Now showing items 1-19 of 19

    • Administration of High Doses of Copper to Capuchin Monkeys Does Not Cause Liver Damage but Induces Transcriptional Activation of Hepatic Proliferative Responses1–3 

      Araya, Magdalena; Núñez, Héctor; Pavez, Leonardo; Arredondo Olguín, Miguel Armando; Méndez, Marco; Cisternas, Felipe; Pizarro Aguirre, Fernando; Sierralta, Walter; Uauy Dagach-Imbarack, Ricardo; González Canales, Mauricio (American Society for Nutrition, 2012)
      Liver cells respond to copper loading upregulating protective mechanisms. However, to date, except for liver content, there are no good indicators that identify individuals with excess liver copper. We hypothesized that ...
    • Antioxidant responses of cortex neurons to iron loading 

      Aguirre, Pabla; Mena, Natalia P.; Tapia, Victoria; Rojas, Alejandro; Arredondo Olguín, Miguel Armando; Núñez González, Marco (2006)
      Brain cells have a highly active oxidative metabolism, yet they contain only low to moderate superoxide dismutase and catalase activities. Thus, their antioxidant defenses rely mainly on cellular reduced glutathione levels. ...
    • Apical distribution of HFE–b2-microglobulin is associated with inhibition of apical iron uptake in intestinal epithelia cells 

      Arredondo Olguín, Miguel Armando; Tapia, Victoria; Rojas, Alejandro; Aguirre, Pabla; Reyes, Francisca; Marzolo Canales, María Paz; Núñez González, Marco (SPRINGER, 2005-10-03)
      Mutations in the HFE gene result in hereditary hemochromatosis, a disorder of iron metabolism characterized by increased intestinal iron absorption. Based on the observation that ectopic expression of HFE strongly inhibits ...
    • Apolipoprotein E polymorphism in type 2 diabetic patients of Talca, Chile 

      Leiva, Elba; Mujica, Verónica; Orrego, Roxana; Prieto, María; Arredondo Olguín, Miguel Armando (ELSEVIER IRELAND, 2005-06)
      Apolipoprotein E (apo E) modulates the metabolism of atherogenic lipoprotein particles and participates in the process of cellular incorporation of specific lipoproteins. Genetic polymorphism of apo E: has beets reported ...
    • CCS and SOD1 mRNA are reduced after copper supplementation in peripheral mononuclear cells of individuals with high serum ceruloplasmin concentration 

      Suazo Romo, Miriam; Olivares, Felipe; Méndez, Marco; Pulgar, Rodrigo; Prohaska, Joseph R.; Arredondo Olguín, Miguel Armando; Pizarro Aguirre, Fernando; Ordóñez Pizarro, Fernando; Araya, Magdalena; González Canales, Mauricio (ELSEVIER SCIENCE INC, 2008-04)
      The limits of copper homeostatic regulation in humans are not known, making it difficult to define the milder effects of early copper excess. Furthermore, a robust assay to facilitate the detection of early stages of ...
    • Chaperones CCS, ATOX and COXIV responses to copper supplementation in healthy adults 

      Araya, Magdalena; Andrews, Mónica; Pizarro Aguirre, Fernando; Arredondo Olguín, Miguel Armando (Springer, 2012-04)
      Assessment of proteins in blood and other tissues has failed to identify markers of early copper effects on health. Studies in animal models show that chaperone of SOD (CCS) respond to changes of copper status. Evidence ...
    • Differential response of interleukin-2 production to chronic copper supplementation in healthy humans 

      Muñoz, Carlos; López, Marcelo; Olivares Grohnert, Manuel; Pizarro Aguirre, Fernando; Arredondo Olguín, Miguel Armando; Araya, Magdalena (EUROPEAN CYTOKINE NETWORK, 2005-12)
      Backgound. Copper (Cu) is an essential trace element for many biological processes including maintenance of both innate and acquired branches of immunity. Objective. To measure the effect of copper supplementation on IL-2 ...
    • Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease 

      Salazar, Julio; Mena, Natalia P.; Hunot, Stephane; Prigent, Annick; Alvarez Fischer, Daniel; Arredondo Olguín, Miguel Armando; Duyckaerts, Charles; Sazdovitch, Veronique; Zhao, Lin; Garrick, Laura M.; Núñez González, Marco; Garrick, Michael D.; Raisman Vozari, Rita; Hirsch, Etienne C. (NATL ACAD SCIENCES, 2008-11-25)
      Dopaminergic cell death in the substantia nigra (SN) is central to Parkinson’s disease (PD), but the neurodegenerative mechanisms have not been completely elucidated. Iron accumulation in dopaminergic and glial cells ...
    • Effects of High Iron and Glucose Concentrations over the Relative Expression of Bcl2, Bax, and Mfn2 in MIN6 Cells 

      Fuentes, Marcela; Andrews, Mónica; Arredondo Olguín, Miguel Armando (Springer Science+Business Media, 2013)
      Type 2 diabetes is characterized by hyperglycemia and oxidative stress. Hyperglycemia is linked to mitochondrial dysfunction and reduced β-cell mass due to the reduced expression of genes such as Mfn2 as well as ...
    • Evaluation of metabolic syndrome in adults of Talca city, Chile 

