Now showing items 1-14 of 14

    • Applications of electron spin, resonance and spin trapping in tropical parasitic diseases 

      Olea Azar, Claudio; Rigol Olsen, Carolina; Mendizábal Emaldía, Fernando; Briones, Rodolfo (BENTHAM SCIENCE PUBL LTD, 2006-02)
      Free radicals may be reaction intermediates in biological systems in more situations than are presently recognized. However, progress in detecting such species by Electron Spin Resonance (ESR) has been relatively slow. ESR ...
    • Electrochemical and ESR study of 5-nitrofuryl-containing thiosemicarbazones antiprotozoal drugs 

      Rigol Olsen, Carolina; Olea Azar, Claudio; Mendizábal Emaldía, Fernando; Otero, Lucía; Gambino, Dinorah; González, M.; Cerecetto, Hugo (PERGAMON-ELSEVIER SCIENCE LTD, 2005-10)
      Cyclic voltammetry and electron spin resonance (ESR) techniques were used in the investigation of several potential antiprotozoal thiosemicarbazones nitrofurane derivatives. A self-protonation process involving the ...
    • Electrochemical and microsomal production of free radicals from 1,2,5-oxadiazole N-oxide as potential antiprotozoal drugs 

      Olea Azar, Claudio; Rigol Olsen, Carolina; Mendizábal Emaldía, Fernando; Briones, Rodolfo; Cerecetto, Hugo; Di Maio, R.; Risso, Mariela; González, M.; Porcal, Williams (PERGAMON-ELSEVIER SCIENCE LTD, 2003-01-01)
      The electron spin resonance (ESR) spectra of free radicals obtained by electrolytic or microsomal reduction of several potential antiprotozoal 1,2,5-oxadiazoles were characterized and analyzed. Ab initio molecular orbital ...
    • Electron spin resonance studies in acrylamide polymerization using rhenium complexes as photosensitizers 

      Olea Azar, Claudio; Terraza, C. A.; Guerrero, J.; Rigol Olsen, Carolina; Recabarren Gajardo, Gonzalo Iván (SOCIEDAD CHILENA DE QUIMICA, 2002-09)
      Acrylamide can be polymerized using new catalytic systems. These are based on rhenium complexes as photosensitizers with triethylamine (TEA). Electron Spin Resonance (ESR) was used for the detection of radicals species ...
    • ESR and electrochemical study of 5-nitroindazole derivatives with antiprotozoal activity 

      Olea Azar, Claudio; Cerecetto, Hugo; Gerpe, Alejandra; González, Mercedes; Arán, Vicente J.; Rigol Olsen, Carolina; Opazo, Lucía (PERGAMON-ELSEVIER SCIENCE LTD, 2006-01)
      The electrochemistry of 3-alkoxy- and 3-hydroxy-1-[(omega-(dialkylamino)alkyl]-5-nitroindazole derivatives were characterized using cyclic voltammetry in DMSO. The nitro reduction process was studied and this was affected ...
    • ESR and spin trapping studies of two new potential antitrypanosomal drugs 

      Olea Azar, Claudio; Rigol Olsen, Carolina; Opazo, L.; Morello Casté, Antonio; Maya Arango, Juan; Repetto Scaramelli, Yolanda; Aguirre, G.; Cerecetto, Hugo; Di Maio, R.; González, M.; Porcal, Williams (SOCIEDAD CHILENA DE QUIMICA, 2003-12)
      The Electron Spin Resonance (ESR) spectra of radicals obtained from two new potential antitrypanosomal drugs by Trypanosoma cruzi reduction were analyzed. DMPO Spin Trapping was used to investigate the possible formation ...
    • ESR spin trapping studies of free radicals generated from nitrofuran derivative analogues of nifurtimox by electrochemical and Trypanosoma cruzi reduction 

      Olea Azar, Claudio; Rigol Olsen, Carolina; Mendizábal Emaldía, Fernando; Morello Casté, Antonio; Maya Arango, Juan; Moncada, C.; Cabrera, E.; Di Maio, R.; González, M.; Cerecetto, Hugo (TAYLOR & FRANCIS LTD, 2003-08)
      Electron spin resonance (ESR) spectra of radicals obtained from two analogues of the antiprotozoal drug nifurtimox by electrolytic and Trypanosoma cruzi reduction were analyzed. The electrochemistry of these compounds was ...
    • ESR, electrochemical and reactivity studies of antitrypanosomal palladium thiosemicarbazone complexes 

