Now showing items 21-35 of 35

    • Hyperosmotic stress-dependent NFκB activation is regulated by reactive oxygen species and IGF-1 in cultured cardiomyocytes 

      Eisner, Verónica; Criollo Céspedes, Alfredo; Quiroga, Clara; Olea Azar, Claudio; Santibañez, Juan Francisco; Troncoso, Rodrigo; Chiong Lay, Mario; Díaz Araya, Guillermo; Foncea, Rocío; Lavandero González, Sergio (2006)
      We have recently shown that hyperosmotic stress activates p65/RelB NFκB in cultured cardiomyocytes with dichotomic actions on caspase activation and cell death. It remains unexplored how NFκB is regulated in cultured rat ...
    • Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress 

      Bravo Méndez, Roberto; Vicencio Bustamante, José Miguel; Parra Ortíz, María Valentina; Troncoso, Rodrigo; Muñoz, Juan Pablo; Bui, Michael; Quiroga Lagos, Clara; Rodríguez Villarroel, Andrea Elizabeth; Verdejo, Hugo E.; Ferreira Parker, Jorge; Iglewski, Miriam; Chiong Lay, Mario; Simmen, Thomas; Zorzano, Antonio; Hill, Joseph A.; Rothermel, B. A.; Szabadkai, Gyorgy; Lavandero González, Sergio (COMPANY OF BIOLOGISTS LTD., 2011-07-15)
      Increasing evidence indicates that endoplasmic reticulum (ER) stress activates the adaptive unfolded protein response (UPR), but that beyond a certain degree of ER damage, this response triggers apoptotic pathways. The ...
    • Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the AktmTOR-NFkB-Opa-1 signaling pathway 

      Parra, Valentina; Verdejo, Hugo E.; Iglewski, Myriam; Del Campo, Andrea; Troncoso, Rodrigo; Jones, Deborah; Zhu, Yi; Kuzmicic Previtali, Jovan Paolo; Pennanen, Christian; López Crisosto, Camila; Jaña, Fabián; Ferreira, Jorge; Noguera, Eduard; Chiong Lay, Mario; Bernlohr, David A.; Klip, Amira (2014)
      Insulin regulates heart metabolism through the regulation of insulin-stimulated glucose uptake. Studies have indicated that insulin can also regulate mitochondrial function. Relevant to this idea, mitochondrial function ...
    • Interacción entre los polimorfismos del receptor ß1 y ß2 adrenérgico como predictor de riesgo de insuficiencia cardiaca crónica 

      Moraga, Francisco; Troncoso, Rodrigo; Mellado, Rose Marie; Díaz Araya, Guillermo; Vukasovic Ramírez, José Luis; Greig, Douglas; Pérez, Osvaldo; García Nannig, Lorena; Roldán, Juan; Ocaranza, María Paz; Jalil Milad, Jorge; Chiong Lay, Mario; Castro, Pablo (SOC MEDICA SANTIAGO, 2008-11)
      Background: beta adrenergic receptors (AR) are highly polymorphic and important regulators of cardiovascular homeostatis. Among these, beta(1) and beta(2) AR regulate cardiac contractility and frequency and are important ...
    • Interactions between ß 1 and ß 2 adrenergic receptor polymorphisms as risk factors for chronic heart failure Interacción entre los polimorfismos del receptor ß 1 y ß 2 adrenérgico como predictor de riesgo de insuficiencia cardiaca crónica 

      Moraga, Francisco; Troncoso, Rodrigo; Mellado, Rosemarie; Díaz Araya, Guillermo; Vukasovic, José Luis; Greig, Douglas; Pérez, Osvaldo; García, Lorena; Roldán, Juan; Ocaranza, María Paz; Jalil, Jorge; Chiong Lay, Mario; Castro, Pablo (2008)
      Background: ß adrenergic receptors (AR) are highly polymorphic and important regulators of cardiovascular homeostasis. Among these, ß1 and ß2 AR regulate cardiac contractility and frequency and are important pharmacological ...
    • Irisin is weakly associated with usual physical activity in young overweight women La irisina se asocia débilmente con la actividad física habitual en mujeres jóvenes con sobrepeso 

      Tenorio, Beatriz; Jiménez, Teresa; Barrera, Gladys; Hirsch Birn, Sandra; Maza Cave, María Pía de la; Troncoso, Rodrigo; Farias, María Belén; Rodríguez, Juan Manuel; Bunout Barnett, Daniel (Grupo Aula Medica S.A., 2017)
      © 2017, Grupo Aula Medica S.A. All rights reserved.Purpose: To determine if irisin plasma levels are associated with regular physical activity, body composition and metabolic parameters in women subjected to calorie ...
    • Matrix metalloproteinase-9 activity is associated to oxidative stress in patients with acute coronary syndrome 

      Bittner, Alex; Alcaíno Gálvez, Hernán Alejandro; Castro, Pablo F.; Pérez, Osvaldo; Corbalán, Ramón; Troncoso, Rodrigo; Chiong Lay, Mario; Mellado, Rosemarie; Moraga, Francisco; Zanolli, Diego; Winter, José L.; Zamorano, Juan J.; Díaz Araya, Guillermo; Lavandero González, Sergio (2010)
    • Metabolic syndrome and antipsychotics: The role of mitochondrial fission/fusion imbalance 

