Browsing by Author "f3726e28-e8ba-494d-bf27-4a035ef56333"

Now showing items 21-35 of 35

    • Insulin/NFκB protects against ischemia-induced necrotic cardiomyocyte death 
      Díaz, Ariel; Humeres, Claudio; González, Verónica; Gómez, María Teresa; Montt, Natalia; Sánchez, Gina; Chiong Lay, Mario; García Nannig, Lorena (Academic Press Inc., 2015)
      In the heart, insulin controls key functions such as metabolism, muscle contraction and cell death. However, all studies have been focused on insulin action during reperfusion. Here we explore the cardioprotective action ...
    • Levels of plasma angiotensin-(1-7) in patients with hypertension who have the angiotensin-1-converting ... 
      Jalil Milad, Jorge; Palomera Gómez, Cristián Alejandro; Ocaranza, María Paz; Godoy, Iván; Román, Maritza; Chiong Lay, Mario; Lavandero González, Sergio (EXCERPTA MEDICA INC, 2003-09-15)
      In patients with hypertension who have the DD-ACE genotype (higher angiotensin-converting enzyme [ACE] activity), plasma levels of angiotensin-(1-7) are 4 times lower than in patients with the II-ACE genotype (lower ACE ...
    • Light-induced release of the cardioprotective peptide angiotensin-(1-9) from thermosensitive liposomes with ... 
      Bejarano, Julián; Rojas, Aldo; Ramírez Sagredo, Andrea; Riveros Salvatierra, Ana; Morales Zavala, Francisco; Flores, Yvo; Riquelme Meléndez, Jaime; Guzmán, Fanny; Araya, Eyleen; Chiong Lay, Mario; Ocaranza, María Paz; Morales Montecinos, Javier; Villamizar Sarmiento, María Gabriela; Sánchez Vergara, Gina; Lavandero González, Sergio; Kogan, Marcelo J. (Elsevier, 2020)
      Angiotensin-(1-9), a component of the non-canonical renin-angiotensin system, has a short half-life in blood. This peptide has shown to prevent and/or attenuate hypertension and cardiovascular remodeling. A controlled ...
    • Mechanical stretch increases L-type calcium channel stability in cardiomyocytes through a polycystin-1/AK ... 
      Córdova, Andrés; Olmedo, Ivonne; Riquelme, J.; Barrientos, G.; Sánchez, G.; Gillette, Thomas G.; Lavandero González, Sergio; Chiong Lay, Mario; Donoso, P.; Pedrozo Cibils, Zully (Elsevier Science BV, 2018)
      The L-type calcium channel (LTCC) is an important determinant of cardiac contractility. Therefore, changes in LTCC activity or protein levels could be expected to affect cardiac function. Several studies describing LTCC ...
    • Moderate Aerobic Exercise Training Prevents the Augmented Hepatic Glucocorticoid Response Induced by High-Fat ... 
      Dassonvalle, Jonatan; Díaz Castro, Francisco; Donoso Barraza, Camila; Sepúlveda, Carlos; Pino de la Fuente, Francisco; Pino, Pamela; Espinosa Escalona, Berta; Chiong Lay, Mario; Llanos Silva, Miguel; Troncoso Cotal, Rodrigo (MDPI, 2020)
      Glucocorticoids (GCs) are critical regulators of energy balance. Their deregulation is associated with the development of obesity and metabolic syndrome. However, it is not understood if obesity alters the tissue glucocorticoid ...
    • Modulatory Effect of 2-(4-Hydroxyphenyl)amino-1,4-naphthoquinone on Endothelial Vasodilation in Rat Aorta 
      Palacios, Javier; Cifuentes, Fredi; Valderrama, Jaime A.; Benites, Julio; Ríos, David; González, Constanza; Chiong Lay, Mario; Cartes Saavedra, Benjamín; Lafourcade, Carlos; Wyneken, Úrsula (2016)
      The vascular endotheliumplays an essential role in the control of the blood flow. Pharmacological agents like quinone (menadione) at various doses modulate this process in a variety of ways. In this study, Q7, a ...
    • Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with alpha v ... 
      Ávalos, Ana María; Valdivia, A. D.; Muñoz, Nicolás; Herrera Molina, Rodrigo; Tapia Pineda, Julio; Lavandero González, Sergio; Chiong Lay, Mario; Burridge, Keith; Schneider, P.; Quest, Andrew F. G.; Leyton Campos, Lisette (COMPANY OF BIOLOGISTS LTD, 2009-10)
      Clustering of alpha v beta 3 integrin after interaction with the RGD-like integrin-binding sequence present in neuronal Thy-1 triggers formation of focal adhesions and stress fibers in astrocytes via RhoA activation. A ...
