Browsing by Author "b013e8b1-76af-4ca3-84dd-a6b957e2ee46"

Now showing items 1-17 of 17

    • Advances in Fetal and Neonatal Physiology 
      Giussani, Dino A.; Niu, Youguo; Herrera Videla, Emilio; Richter, Hans G.; Camm, Emily J.; Thakor, Avnesh S.; Kane, Andrew D.; Hansell, Jeremy A.; Brain, Kirsty L.; Skeffington, Katie L.; Itani, Nozomi; Wooding, F. B. Peter; Cross, Christine M.; Allison, Beth J. (Springer, 2014)
      The quality of the intrauterine environment interacts with our genetic makeup to shape the risk of developing disease in later life. Fetal chronic hypoxia is a common complication of pregnancy. This chapter reviews how ...
    • Chemoreflex and endocrine components of cardiovascular responses to acute hypoxemia in the llama fetus 
      Giussani, Dino A.; Riquelme, Raquel A.; Moraga, Fernando A.; McGarrigle, Hugh H.G.; Gaete, Cristián R.; Sanhueza, Emilia M.; Hanson, Mark A.; Llanos Mansilla, Jorge (1996)
      We tested the hypothesis that the llama fetus has a blunted cardiovascular chemoreflex response to hypoxemia by investigating the effects of acute hypoxemia on perfusion pressure, heart rate, and the distribution of the ...
    • Developmental programming of cardiovascular dysfunction by prenatal hypoxia and oxidative stress 
      Giussani, Dino A.; Camm, Emily J.; Niu, Youguo; Richter, Hans G.; Blanco, Carlos E.; Gottschalk, Rachel; Blake, E. Zachary; Horder, Katy A.; Thakor, Avnesh S.; Hansell, Jeremy A.; Kane, Andrew D.; Wooding, F. B.Peter; Cross, Christine M.; Herrera, Emilio A. (2012)
      Fetal hypoxia is a common complication of pregnancy. It has been shown to programme cardiac and endothelial dysfunction in the offspring in adult life. However, the mechanisms via which this occurs remain elusive, precluding ...
    • Evolving in thin air-Lessons from the llama fetus in the altiplano 
      Llanos Mansilla, Jorge; Riquelme, Raquel A.; Herrera, Emilio A.; Ebensperger Darrouy, Germán; Krause, Bernardo; Reyes, Roberto V.; Sanhueza, Emilia M.; Pulgar, Víctor M.; Behn, Claus; Cabello, Gertrudis; Parer, Julian T.; Giussani, Dino A.; Blanco, Carlos E.; Hanson, Mark A. (2007)
      Compared with lowland species, fetal life for mammalian species whose mothers live in high altitude is demanding. For instance, fetal llamas have to cope with the low fetal arterial PO2 of all species, but also the likely ...
    • Induction of controlled hypoxic pregnancy in large mammalian species 
      Brain, Kirsty L.; Allison, Beth J.; Niu, Youguo; Cross, Christine M.; Itani, Nozomi; Kane, Andrew D.; Herrera, Emilio A.; Giussani, Dino A. (American Physiological Society, 2015)
      © 2015 The Authors. Progress in the study of pregnancy complicated by chronic hypoxia in large mammals has been held back by the inability to measure long-term significant reductions in fetal oxygenation at values similar ...
    • Long-term exposure to high-altitude chronic hypoxia during gestation induces neonatal pulmonary hypertension ... 
      Herrera, Emilio A.; Riquelme, Raquel A.; Ebensperger Darrouy, Germán; Reyes, Roberto V.; Ulloa, César E.; Cabello, Gertrudis; Krause, Bernardo J.; Parer, Julian T.; Giussani, Dino A.; Llanos Mansilla, Jorge (2010)
      We determined whether postnatal pulmonary hypertension induced by 70% of pregnancy at high altitude (HA) persists once the offspring return to sea level and investigated pulmonary vascular mechanisms operating under these ...
    • Maternal chronic hypoxia increases expression of genes regulating lung liquid movement and surfactant ... 
      McGillick, Erin V.; Orgeig, Sandra; Allison, Beth J.; Brain, Kirsty L.; Niu, Youguo; Itani, Nozomi; Skeffington, Katie L.; Kane, Andrew D.; Herrera Videla, Emilio; Giussani, Dino A.; Morrison, Janna L. (Wiley, 2017)
      Chronic fetal hypoxaemia is a common pregnancy complication that may arise from maternal, placental and/or fetal factors. Respiratory outcome of the infant at birth likely depends on the duration, timing and severity of ...
    • Maternal-to-fetal allopurinol transfer and xanthine oxidase suppression in the late gestation pregnant rat 
      Kane, Andrew D.; Camm, Emily J.; Richter, Hans G.; Lusby, Ciara; Tijsseling, Deodata; Kaandorp, Joepe J.; Derks, Jan B.; Ozanne, Susan E.; Giussani, Dino A. (American Physiological Society, 2013)
      © 2013 The Authors. Fetal brain hypoxic injury remains a concern in high-risk delivery. There is significant clinical interest in agents that may diminish neuronal damage during birth asphyxia, such as in allopurinol, an ...
