Browsing by Author "201-0010593"
Now showing items 21-40 of 57
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Israel Jacard, Yedy; Rivera Meza, Mario; Karahanian, Eduardo; Quintanilla González, María Elena; Tampier de Jong, Lutske; Morales Retamales, Paola; Herrera-Marschitz Muller, Mario (FRONTIERS RESEARCH FOUNDATION, 2013-07-08)Ethanol is metabolized into acetaldehyde mainly by the action of alcohol dehydrogenase in the liver, while mainly by the action of catalase in the brain. Aldehyde dehydrogenase-2 metabolizes acetaldehyde into acetate in ...
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Ocaranza, Paula; Quintanilla González, María Elena; Tampier de Jong, Lutske; Karahanian, Eduardo; Sapag, Amalia; Israel Jacard, Yedy (2008)Background: Some gene polymorphisms strongly protect against the development of alcoholism. A large proportion of East Asians carry a protective inactivating mutation in aldehyde dehydrogenase (ALDH2*2). These subjects ...
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Genetic and environmental influences on ethanol consumption: Perspectives from preclinical research Pautassi, Ricardo M.; Camarini, Rosana; Quadros, Isabel Marian; Miczek, Klaus A.; Israel Jacard, Yedy (Blackwell Publishing Ltd, 2010)Background: Alcohol use disorders (abuse and dependence, AUD) are multifactorial phenomena, depending on the interplay of environmental and genetic variables. Method: This review describes current developments in animal ...
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O'Dowd, Brian F.; Rothhammer Engel, Francisco; Israel Jacard, Yedy (1990)Using the polymerase chain reaction to amplify genomic DNA from hair roots, we have examined the mitochondrial aldehyde dehydrogenase (ALDH2) genotypes of 28 individuals from the South American Mapuche Indians. We have ...
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Ezquer, Fernando; Núñez González, Marco; Rojas, Alejandro; Asenjo de Leuze, Juan; Israel Jacard, Yedy (SOCIEDAD BIOLGIA CHILE, 2006)Levels of body iron should be tightly controlled to prevent the formation of oxygen radicals. lipoperoxidation. genotoxicity, and the production of cytotoxic cytokines, which result in damage to a number of organs. Enterocytes ...
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Fernández Arancibia, Virginia; Videla Cabrera, Luis; Tapia Opazo, Gladys; Israel Jacard, Yedy (2002)Thyroid hormone-induced calorigenesis contributes to liver oxidative stress and promotes an increased respiratory burst activity in Kupffer cells, which could conceivably increase the expression of redox-sensitive genes, ...
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Cortínez Flores, Gabriel Alejandro (Universidad de ChilePrograma Cybertesis, 2008)El alcoholismo es una enfermedad multifactorial que genera una serie de trastornos personales, sociales y de salud pública. Según estimaciones del Ministerio de Salud de Chile el abuso en el consumo de alcohol y el alcoholismo ...
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Ponnappa, Biddanda C.; Israel Jacard, Yedy; Aini, María; Zhou, Feng; Russ, Rachel; Cao, Qing-na; Yiyang, Hu; Rubin, Raphael (PERGAMON-ELSEVIER SCIENCE LTD, 2005-02-15)Elevated serum tumor necrosis factor alpha JNF-alpha) levels predict mortality in patients with alcoholic liver disease. Administration of anti-TNF-alpha antibodies, obliteration of Kupffer cells or gut sterilization protect ...
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Quintanilla González, María Elena; Ezquer, Fernando; Morales Retamales, Paola; Ezquer, Marcelo; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy (Wiley, 2020)
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Encina, Gonzalo; Ezquer, Fernando; Conget, Paulette; Israel Jacard, Yedy (2011)Transgenic mice carrying the human insulin gene driven by the K-cell glucose-dependent insulinotropic peptide (GIP) promoter secrete insulin and display normal glucose tolerance tests after their pancreatic β-cells have ...
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Israel Jacard, Yedy; Ezquer, Fernando; Quintanilla González, María Elena; Morales, Paola; Ezquer, Marcelo; Herrera-Marschitz Muller, Mario (2017)© The Author 2016. Medical Council on Alcohol and Oxford University Press. All rights reserved. Study describes the blockade of relapse-like alcohol drinking by mesenchymal stem cells (MSCs). High alcohol-intake bred rats ...