      Campo, Andrea del; Bustos, Catalina; Mascayano, Carolina; Acuña Castillo, Claudio; Troncoso, Rodrigo; Rojo, Leonel E. (Frontiers Media SA, 2018)
      Second-generation antipsychotics (SGAs) are known to increase cardiovascular risk through several physiological mechanisms, including insulin resistance, hepatic steatosis, hyperphagia, and accelerated weight gain. There ...
    • Metabolismo energético del corazón y sus proyecciones en el tratamiento de la insuficiencia cardíaca 

      Castro, Pablo; Gabrielli, Luigi A.; Verdejo, Hugo; Greig, Douglas; Mellado, Rose Marie; Concepción, Roberto; Sepúlveda Morales, Luis; Vukasovic Ramírez, José Luis; García Nannig, Lorena; Pizarro, Marcela; Pivet, Deisy; Carrillo, Constanza; Tapia, Fabiola; Navarro, Mario; Troncoso, Rodrigo; Baraona, Fernando; Llevaneras, Silvana; Hernández, Claudia; Godoy, Iván; Jalil Milad, Jorge; Quintana, Juan Carlos; Orellana, Pilar; Chiong Lay, Mario; Lavandero González, Sergio (SOC MEDICA SANTIAGO, 2010-08)
      It is unknown why heart failure progresses even when patients are treated with the best therapy available. Evidences suggest that heart failure progression is due to loss of neurohumoral blockade in advanced stages of the ...
    • Mitochondria, myocardial remodeling, and cardiovascular disease 

      Verdejo, Hugo; Campo, Andrea del; Troncoso, Rodrigo; Gutiérrez, Tomás; Toro, Barbra; Quiroga, Clara; Pedrozo Cibils, Zully; Muñoz, Juan; García, Lorena; Castro, Pablo; Lavandero González, Sergio (2012)
      The process of muscle remodeling lies at the core of most cardiovascular diseases. Cardiac adaptation to pressure or volume overload is associated with a complex molecular change in cardiomyocytes which leads to anatomic ...
    • Mitochondrial fragmentation impairs insulin-dependent glucose uptake by modulating Akt activity through mitochondrial Ca2+ uptake 

      Del Campo, Andrea; Parra, Valentina; Vásquez Trincado, César Alonso; Gutiérrez, Tomás; Morales, Pablo E.; López Crisosto, Camila; Bravo Sagua, Roberto; Navarro Márquez, Mario F.; Verdejo, Hugo E.; Contreras Ferrat, Ariel Eduardo; Troncoso, Rodrigo; Chiong Lay, Mario; Lavandero González, Sergio (2014)
      Insulin is a major regulator of glucose metabolism, stimulating its mitochondrial oxidation in skeletal muscle cells. Mitochondria are dynamic organelles that can undergo structural remodeling in order to cope with these ...
    • Organelle communication: Signaling crossroads between homeostasis and disease 

      Bravo Sagua, Roberto; Torrealba, Natalia; Paredes, Felipe; Morales, Pablo E.; Pennanen Saavedra, Christian; López Crisosto, Camila; Troncoso, Rodrigo; Criollo Céspedes, Alfredo; Chiong Lay, Mario; Hill, Joseph A.; Simmen, Thomas; Quest, Andrew F. G.; Lavandero González, Sergio (Elsevier, 2014)
      Cellular organelles do not function as isolated or static units, but rather form dynamic contacts between one another that can be modulated according to cellular needs. The physical interfaces between organelles are ...
    • Regulation of autophagy by Insulin/IGF-1 signaling pathways 

      Troncoso, Rodrigo; Vásquez Trincado, César; Campo, Andrea del; Gatica, Damián; Morales, Pablo; Paredes, Felipe; Gutiérrez, Tomás; López Crisosto, Camila; Lavandero González, Sergio; Torrealba, Natalia; García Nannig, Lorena; Díaz Araya, Guillermo; Battiprolu, Pavan K.; Nemchenko, Andriy; Ferdous, Anwarul; Gillette, Thomas G.; Hill, Joseph A. (Nova Science Publishers, 2012)
    • Regulation of Cardiac Autophagy by Insulin-like Growth Factor 1 

      Troncoso, Rodrigo; Díaz Elizondo, Jessica; Espinoza, Sandra P.; Navarro Márquez, Mario F.; Oyarzún, Alejandra P.; Riquelme, Jaime A.; García Carvajal, Ivonne; Díaz Araya, Guillermo; García Nannig, Lorena; Hill, Joseph A.; Lavandero González, Sergio (2013-07)
      Insulin-like growth factor-1 (IGF-1) signaling is a key pathway in the control of cell growth and survival. Three critical nodes in the IGF-1 signaling pathway have been described in cardiomyocytes: protein kinase ...
    • Trypanosoma cruzi calreticulin: A possible role in Chagas' disease autoimmunity 

      Ribeiro, Carolina Hager; López, Nandy C.; Ramírez, Galia A.; Valck, Carolina E.; Molina, María Carmen; Aguilar, Lorena; Rodríguez, Margarita; Maldonado, Ismael; Martínez, Ramón; González, Carlos; Troncoso, Rodrigo; Lavandero González, Sergio; Gingras, Alexandre R.; Schwaeble, Wilhelm (2009)
      Trypanosoma cruzi (T. cruzi) is the causative agent of Chagas' disease, an endemic and chronic illness that affects 18 million people in Latin America. The mechanisms underlying its pathogenesis are controversial. There ...