Now showing items 1-6 of 6

    • Annulation of substituted anthracene-9,10-diones yields promising selectively antiproliferative compounds 

      Castro Castillo, Vicente; Suárez Rozas, Cristian; Castro Loiza, Natalia; Theoduloz, Cristina; Cassels Niven, Bruce (Elsevier, 2013)
      Anthraquinone derivatives are well-known antiproliferative compounds, and some are currently used in cancer chemotherapy. Some families of annulated anthraquinone analogs have also been examined for antiproliferative ...
    • Antiproliferative activity and chemical composition of the venom from the Amazonian toad Rhinella marina (Anura: Bufonidae) 

      Schmeda Hirschmann, Guillermo; Quispe, Cristina; Vargas-Arana, Gabriel; Theoduloz, Cristina; Urra Faúndez, Felix; Cárdenas Matus, Julio (Pergamon-Elsevier Science, 2016)
      Little is known on the composition of Peruvian Amazon toad venoms. The large toad Rhinella marina is common in the cleared tropical forests of the Iquitos region and is regarded as poisonous. The venom from two different ...
    • Antiproliferative and proapoptotic activities of aza-annulated naphthoquinone analogs 

      Suárez Rozas, Cristian; Simpson, Sebastián; Fuentes Retamal, Sebastián; Catalán, Mabel; Ferreira, Jorge; Theoduloz, Cristina; Mella, Jaime; Cabezas, David; Cassels Niven, Bruce; Yáñez, Claudia; Castro Castillo, Vicente (Elsevier Ltd, 2019)
      © 2018 1,4-Naphthoquinone derivatives have been widely documented with regard to their biological properties, and particularly their anticancer activities. In the 9,10-anthraquinone family, aza-annulation involving one of ...
    • Efficacy of quercetin against chemically induced murine oral squamous cell carcinoma 

      Droguett, Daniel; Castillo, Christian; Leiva, Elba; Theoduloz, Cristina; Schmeda Hirschmann, Guillermo; Kemmerling Weis, Ulrike (Spandidos Publ, 2015)
      Oral squamous cell carcinoma (OSCC) is the most common form of head and neck cancer, and oxidative damage is associated with the development of OSCCs. Antioxidants have therefore been proposed for use as chemoprotective ...
    • Synthesis of Lakshminine and Antiproliferative Testing of Related Oxoisoaporphines 

      Castro Castillo, Vicente; Rebolledo Fuentes, Marco; Theoduloz, Cristina; Cassels Niven, Bruce (AMER CHEMICAL SOC, 2010-10-20)
      Lakshminine (6-amino-1-aza-5-methoxy-7H-dibenzo[de,h]quinolin-7-one, 1) is a recent addition to the small family of oxoisoaporphine alkaloids and a member of an even smaller set bearing an amino group at C-6. This rare ...
    • Topical Anti-inflammatory Activity of New Hybrid Molecules of Terpenes and Synthetic Drugs 

      Theoduloz, Cristina; Delporte Vergara, Carla; Valenzuela Barra, Gabriela; Silva, Ximena; Cádiz, Solange; Bustamante, Fernanda; Walter Pertino, Mariano; Schmeda Hirschmann, Guillermo (MDPI AG, 2015)
      The aim of the study was to assess changes in the activity of anti-inflammatory terpenes from Chilean medicinal plants after the formation of derivatives incorporating synthetic anti-inflammatory agents. Ten new hybrid ...