    • Octadecyl silica: A solid phase for protein purification by immunoadsorption 
      Chiong Lay, Mario; Lavandero González, Sergio; Ramos, Rodrigo; Aguillón Gutiérrez, Juan Carlos; Ferreira, Arturo (1991)
      Immunoaffinity chromatography involves binding of an antigen or antibody to a solid matrix, usually agarose, frequently using the cyanogen bromide method. These methods are laborious, rather expensive, and their use has ...
    • Pro-fibrotic effect of oxidized LDL in cardiac myofibroblasts 
      Villa, Mónica; Cerda Opazo, Paulina; Jiménez Gallegos, Danica; Garrido Moreno, Valeria; Chiong Lay, Mario; Quest, Andrew F. G.; Toledo, Jorge; García Nannig, Lorena (Elsevier, 2020)
      Inflammatory signals associated with cardiac diseases trigger trans-differentiation of cardiac fibroblasts to cardiac myofibroblasts. Cardiac myofibroblasts are the main cell type involved in the development of cardiac ...
    • Role of interleukin-6 in vascular health and disease 
      Villar Fincheira, Paulina; Sanhueza Olivares, Fernanda; Norambuena Soto, Ignacio; Cancino Arenas, Nicole; Hernández Vargas, Felipe; Troncoso Cotal, Rodrigo; Gabrielli, Luigi; Chiong Lay, Mario (Frontiers Media, 2021)
      IL-6 is usually described as a pleiotropic cytokine produced in response to tissue injury or infection. As a pro-inflammatory cytokine, IL-6 activates innate and adaptative immune responses. IL-6 is released in the innate ...
    • Sarcoplasmic reticulum and calcium signaling in muscle cells: Homeostasis and disease 
      Bravo Sagua, Roberto; Parra Ortiz, Valentina; Muñoz Córdova, Felipe; Sánchez Aguilera, Pablo; Garrido, Valeria; Contreras Ferrat, Ariel; Chiong Lay, Mario; Lavandero González, Sergio (Elsevier, 2020)
      The sarco/endoplasmic reticulum is an extensive, dynamic and heterogeneous membranous network that fulfills multiple homeostatic functions. Among them, it compartmentalizes, stores and releases calcium within the intracellular ...
    • The STIM1 inhibitor ML9 disrupts basal autophagy in cardiomyocytes by decreasing lysosome content 
      Shaikh, S.; Troncoso Cotal, Rodrigo; Mondaca Ruff, David; Parra Ortíz, María Valentina; García Nannig, Lorena; Chiong Lay, Mario; Lavandero González, Sergio (Elsevier, 2018)
      Stromal-interaction molecule 1 (STIM1)-mediated store-operated Ca2+ entry (SOCE) plays a key role in mediating cardiomyocyte hypertrophy, both in vitro and in vivo. Moreover, there is growing support for the contribution ...
    • TonEBP suppresses IL-10-mediated immunomodulation 
      Choi, Soo Youn; Hee Lee, Hwan; Lee, Jun Ho; Ye, Byeong Jin; Yoo, Eun Jin; Kang, Hyun Je; Jung, Gyu Won; An, Seung Min; Lee-Kwon, Whaseon; Chiong Lay, Mario; Lavandero González, Sergio; Kwon, Hyug Moo (Nature, 2016)
      TonEBP is a key transcriptional activator of M1 phenotype in macrophage, and its high expression is associated with many inflammatory diseases. During the progression of the inflammatory responses, the M1 to M2 phenotypic ...
    • Transforming growth factor-beta and Forkhead box O transcription factors as cardiac fibroblast regulators 
      Norambuena Soto, Ignacio; Núñez Soto, Constanza; Sanhueza Olivares, Fernanda; Cancino Arenas, Nicole; Mondaca Ruff, David; Vivar Sánchez, Raúl; Díaz Araya, Guillermo; Mellado, Rosemarie; Chiong Lay, Mario (IRCA-BSSA, 2017)
      Fibroblasts play several homeostatic roles, including electrical coupling, paracrine signaling and tissue repair after injury. Fibroblasts have low secretory activity. However, in response to injury, they differentiate to ...
    • Vasodilator and hypotensive effects of pure compounds and hydroalcoholic extract of Xenophyllum poposum ... 
      Cifuentes, Fredi; Palacios, Javier; Kuzmicic, Jovan; Carvajal, Lorena; Muñoz, Fernanda; Quispe, Cristina; Nwokocha, Chukwuemeka R.; Morales, Glauco; Norambuena Soto, Ignacio; Chiong Lay, Mario; Paredes, Adrián (Elsevier GmbH, 2018)
      © 2018 Background: Xenophyllum poposum is an endemic species of the Andes Cordillera, popularly known as Popusa. Popusa is widely used by mountain communities as a folk medicine to treat altitude sickness and hypertension. ...