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Farfán, Nancy; Carril, Jaime; Redel, Martina; Zamorano, Marta; Araya, Maureen; Monzón, Estephania; Alvarado, Raúl; Contreras, Norton; Tapia Bustos, Andrea; Quintanilla González, María; Ezquer, Fernando; Valdés, José Luis; Israel Jacard, Yedy; Herrera Marschitz, Mario; Morales Retamales, Eugenia (2020)Perinatal Asphyxia (PA) is a leading cause of motor and neuropsychiatric disability associated with sustained oxidative stress, neuroinflammation, and cell death, affecting brain development. Based on a rat model of global ...
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Ezquer, Fernando; Quintanilla González, María Elena; Morales, Paola; Santapau, Daniela; Ezquer, Marcelo; Kogan Bocian, Marcelo; Salas Huenuleo, Edison; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy (Blackwell Publishing Ltd, 2018)© 2018 Society for the Study of AddictionChronic ethanol consumption leads to brain oxidative stress and neuroinflammation, conditions known to potentiate and perpetuate each other. Several studies have shown that ...
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Rivera Meza, Mario; Quintanilla González, María Elena; Tampier de Jong, Lutske; Mura, Casilda V.; Sapag, Amalia; Israel Jacard, Yedy (2010)Humans who carry a point mutation in the gene coding for alcohol dehydrogenase-1B (ADH1B*2; Arg47His) are markedly protected against alcoholism. Although this mutation results in a 100-fold increase in enzyme activity, it ...
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Juricic Urzúa, María de los Angeles (Universidad de ChileCyberDocs, 2010)Las propiedades reforzantes del etanol en el sistema nervioso central (SNC), que se postula son responsables de la auto-administración repetida de alcohol, se deben al aumento de la liberación de dopamina, inducido por ...
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Sapag, Amalia; Tampier de Jong, Lutske; Prieto, A.; Quintanilla González, María Elena; Moncada, C.; Israel Jacard, Yedy (LIPPINCOTT WILLIAMS & WILKINS, 2003-08)Genetic factors influence alcohol consumption and alcoholism. A number of groups have bred alcohol drinker and non drinker rat strains, but genetic determinants remain unknown. The University of Chile rat lines UChA (low ...
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Quintanilla González, María Elena; Ezquer, Fernando; Morales Retamales, Paola; Ezquer, Marcelo; Olivares, Belén; Santapau, Daniela; Herrera-Marschitz Muller, Mario; Israel Jacard, Yedy (Frontiers Media, 2020)Chronic ethanol intake results in brain oxidative stress and neuroinflammation, which have been postulated to perpetuate alcohol intake and to induce alcohol relapse. The present study assessed the mechanisms involved in ...
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Berrios Cárcamo, Pablo; Quezada, Mauricio; Quintanilla González, María Elena; Morales, Paola; Ezquer, Marcelo; Herrera Marschitz, Mario; Israel Jacard, Yedy; Ezquer, Fernando (MDPI, 2020)Drug abuse is a major global health and economic problem. However, there are no pharmacological treatments to effectively reduce the compulsive use of most drugs of abuse. Despite exerting different mechanisms of action, ...
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Wolnitzky Wenk, Javier Humberto (Universidad de ChilePrograma Cybertesis, 2008)El riesgo individual de alcoholismo tiene un componente hereditario de 40 a 60%. Los únicos factores genéticos bien establecidos para una susceptibilidad diferenciada al alcoholismo son polimorfismos en los genes de las ...
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Sapag, Amalia; González Martínez, Ginez Andrés; Lobos González, Lorena; Encina, Gonzalo; Tampier de Jong, Lutske; Israel Jacard, Yedy; Quintanilla González, María Elena (2009)OBJECTIVE: Alcohol is detoxified in the liver by oxidizing enzymes that require nicotinamide adenine dinucleotide (NAD) such that, in the rat, the availability of NAD contributes to control voluntary ethanol intake. The ...