Now showing items 21-24 of 24

    • Rapamycin requires AMPK activity and p27 expression for promoting autophagy-dependent Tsc2-null cell survival 

      Campos, Tania; Ziehe, Javiera; Fuentes Villalobos, Francisco; Riquelme, Orlando; Peña, Daniela; Troncoso Cotal, Rodrigo; Lavandero González, Sergio; Morín, Violeta; Pincheira, Roxana; Castro, Ariel F. (Elsevier, 2016)
      Tuberous sclerosis complex (TSC) disease results from inactivation of the TSC1 or TSC2 gene, and is characterized by benign tumors in several organs. Because TSC tumorigenesis correlates with hyperactivation of mTORC1, ...
    • Regulation of cardiomyocyte autophagy by calcium 

      Shaikh, Soni; Troncoso Cotal, Rodrigo; Criollo Céspedes, Alfredo; Bravo Sagua, Roberto; García Nannig, Lorena; Morselli, Eugenia; Cifuentes, Mariana; Quest, Andrew F. G.; Hill, Joseph A.; Lavandero González, Sergio (Amer Physiological Soc, 2016)
      Calcium signaling plays a crucial role in a multitude of events within the cardiomyocyte, including cell cycle control, growth, apoptosis, and autophagy. With respect to calcium-dependent regulation of autophagy, ion ...
    • The STIM1 inhibitor ML9 disrupts basal autophagy in cardiomyocytes by decreasing lysosome content 

      Shaikh, S.; Troncoso Cotal, Rodrigo; Mondaca Ruff, David; Parra Ortíz, María Valentina; García Nannig, Lorena; Chiong Lay, Mario; Lavandero González, Sergio (Elsevier, 2018)
      Stromal-interaction molecule 1 (STIM1)-mediated store-operated Ca2+ entry (SOCE) plays a key role in mediating cardiomyocyte hypertrophy, both in vitro and in vivo. Moreover, there is growing support for the contribution ...
    • Unsaturated fatty acids induce non-canonical autophagy 

      Niso Santano, Mireia; Malik, Shoaib; Pietrocola, Federico; Bravo San Pedro, José; Mariño, Guillermo; Cianfanelli, Valentina; Ben-Younès, Amena; Troncoso Cotal, Rodrigo; Markaki, Maria; Sica, Valentina; Izzo, Valentina; Chaba, Kariman; Bauvy, Chantal; Dupont, Nicolas; Kepp, Oliver; Rockenfeller, Patrick; Wolinski, Heimo; Madeo, Frank; Lavandero González, Sergio; Codogno, Patrice; Harper, Francis; Pierron, Gérard; Tavernarakis, Nektarios; Cecconi, Francesco; Maiuri, Maria Chiara; Galluzzi, Lorenzo; Kroemer, Guido (Wiley-Blackwell, 2015)
      To obtain mechanistic insights into the cross talk between lipolysis and autophagy, two key metabolic responses to starvation, we screened the autophagy-inducing potential of a panel of fatty acids in human cancer cells. ...