mechanism in cultured cardiac fibroblasts and myofibroblasts 

      Copaja, Miguel; Venegas, Daniel; Aránguiz, Pablo; Canales, Jimena; Vivar, Raúl; Catalán, Mabel; Olmedo, Ivonne; Rodríguez, Andrea E.; Chiong Lay, Mario; Leyton Campos, Lisette; Lavandero González, Sergio; Díaz Araya, Guillermo (2011)
      Several clinical trials have shown the beneficial effects of statins in the prevention of coronary heart disease. Additionally, statins promote apoptosis in vascular smooth muscle cells, in renal tubular epithelial cells ...