Now showing items 1-5 of 5

    • ADAR1 Transcriptome editing promotes breast cancer progression through the regulation of cell cycle and DNA damage response 

      Sagredo, Eduardo A.; Sagredo, Alfredo I.; Blanco, Alejandro; Rojas De Santiago, Pamela; Rivas, Solange; Assar Cuevas, Rodrigo; Pérez, Paola; Marcelain Cubillos, Katherine; Armisen Yáñez, Ricardo (Elsevier, 2020)
      RNA editing has emerged as a novel mechanism in cancer progression. The double stranded RNA-specific adenosine deaminase (ADAR) modifies the expression of an important proportion of genes involved in cell cycle control, ...
    • ADAR1-mediated RNA-editing of 3'UTRs in breast cancer 

      Sagredo, Eduardo A.; Blanco, Alejandro; Sagredo, Alfredo I.; Pérez, Paola; Sepúlveda-Hermosilla, Gonzalo; Morales, Fernanda; Müller, Bettina; Verdugo, Ricardo; Marcelain Cubillos, Katherine; Harismendy, Olivier; Armisén, Ricardo (NLM (Medline), 2018)
      RESULTS: We characterized A to G(I) mRNA editing in 81 breast cell lines, showing increased editing at 3'UTR and exonic regions in breast cancer cells compared to immortalized non-malignant cell lines. In addition, tumors ...
    • TRPM4 channel is involved in regulating epithelial to mesenchymal transition, migration, and invasion of prostate cancer cell lines 

      Sagredo, Alfredo I.; Sagredo, Eduardo A.; Pola, Victor; Echeverría, César; Andaur, Rodrigo; Michea Acevedo, Luis; Stutzin Schottlander, Andrés; Simon, Felipe; Marcelain Cubillos, Katherine; Armisén, Ricardo (Wiley-Liss Inc., 2019)
      © 2018 Wiley Periodicals, Inc. Transient Receptor Potential Melastatin 4 (TRPM4) is a Ca 2+ -activated and voltage-dependent monovalent cation channel, which depolarizes the plasma cell membrane, thereby modulating Ca 2+ ...
    • TRPM4 channel is involved in regulating epithelial to mesenchymal transition, migration, and invasion of prostate cancer cell lines 

      Sagredo, Alfredo I.; Sagredo, Eduardo A.; Pola, Victor; Echeverría, César; Andaur, Rodrigo; Michea Acevedo, Luis; Stutzin Schottlander, Andrés; Simon, Felipe; Marcelain Cubillos, Katherine; Armisén, Ricardo (Wiley-Liss Inc., 2018)
      © 2018 Wiley Periodicals, Inc. Transient Receptor Potential Melastatin 4 (TRPM4) is a Ca2+-activated and voltage-dependent monovalent cation channel, which depolarizes the plasma cell membrane, thereby modulating Ca2+ ...
    • TRPM4 regulates Akt/GSK3-β activity and enhances β-catenin signaling and cell proliferation in prostate cancer cells 

      Sagredo, Alfredo I.; Sagredo, Eduardo A.; Cappelli, Claudio; Báez, Pablo; Andaur, Rodrigo E.; Blanco, Constanza; Tapia, Julio C.; Echeverría, César; Cerda, Oscar; Stutzin Schottlander, Andrés; Simon, Felipe; Marcelain Cubillos, Katherine; Armisén, Ricardo (John Wiley and Sons Ltd., 2018)
      © 2017 The Authors. Published by FEBS Press and John Wiley & Sons Ltd. Increased expression of the TRPM4 channel has been reported to be associated with the progression of prostate cancer. However, the molecular mechanism ...