    • Melatonin and vitamin C increase umbilical blood flow via nitric oxide-dependent mechanisms 
      Thakor, Avnesh S.; Herrera, Emilio A.; Serón Ferré, María; Giussani, Dino A. (2010)
      Inadequate umbilical blood flow leads to intrauterine growth restriction, a major killer in perinatal medicine today. Nitric oxide (NO) is important in the maintenance of umbilical blood flow, and antioxidants increase NO ...
    • Reduced cystathionine γ-lyase and increased miR-21 expression are associated with increased vascular ... 
      Cindrova-Davies, Tereza; Herrera, Emilio A.; Niu, Youguo; Kingdom, John; Giussani, Dino A.; Burton, Graham J. (2013)
      Increased vascular impedance in the fetoplacental circulation is associated with fetal hypoxia and growth restriction. We sought to investigate the role of hydrogen sulfide (H2S) in regulating vasomotor tone in the ...
    • Regional brain blood flow and cerebral hemispheric oxygen consumption during acute hypoxaemia in the Ilama fetus 
      Llanos Mansilla, Jorge; Riquelme, Raquel A.; Sanhueza, Emilia M.; Herrera Videla, Emilio; Cabello, Gertrudis; Giussani, Dino A.; Parer, Julian T. (2002)
      Unlike fetal animals of lowland species, the llama fetus does not increase its cerebral blood flow during an episode of acute hypoxaemia. This study tested the hypothesis that the fetal llama brain maintains cerebral ...
    • Role of the α-adrenergic system in femoral vascular reactivity in neonatal llamas and sheep: A comparative ... 
      Moraga, Fernando A.; Reyes, Roberto V.; Herrera, Emilio A.; Riquelme, Raquel A.; Ebensperger Darrouy, Germán; Pulgar, Víctor M.; Parer, Julian T.; Giussani, Dino A.; Llanos Mansilla, Jorge (2011)
      Using an integrative approach at the whole animal, isolated vessels, and molecular levels, we tested the hypothesis that the llama, a species that undergoes pregnancy under the influence of the chronic hypoxia of high ...
    • The heme oxygenase-carbon monoxide system in the regulation of cardiorespiratory function at high altitude 
      Llanos Mansilla, Jorge; Ebensperger Darrouy, Germán; Herrera, Emilio A.; Reyes, Roberto V.; Cabello, Gertrudis; Díaz Díaz, Marcela Cecilia; Giussani, Dino A.; Parer, Julian T. (2012)
      Pulmonary arterial hypertension is one of the most serious pathologies that can affect the 140 million people living at altitudes over 2500. m. The primary emphasis of this review is pulmonary artery hypertension in mammals ...
    • The role of neuropeptide Y in the ovine fetal cardiovascular response to reduced oxygenation 
      Sanhueza, Emilia M.; Johansen-Bibby, Anja A.; Fletcher, A. J W; Riquelme, Raquel A.; Daniels, Alejandro J.; Serón Ferré, María; Gaete, Cristián R.; Carrasco, Jorge E.; Llanos Mansilla, Jorge; Giussani, Dino A. (2003)
      This study investigated the role of neuropeptide Y (NPY) in mediating cardiovascular responses to reduced oxygenation in the late gestation ovine fetus by: (1) comparing the effects on the cardiovascular system of an ...
    • The role of nitric oxide in the cardiopulmonary response to hypoxia in highland and lowland newborn llamas 
      Reyes, Roberto V.; Díaz Díaz, Marcela Cecilia; Ebensperger Darrouy, Germán; Herrera, Emilio A.; Quezada, Sebastián A.; Hernández, Ismael; Sanhueza, Emilia M.; Parer, Julian T.; Giussani, Dino A.; Llanos Mansilla, Jorge (Blackwell Publishing Ltd, 2018)
      © 2018 The Physiological Society. Key points: Perinatal hypoxia causes pulmonary hypertension in neonates, including humans. However, in species adapted to hypoxia, such as the llama, there is protection against pulmonary ...
    • Weak cardiovascular defence to hypotensive stress in the chronically hypoxic fetus 
      Allison, Beth J.; Brain, Kirsty L.; Niu, Youguo; Kane, Andrew D.; Herrera Videla, Emilio; Botting, Kimberley J.; Cross, Christine M.; Itani, Nozomi; Skeffington, Katie L.; Giussani, Dino A. (Sage Pubications INC, 2018)
    • Xanthine oxidase and the fetal cardiovascular defence to hypoxia in late gestation ovine pregnancy 
      Kane, Andrew D.; Hansell, Jeremy A.; Herrera, Emilio A.; Allison, Beth J.; Niu, Youguo; Brain, Kirsty L.; Kaandorp, Joepe J.; Derks, Jan B.; Giussani, Dino A. (2014)
      Hypoxia is a common challenge to the fetus, promoting a physiological defence to redistribute blood flow towards the brain and away from peripheral circulations. During acute hypoxia, reactive oxygen species (ROS) interact ...