      Mujica, Verónica; Leiva, Elba; Icaza, Gloria; Díaz, Nora; Arredondo Olguín, Miguel Armando; Moore Carrasco, Rodrigo; Orrego, Roxana; Vásquez, Marcela; Palomo, Iván (BIOMED CENTRAL LTD, 2008-05-15)
      Objective-: Insulin resistance (IR) is an important risk factor for type 2 Diabetes Mellitus (DM2) and cardiovascular disease (CVD). Metabolic Syndrome (MS) is a clustering of metabolic alterations associated to IR; however, ...
    • Glycemic Control and Oxidative Stress Markers and their relationship with the Thioredoxin Interacting Protein (TXNIP) gene in Type 2 Diabetic patients 

      Andrews Guzmán, Mónica; Arredondo Olguín, Miguel Armando; Olivares Gronhert, Manuel (Aula Médica Ediciones, 2015)
      Objective: To investigate the relationship between oxidative stress and biochemical parameters and the expression of TXNIP, IL-6, IL-1 beta and TNF-alpha in peripheral mononuclear cells (PMCs) from type-2 diabetic patients. ...
    • Heme oxygenase 1 overexpression increases iron fluxes in Caco-2 cells 

      Mendiburo, María José; Flores, Sebastián; Pizarro Aguirre, Fernando; Arredondo Olguín, Miguel Armando (2006)
      Heme oxygenase-1 is a microsomal enzyme that, when induced by stress, protects the cells from oxidative injury. Heme oxygenase-1 participates in the cleavage of the heme ring producing biliverdin, CO and ferrous Fe. The ...
    • High Levels of hsCRP are Associated With Carbohydrate Metabolism Disorder 

      Leiva, Elba; Mujica, Verónica; Brito, Katherine; Palomo, Iván; Orrego, Roxana; Moore Carrasco, Rodrigo; Vásquez, Marcela; Guzmán, Luis; Núñez, Sergio; Díaz, Nora; Icaza, Gloria; Arredondo Olguín, Miguel Armando (Wiley Periodicals, 2011)
      Aim: To determine risk parameters associated with high values of high sensitive C-reactive protein (hsCRP) in subjects with different glucose fasting levels. Methods: Anthropometric parameters, arterial pressure, glycemia, ...
    • High Levels of Iron Status and Oxidative Stress in Patients with Metabolic Syndrome 

      Leiva, Elba; Mujica, Verónica; Sepúlveda, Pablo; Guzmán, Luis; Núñez, Sergio; Orrego, Roxana; Palomo, Iván; Andrews, Mónica; Arredondo Olguín, Miguel Armando (Springer, 2013)
      Studies concerning oxidative stress (OxE) parameters have increased, mainly because of its important role in cardiovascular diseases and diabetes complications. The main objective of this study was to evaluate iron ...
    • Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells 

      Urrutia, Pamela J.; Aguirre, Pabla; Esparza, Andrés; Tapia, Victoria; Mena, Natalia P.; Arredondo Olguín, Miguel Armando; González Billault, Christian; Núñez González, Marco (2013)
      Inflammation and iron accumulation are present in a variety of neurodegenerative diseases that include Alzheimer’s disease and Parkinson’s disease. The study of the putative association between inflammation and iron ...
    • Inhibition of iron and copper uptake by iron, copper and zinc 

      Arredondo Olguín, Miguel Armando; Martínez, Ronny; Núñez González, Marco; Ruz, Manuel; Olivares Grohnert, Manuel (2006)
      Interactions of micronutrients can affect absorption and bioavailability of other nutrients by a number of mechanisms. In aqueous solutions, and at higher uptake levels, competition between elements with similar chemical ...
    • Inhibition of iron and copper uptake by iron, copper and zinc 

      Arredondo Olguín, Miguel; Martínez, Ronny; Núñez González, Marco; Ruz, Manuel; Olivares, Manuel (SOCIEDAD BIOLGIA CHILE, 2005-05-05)
      Interactions of micronutrients can affect absorption and bioavailability of other nutrients by a number of mechanisms. In aqueous solutions, and at higher uptake levels, competition between elements with similar chemical ...
    • The mechanisms for regulating absorption of Fe bis-glycine chelate and Fe-ascorbate in Caco-2 cells are similar 

      Mazariegos, Dora Inés; Pizarro Aguirre, Fernando; Ordóñez Pizarro, Fernando; Núñez González, Marco; Arredondo Olguín, Miguel Armando (AMER INST NUTRITION, 2004-02)
      Inorganic iron (Fe) absorption from the diet is controlled mainly in the intestinal tract where apical Fe uptake is inversely related to the Fe content in the enterocyte. Iron bis-glycine chelate is an iron compound that ...
    • Smaller iron particle size improves bioavailability of hydrogen-reduced iron-fortified bread 

      Arredondo Olguín, Miguel Armando; Salvat, Valentina; Pizarro Aguirre, Fernando; Olivares Grohnert, Manuel (PERGAMON-ELSEVIER SCIENCE LTD, 2006-05)
      Bioavailability results, obtained in humans, of wheat flour fortified with elemental iron might not be reliable because these studies have been performed using tracer iron compounds that probably do not have the same ...