      Otero, Lucía; Folch, Christian; Barriga, Germán; Rigol Olsen, Carolina; Opazo, Lucía; Vieites, Marisol; Gambino, Dinorah; Cerecetto, Hugo; Norambuena, Ester; Olea Azar, Claudio (Elsevier B.V., 2008-08)
      Cyclic voltammetry (CV) and electron spin resonance (ESR) techniques were used in the investigation of novel palladium complexes with bioactive thiosemicarbazones derived from 5-nitrofurane or 5-nitrofurylacroleine. Sixteen ...
    • In vitro activity and mechanism of action against the protozoan parasite Trypanosoma cruzi of 5-nitrofuryl containing thiosemicarbazones 

      Aguirre, G.; Boiani, Lucía; Cerecetto, Hugo; Fernández, M.; González, M.; Denicola, Ana; Otero, L.; Gambino, Dinorah; Rigol Olsen, Carolina; Olea Azar, Claudio; Faúndez Cáceres, Mario Antonio (PERGAMON-ELSEVIER SCIENCE LTD, 2004-09-15)
      The in vitro growth inhibition activity of new thiosemicarbazone derivatives against the protozoan parasite Trypanosoma cruzi, the causative agent of American trypanosomiasis, are described. The designed compounds combine ...
    • Indazole N-oxide derivatives as antiprotozoal agents: Synthesis, biological evaluation and mechanism of action studies 

      Gerpe, Alejandra; Aguirre, Gabriela; Boiani, Lucía; Cerecetto, Hugo; González, Mercedes; Olea Azar, Claudio; Rigol Olsen, Carolina; Maya Arango, Juan; Morello Casté, Antonio; Piro, Oscar E.; Arán, Vicente J.; Azqueta, Amaia; López de Ceráin, Adela; Monge, Antonio; Rojas, María Antonieta; Yaluff, Gloria (PERGAMON-ELSEVIER SCIENCE LTD, 2006-05-15)
      A series of indazole N-oxide derivatives have been synthesized and their antichagasic and leishmanocidal properties studied. 3-Cyano-2-(4-iodophenyl)-2H-indazole N-1-oxide exhibited interesting antichagasic activity on the ...
    • Nitrofurylsemicarbazone rhenium and ruthenium complexes as anti-trypanosomal agents 

      Otero, Lucía; Aguirre, Gabriela; Boiani, Lucía; Denicola, Ana; Rigol Olsen, Carolina; Olea Azar, Claudio; Maya Arango, Juan; Morello Casté, Antonio; González, Mercedes; Gambino, Dinorah; Cerecetto, Hugo (ELSEVIER, 2006-11)
      Rhenium and ruthenium complexes of the type [(ReOCl2)-O-V(PPh3)L] and [(RuC2)-C-II(DMSO)(2)L], where L are 5-nitroftitylsemicarbazone derivatives, were prepared in an effort to obtain new anti-trypanosomal agents combining ...
    • Novel antitrypanosomal agents based on palladium nitrofurylthiosemicarbazone complexes: DNA and redox metabolism as potential therapeutic targets 

      Otero, Lucía; Vieites, Marisol; Boiani, Lucía; Denicola, Ana; Rigol Olsen, Carolina; Opazo, Lucía; Olea Azar, Claudio; Maya Arango, Juan; Morello Casté, Antonio; Krauth Siegel, R. Luise; Piro, Oscar E.; Castellano, Eduardo; González, Mercedes; Gambino, Dinorah; Cerecetto, Hugo (AMER CHEMICAL SOC, 2006-06-01)
      In the search for new therapeutic tools against American Trypanosomiasis palladium complexes with bioactive nitrofuran-containing thiosemicarbazones as ligands were obtained. Sixteen novel palladium (II) complexes with the ...
    • Novel Benzo[1,2-c]1,2,5-Oxadiazole N-Oxide Derivatives as Antichagasic Agents: Chemical and Biological Studies 

      Olea Azar, Claudio; Rigol Olsen, Carolina; Mendizábal Emaldía, Fernando; Cerecetto, Hugo; Di Maio, R.; González, Mercedes; Porcal, Williams; Morello Casté, Antonio; Repetto Scaramelli, Yolanda; Maya Arango, Juan (BENTHAM SCIENCE PUBL LTD., 2005-06)
      In order to gain inside the mechanism of action of a series of benzo[1,2-c]1,2,5-oxadiazole N-oxide derivatives with in vitro anti-trypanosomal activity, electrochemical and biological studies were performed. Cyclic ...
    • Theoretical study on 5-nitrofuryl thiosemicarbazone radicals electronic properties 

      Rigol Olsen, Carolina; Olea Azar, Claudio; Mendizábal Emaldía, Fernando; Briones, Rodolfo; Cerecetto, Hugo; González, M. (ELSEVIER SCIENCE BV, 2006-09-29)
      Theoretical studies of molecular conformations and electronic properties calculations of eight 5-nitrofuryl thiosemicarbazone free radicals, by means of ab initio (R/UHF), and DFT (R/UB3LYP) methods are presented and ...