Browsing by Author "feac412e-5936-4329-9757-aa9a58848a4d"

Now showing items 1-4 of 4

    • Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease 
      Salazar, Julio; Mena, Natalia P.; Hunot, Stephane; Prigent, Annick; Alvarez Fischer, Daniel; Arredondo, Miguel; Duyckaerts, Charles; Sazdovitch, Veronique; Zhao, Lin; Garrick, Laura M.; Núñez González, Marco; Garrick, Michael D.; Raisman Vozari, Rita; Hirsch, Etienne C. (2008)
      Dopaminergic cell death in the substantia nigra (SN) is central to Parkinson's disease (PD), but the neurodegenerative mechanisms have not been completely elucidated. Iron accumulation in dopaminergic and glial cells in ...
    • Effect of mitochondrial complex I inhibition on Fe-S cluster protein activity 
      Mena, Natalia P.; Bulteau, Anne Laure; Salazar, Julio; Hirsch, Etienne C.; Núñez González, Marco (2011)
      Iron-sulfur (Fe-S) clusters are small inorganic cofactors formed by tetrahedral coordination of iron atoms with sulfur groups. Present in numerous proteins, these clusters are involved in key biological processes such as ...
    • Iron toxicity in neurodegeneration 
      Núñez González, Marco; Urrutia, Pamela J.; Mena, Natalia; Aguirre, Pabla; Tapia, Victoria; Salazar, Julio (2012)
      Iron is an essential element for life on earth, participating in a plethora of cellular processes where one-electron transfer reactions are required. Its essentiality, coupled to its scarcity in aqueous oxidative environments, ...
    • Progressive iron accumulation induces a biphasic change in the glutathione content of neuroblastoma cells 
      Núñez González, Marco; Gallardo, Vivian; Muñoz, Patricia; Tapia, Victoria; Esparza, Andrés; Salazar, Julio; Speisky Cosoy, Hernán (PERGAMON-ELSEVIER SCIENCE LTD, 2004-10-01)
      Glutathione (GSH) constitutes the single most important antioxidant in neurons, whereas iron causes oxidative stress that leads to cell damage and death. Although GSH and iron produce opposite effects on redox cell status, ...